The Ah receptor: Mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds☆

Okey, Allan B.; Riddick, David S.; Harper, Patricia A.

doi:10.1016/0378-4274(94)90139-2

Cited by 356 publications

(161 citation statements)

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“…The Rel homology region (RHR) is known to be important both for dimerization of NF-kB/Rel subunits (Grimm and Baeuerle, 1993), as well as for interaction with many of these other proteins (Wissink et al, 1997;Stein et al, 1993). While some AhR domains involved in AhR binding to proteins, such as ARNT, hsp90, and the immunophilin-like ARA-9 protein have been evaluated (Perdew and Brad®eld, 1996;Meyer et al, 1998;Okey et al, 1994;Carver et al, 1998), those required for AhR dimerization with other proteins, e.g. Rb (Ge and Elferink, 1998), have not been de®ned.…”

Section: Discussionmentioning

confidence: 99%

The RelA NF-κB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells

et al. 2000

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Section: Discussionmentioning

confidence: 99%

The RelA NF-κB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells

et al. 2000

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“…The AHR appears to regulate the expression of several other genes, including those coding for drug-metabolizing enzymes and proteins that play key roles in cell growth and differentiation (Sutter and Greenlee. 1992;Okey et al. 1994a).…”

Section: Correlation Analysismentioning

confidence: 99%

Role of the aromatic hydrocarbon receptor in the suppression of cytochrome P-450 2C11 by polycyclic aromatic hydrocarbons

1997

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“…Those with coplanar conformations are referred to as dioxin-like PCBs in that, like dioxin, these PCBs are aryl hydrocarbon receptor (AhR) agonists [3]. The strongest AhR agonist among PCB congeners is 3, 3′, 4, 4′, 5 pentachlorobiphenyl (PCB 126) [4].…”

Section: Introductionmentioning

confidence: 99%

Perinatal polychlorinated biphenyl 126 exposure alters offspring body composition

2016

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Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants whose exposure levels are associated with various health hazards. We hypothesized that in utero and lactational exposure to PCBs can cause changes in body composition and obesity in a mouse model. Pregnant mice were exposed biweekly to two concentrations of PCB 126 via oral gavage. Maternal PCB exposure did not result in heavier offspring, however, dose-dependent and sex specific changes in body composition were observed. Female offspring displayed the most susceptibility to PCBinduced alterations in body composition, having less percent lean body mass and increased adiposity compared to females born to control dams, and these effects were largely dosedependent. In contrast to females, and independent of the exposure level of PCB 126, male offspring had reduced lean body mass but no change in fat mass compared to males born to control dams. In conclusion, perinatal PCB 126 exposure did not affect body weight, but rather modulated body composition in a dose-dependent and gender-specific manner.

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The Ah receptor: Mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds☆

Cited by 356 publications

References 100 publications

The RelA NF-κB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells

The RelA NF-κB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells

Role of the aromatic hydrocarbon receptor in the suppression of cytochrome P-450 2C11 by polycyclic aromatic hydrocarbons

Perinatal polychlorinated biphenyl 126 exposure alters offspring body composition

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