The Alberta Pregnancy Outcomes and Nutrition (APrON) cohort study: rationale and methods

Kaplan, Bonnie; Giesbrecht, Gerald F.; Leung, Brenda; Field, Catherine J.; Dewey, Deborah; Bell, Rhonda C.; Manca, Donna; O’Beirne, Maeve; Johnston, David W.; Pop, Victor J.M.; Singhal, Nalini; Gagnon, Lisa; Bernier, François P.; Eliasziw, Misha; McCargar, Linda J.; Kooistra, Libbe; Farmer, Anna; Cantell, Marja; Goonewardene, L. A.; Casey, Linda; Letourneau, Nicole; Martin, Jonathan W.; Team, APrON Study

doi:10.1111/j.1740-8709.2012.00433.x

Cited by 155 publications

(143 citation statements)

References 84 publications

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“…12 In brief, a modified Folch extraction was used to extract 300 µL plasma lipids, with separation of phospholipids from other major lipid classes by thin-layer chromatography, methylated using BF 3 . Fatty acids were separated and identified by automated gas liquid chromatography (Agilent GC model 7890a; Agilent Technologies, Santa Clara, CA) using a 100-m CP-Sil 88 fused capillary column (Varian Instruments, Mississauga, Ontario, Canada) as previously described.…”

Section: Plasma Fatty Acid Analysismentioning

confidence: 99%

Liver Disease, Systemic Inflammation, and Growth Using a Mixed Parenteral Lipid Emulsion, Containing Soybean Oil, Fish Oil, and Medium Chain Triglycerides, Compared With Soybean Oil in Parenteral Nutrition–Fed Neonatal Piglets

Turner

Josephson

Field

et al. 2015

J Parenter Enteral Nutr

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Section: Plasma Fatty Acid Analysismentioning

confidence: 99%

Liver Disease, Systemic Inflammation, and Growth Using a Mixed Parenteral Lipid Emulsion, Containing Soybean Oil, Fish Oil, and Medium Chain Triglycerides, Compared With Soybean Oil in Parenteral Nutrition–Fed Neonatal Piglets

Turner

Josephson

Field

et al. 2015

J Parenter Enteral Nutr

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“…The cohort comprises 2366 women recruited in the first trimester of pregnancy (8)(9)(10)(11)(12)(13)(14) …”

Section: Recruitmentmentioning

confidence: 99%

3D Cohort Study: The Integrated Research Network in Perinatology of Quebec and Eastern Ontario

Fraser

Shapiro

Audibert

et al. 2016

Paediatric Perinatal Epid

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Background: The 3D Cohort Study (Design, Develop, Discover) was established to help bridge knowledge gaps about the links between various adverse exposures during pregnancy with birth outcomes and later health outcomes in children. Methods: Pregnant women and their partners were recruited during the first trimester from nine sites in Quebec and followed along with their children through to 2 years of age. Questionnaires were administered during pregnancy and post-delivery to collect information on demographics, mental health and life style, medical history, psychosocial measures, diet, infant growth, and neurodevelopment. Information on the delivery and newborn outcomes were abstracted from medical charts. Biological specimens were collected from mothers during each trimester, fathers (once during the pregnancy), and infants (at delivery and 2 years of age) for storage in a biological specimen bank. Results: Of the 9864 women screened, 6348 met the eligibility criteria and 2366 women participated in the study (37% of eligible women). Among women in the 3D cohort, 1721 of their partners (1704 biological fathers) agreed to participate (73%). Two thousand two hundred and nineteen participants had a live singleton birth (94%). Prenatal blood and urine samples as well as vaginal secretions were collected for ≥98% of participants, cord blood for 81% of livebirths, and placental tissue for 89% of livebirths. Conclusions: The 3D Cohort Study combines a rich bank of multiple biological specimens with extensive clinical, life style, and psychosocial data. This data set is a valuable resource for studying the developmental etiology of birth and early childhood neurodevelopmental outcomes.

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“…Detailed information on recruitment criteria and data collection methodology has been published elsewhere (Kaplan et al 2014). Briefly, the inclusion criteria were females of childbearing age (>16 years), less than 26 weeks gestation, and able to speak and write in English.…”

Section: Participants and Sample Collectionmentioning

confidence: 99%

Women who take n-3 long-chain polyunsaturated fatty acid supplements during pregnancy and lactation meet the recommended intake

Xiao-ming

Pakseresht

Wattar

et al. 2015

Appl. Physiol. Nutr. Metab.

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Abstract:The aim of the current study was to estimate total intake and dietary sources of eicosapentaenoic acid (EPA), docosapentanoic (DPA), and docosahexaenoic acid (DHA) and compare DHA intakes with the recommended intakes in a cohort of pregnant and lactating women. Twenty-four-hour dietary recalls and supplement intake questionnaires were collected from 600 women in the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort at each trimester of pregnancy and 3 months postpartum. Dietary intake was estimated in 2 ways: by using a commercial software program and by using a database created for APrON. Only 27% of women during pregnancy and 25% at 3 months postpartum met the current European Union (EU) consensus recommendation for DHA. Seafood, fish, and seaweed products contributed to 79% of overall n-3 long-chain polyunsaturated fatty acids intake from foods, with the majority from salmon. The estimated intake of DHA and EPA was similar between databases, but the estimated DPA intake was 20%-30% higher using the comprehensive database built for this study. Women who took a supplement containing DHA were 10.6 and 11.1 times more likely to meet the current EU consensus recommendation for pregnancy (95% confidence interval (CI): 6.952-16.07; P < 0.001) and postpartum (95% CI: 6.803-18.14; P < 0.001), respectively. Our results suggest that the majority of women in the cohort were not meeting the EU recommendation for DHA during pregnancy and lactation, but taking a supplement significantly improved the likelihood that they would meet recommendations.

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The Alberta Pregnancy Outcomes and Nutrition (APrON) cohort study: rationale and methods

Cited by 155 publications

References 84 publications

Liver Disease, Systemic Inflammation, and Growth Using a Mixed Parenteral Lipid Emulsion, Containing Soybean Oil, Fish Oil, and Medium Chain Triglycerides, Compared With Soybean Oil in Parenteral Nutrition–Fed Neonatal Piglets

Liver Disease, Systemic Inflammation, and Growth Using a Mixed Parenteral Lipid Emulsion, Containing Soybean Oil, Fish Oil, and Medium Chain Triglycerides, Compared With Soybean Oil in Parenteral Nutrition–Fed Neonatal Piglets

3D Cohort Study: The Integrated Research Network in Perinatology of Quebec and Eastern Ontario

Women who take n-3 long-chain polyunsaturated fatty acid supplements during pregnancy and lactation meet the recommended intake

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