The agreement of left ventricular function parameters between 99mTc-tetrofosmin gated myocardial SPECT and gated myocardial MRI

Kuroiwa, Yasuyoshi; Nagamachi, Shigeki; Miyati, Tosiaki; Yamaguchi, Kenichiro; Nishii, Ryuichi; Kuga, Noriyuki; Azuma, Toshiya; Arita, Hideo; Maeda, Masaji; Tamura, Shozo; Kawai, Keiichi

doi:10.1007/s12149-011-0546-3

Cited by 8 publications

(4 citation statements)

References 45 publications

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“…In contrast, a substantial bias was found in the measurement of ventricular volumes. This result is consistent with previous studies that compared QGS analysis with cardiac MR, reporting an underestimation of ventricular volumes even with 16-frame gating (29,34,35). Our results showed that this underestimation persists with CZT SPECT cameras, despite a higher spatial resolution.…”

Section: Discussionsupporting

confidence: 93%

Absolute Quantification of Left Ventricular Global and Regional Function at Nuclear MPI Using Ultrafast CZT SPECT: Initial Validation Versus Cardiac MR

et al. 2013

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We sought to evaluate the accuracy of myocardial perfusion imaging (MPI) using cadmium-zinc-telluride (CZT) SPECT cameras for the measurement of left ventricular (LV) global and regional function, and the performance of absolute wall motion (WM) and wall thickness (WT) measurements for the detection of myocardial scarring, using cardiac MR as a reference. Methods: Sixty patients with known or suspected coronary artery disease underwent MPI using a CZT SPECT camera, as well as cine and delayed enhanced cardiac MR. Gated MPI data were processed using quantitative gated SPECT software. LV global function was assessed by measuring LV end-diastolic volume (EDV), endsystolic volume (ESV), and ejection fraction (EF). Regional function was assessed by quantifying segmental WM and WT according to the 17-segment model. Myocardial scarring was quantified on each segment using delayed enhanced cardiac MR. Agreement between SPECT and cardiac MR was assessed using Pearson correlation and Bland-Altman analyses. The influence of measurement magnitude on the agreement was analyzed using Spearman correlation coefficients between the mean and SD of measurements. The performance of WM and WT for the detection of segments with more than 25% scar transmurality was assessed using receiver-operating-characteristic analysis. Results: Correlation between methods was excellent for EF (R 5 0.81, P , 0.0001) and ESV (R 5 0.88, P , 0.0001) and was good for EDV (R 5 0.71, P , 0.0001). Agreement was good for EF (bias, 22.7%; limits of agreement, 215.5 to 110.1) but was lower for EDV (bias, 229.7 mL; limits of agreement, 268.3 to 18.9) and ESV (bias, 29.9 mL; limits of agreement, 230.7 to 110.9). Correlation between methods was fair for WM (R 5 0.49, P , 0.0001) and WT (R 5 0.48, P , 0.0001). SPECT underestimated WT (bias, 241%; limits of agreement, 2108 to 126), with an error depending on thickening magnitude (r 5 0.70, P , 0.0001). The agreement in WM measurement was higher (bias, 21.4 mm; limits of agreement, 26.9 to 14) and independent of motion magnitude (r 5 0.006, P 5 0.86). WM and WT were equally able to identify scarred segments (area under the receiver-operating-characteristic curve, 0.74 6 0.03 and 0.74 6 0.03, respectively). Conclusion: MPI using CZT SPECT cameras and quantitative gated SPECT analysis accurately quantifies EF but still underestimates LV volumes. WM shows a higher agreement with cardiac MR than does WT, with errors in WT measurement increasing at greater thicknesses. Absolute quantification of segmental WM and WT can equally be used to identify myocardial scarring.

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Section: Discussionsupporting

confidence: 93%

Absolute Quantification of Left Ventricular Global and Regional Function at Nuclear MPI Using Ultrafast CZT SPECT: Initial Validation Versus Cardiac MR

et al. 2013

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“…Due to the inferior temporal resolution of CCTA to 2DE, the peak velocity, E/A, and E/E' may have been underestimated. This limitation may be overcome by increasing the sampling rate or reducing the heart rate, if medically possible (10,14,29). Second, we applied simple exclusion criteria for selecting the study population, which consisted of patients who underwent cardiac surgery or coronary intervention.…”

Section: Discussionmentioning

confidence: 99%

Reliability in Using Routine Coronary CT Angiography with Retrospective Electrocardiographic Gating for the Comprehensive Functional Evaluation of the Left Ventricle

Kang

Hong

Park

et al. 2019

J Korean Soc Radiol

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Purpose To evaluate the feasibility of comprehensive left ventricle (LV) functional parameters on routine coronary computed tomographic angiography (CCTA) based on two-dimensional echocardiography (2DE). Materials and Methods Ninety-nine patients who underwent CCTA accompanied by 2DE were included in the study. The volumetric LV systolic functional parameters were acquired from 10-phase reconstruction of CCTA data. By differentiating the time-LV volume curve by time domain and measuring mitral valvular orifice areas, transmitral time-velocity curves were drawn and the early (E) to late (A) mitral inflow peak velocities ratio (E/A ratio) was acquired. By measuring a longitudinal jerking velocity of the mitral valvular annulus on a four-chamber view, the mitral peak velocity of early filling (E) to early diastolic mitral annular velocity (E') ratio (E/E' ratio) was evaluated. All functional parameters were compared with the 2DE results.

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“…When 16-frame gating is used, normal limits for PFR and time to PFR are similar to those reported with gated blood-pool studies. Agreement between SPECT and MRI in both PFR and time to PFR has been demonstrated when 32-frame gating is used for SPECT (48). Global time to PFR was shown to be less sensitive than regional parameters (49).…”

Section: Global LV Functionmentioning

confidence: 95%

Quantitative Clinical Nuclear Cardiology, Part 1: Established Applications

et al. 2019

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Learning Objectives: On successful completion of this activity, participants should be able to (1) know the basics of how quantitative parameters of relative left ventricular myocardial perfusion are measured and used clinically to differentiate patients with normal versus abnormal distributions; (2) know the basics of how quantitative parameters of left ventricular myocardial global and regional function is measured and used clinically to differentiate patients with normal versus abnormal function; and (3) describe and know how to use clinically nonperfusion quantitative parameters obtained from perfusion studies to modify the likelihood of the presence and extent of coronary artery disease in patients. Financial Disclosure: Dr. Moody is an employee of Invia. Dr. Slomka receives grants from the National Institutes of Health and Siemens Medical Systems and receives software royalties from Cedars-Sinai. Dr. Germano receives royalties from most nuclear medicine companies. Dr. Ficaro is an employee of Invia. Dr. Garcia receives grants from Syntermed and GE Healthcare and receives royalties from Syntermed. The authors of this article have indicated no other relevant relationships that could be perceived as a real or apparent conflict of interest. CME Credit: SNMMI is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing education for physicians. SNMMI designates each JNM continuing education article for a maximum of 2.0 AMA PRA Category 1 Credits. Physicians should claim only credit commensurate with the extent of their participation in the activity. For CE credit, SAM, and other credit types, participants can access this activity through the SNMMI website (http://www.snmmilearningcenter.org) through November 2022. SPECT myocardial perfusion imaging has attained widespread clinical acceptance as a standard of care for patients with known or suspected coronary artery disease. A significant contribution to this success has been the use of computer techniques to provide objective quantitative assessment in the standardization of the interpretation of these studies. Software platforms have been developed as a pipeline to provide the quantitative algorithms researched, developed and validated to be clinically useful so diagnosticians everywhere can benefit from these tools. The goal of this continuing medical education article (part 1) is to describe the many quantitative tools that are clinically established and, more importantly, how clinicians should use them routinely in interpretation, clinical management, and therapy guidance for patients with coronary artery disease.

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The agreement of left ventricular function parameters between 99mTc-tetrofosmin gated myocardial SPECT and gated myocardial MRI

Cited by 8 publications

References 45 publications

Absolute Quantification of Left Ventricular Global and Regional Function at Nuclear MPI Using Ultrafast CZT SPECT: Initial Validation Versus Cardiac MR

Absolute Quantification of Left Ventricular Global and Regional Function at Nuclear MPI Using Ultrafast CZT SPECT: Initial Validation Versus Cardiac MR

Reliability in Using Routine Coronary CT Angiography with Retrospective Electrocardiographic Gating for the Comprehensive Functional Evaluation of the Left Ventricle

Quantitative Clinical Nuclear Cardiology, Part 1: Established Applications

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