The alarmins high mobility group box protein 1 and S100A8/A9 display different inflammatory profiles after acute knee injury

Aulin, Cecilia; Larsson, S.; Vogl, Thomas; Roth, Johannes; Åkesson, Anna; Swärd, Per; Heinbäck, Rebecka; Harris, Helena Erlandsson; Struglics, A.

doi:10.1016/j.joca.2022.06.009

Cited by 4 publications

(3 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Once released, HMGB1 exerts a variety of inflammatory effects on these cells. The pro-inflammatory effect of HMGB1 is mainly due to its structural characteristics and derived cellular biological effects ( 9 ). A variety of receptors play a role in HMGB1 signaling, including receptors for advanced non-enzymatic glycation end products (RAGEs) and members of the Toll-like receptors (TLRs) ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

The clinical significance of serum HMGB1 in patients with lower extremity arteriosclerosis obliterans after interventional vascular restenosis

Yang

Zhang²

2023

Front. Surg.

View full text Add to dashboard Cite

ObjectiveThis study explored the correlation between serum HMGB1 levels and postoperative vascular restenosis in patients with lower extremity arteriosclerosis obliterans (LEASO).MethodsA total of 362 patients LEASO who received vascular intervention were recruited in this study. Serum HMGB1 levels were measured by enzyme-linked immunosorbent assay. Logistic regression analysis was used to identify the influencing factors associated with vascular restenosis. The R procedure was used to create nomogram model. Receiver operating characteristic (ROC) analysis was used to determine the predictive value of serum HMGB1 and nomogram model for vascular restenosis.ResultsOf the 362 LEASO patients included, 103 (28.45%) developed restenosis within 6 months of postoperative follow-up. Postoperative HMGB1 levels were significantly higher in patients with restenosis compared to those with non-restenosis. Postoperative HMGB1 levels were significantly and positively correlated with the severity of postoperative restenosis (r = 0.819). The AUC of postoperative HMGB1 for the diagnosis of postoperative restenosis was 0.758 (95% CI: 0.703–0.812), with a sensitivity and specificity of 56.31% and 82.24%, respectively. Multivariate logistic regression analysis showed that diabetes, smoking, regular postoperative medication, increased fibrinogen, decreased red blood cells, increased hs-CRP, and increased postoperative HMGB1 were independently associated with postoperative restenosis in patients with LEASO. The C-index of the nomogram prediction model constructed based on the seven influencing factors mentioned above was 0.918. The nomogram model was significantly more predictive of postoperative restenosis in LEASO patients compared with a single postoperative HMGB1 (AUC: 0.918, 95% CI: 0.757–0.934).ConclusionPostoperative serum HMGB1 is an independent risk factor associated with postoperative vascular restenosis in patients with LEASO, and a novel nomogram model based on postoperative serum HMGB1 combined with clinical characteristics may help to accurately predict the risk of postoperative restenosis in patients with LEASO.

show abstract

Section: Introductionmentioning

confidence: 99%

The clinical significance of serum HMGB1 in patients with lower extremity arteriosclerosis obliterans after interventional vascular restenosis

Yang

Zhang²

2023

Front. Surg.

View full text Add to dashboard Cite

show abstract

“…These differences were not as marked when compared with S100A8/A9 levels; in fact, S100A8/A9 expression in the acute injury group was deeply increased compared with the old-injury (317.54 vs. 3.07) and OA group (317.54 vs. 7.35). Additionally, HMGB1 is correlated with cartilage turnover makers [85]. Different results were reached by Ding et al: they reported that HMGB1 levels in synovial fluids from patients with chronic anterior cruciate ligament (ACL) injury were higher than in the acute group, but these results did not reach statistical significance [86].…”

Section: Role Of Hmgb1 In Osteoarthritismentioning

confidence: 97%

The Role of Alarmins in Osteoarthritis Pathogenesis: HMGB1, S100B and IL-33

Palumbo,

Atzeni,

Murdaca

et al. 2023

IJMS

View full text Add to dashboard Cite

Osteoarthritis (OA) is a multifactorial disease in which genetics, aging, obesity, and trauma are well-known risk factors. It is the most prevalent joint disease and the largest disability problem worldwide. Recent findings have described the role of damage-associated molecular patterns (DAMPs) in the course of the disease. In particular, alarmins such as HMGB1, IL-33, and S100B, appear implicated in enhancing articular inflammation and favouring a catabolic switch in OA chondrocytes. The aims of this review are to clarify the molecular signalling of these three molecules in OA pathogenesis, to identify their possible use as staging biomarkers, and, most importantly, to find out whether they could be possible therapeutic targets. Osteoarthritic cartilage expresses increased levels of all three alarmins. HMGB1, in particular, is the most studied alarmin with increased levels in cartilage, synovium, and synovial fluid of OA patients. High levels of HMGB1 in synovial fluid of OA joints are positively correlated with radiological and clinical severity. Counteracting HMGB1 strategies have revealed improving results in articular cells from OA patients and in OA animal models. Therefore, drugs against this alarmin, such as anti-HMGB1 antibodies, could be new treatment possibilities that can modify the disease course since available medications only alleviate symptoms.

show abstract

“…Therefore, BCP molecules can activate chondrocytes and synoviocytes through various signalling pathways [14]. High mobility group box 1 protein (HMGB1) and S100A8/A9 (calprotectin) are other DAMPs which can induce inflammatory mechanisms when released from dying or injured cartilage cells [15]. Moreover, released molecules induce inflammatory changes in the synovium which are characterised by stromal vascularisation, hyperplasia and fibrosis [16].…”

Section: Pattern Recognition Receptorsmentioning

confidence: 99%

The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis

Kiełbowski

Herian

Bakinowska

et al. 2023

IJMS

View full text Add to dashboard Cite

Osteoarthritis (OA) is progressive disease characterised by cartilage degradation, subchondral bone remodelling and inflammation of the synovium. The disease is associated with obesity, mechanical load and age. However, multiple pro-inflammatory immune mediators regulate the expression of metalloproteinases, which take part in cartilage degradation. Furthermore, genetic factors also contribute to OA susceptibility. Recent studies have highlighted that epigenetic mechanisms may regulate the expression of OA-associated genes. This review aims to present the mechanisms of OA pathogenesis and summarise current evidence regarding the role of genetics and epigenetics in this process.

show abstract

The alarmins high mobility group box protein 1 and S100A8/A9 display different inflammatory profiles after acute knee injury

Cited by 4 publications

References 45 publications

The clinical significance of serum HMGB1 in patients with lower extremity arteriosclerosis obliterans after interventional vascular restenosis

The clinical significance of serum HMGB1 in patients with lower extremity arteriosclerosis obliterans after interventional vascular restenosis

The Role of Alarmins in Osteoarthritis Pathogenesis: HMGB1, S100B and IL-33

The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis

Contact Info

Product

Resources

About