The ALBI score: From liver function in patients with HCC to a general measure of liver function

Toyoda, Hidenori; Johnson, Philip J.

doi:10.1016/j.jhepr.2022.100557

Cited by 60 publications

(50 citation statements)

References 150 publications

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“…The ALBI score serves as a prognostic score of liver function in patients with all stages of chronic liver disease and has been validated recently to assess prognosis in patients with hepatocellular carcinoma (HCC). 21 Based on a calculated algorithm including serum albumin and bilirubin levels, three different grades are distinguished ranging from good (grade 1) to poor prognosis (grade 3). Parameters of systemic inflammation: C-reactive protein (CRP) (normal range <0.5 mg/dl), neutrophil–lymphocyte ratio (NLR), leukocyte–lymphocyte ratio (LLR), monocyte–lymphocyte ratio (MLR), platelet–lymphocyte ratio (PLR) PVO (by thrombosis or tumor formation) as diagnosed by radiologists based on CT scans carried out during clinical routine …”

Section: Methodsmentioning

confidence: 99%

Clinical risk factors for ascites in metastatic pancreatic cancer

Berger¹,

Alany²,

Puhr³

et al. 2023

ESMO Open

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Section: Methodsmentioning

confidence: 99%

Clinical risk factors for ascites in metastatic pancreatic cancer

Berger¹,

Alany²,

Puhr³

et al. 2023

ESMO Open

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“…Patients who died had a significantly lower ALBI score than those who survived (2.8±0.4 vs 3.4±0.7, p < 0.001). Patients who died had a significantly lower GCS score (median [Q 1 -Q 3 ]; 8 [3][4][5][6][7][8][9][10][11][12][13] vs 15 [14][15], p < 0.001) but higher ISS (median [Q 1 -Q 3 ]; 33 [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] vs 20 [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29], p < 0.001) than the surviving patients.…”

Section: Comparison Of Patient and Injury Characteristics In Death An...mentioning

confidence: 99%

“…[15][16][17][18][19][20] It also functions as a crucial biomarker for the development of liver disease, reflecting the potential for hepatic failure and mortality from liver-related causes. [21][22][23][24][25][26][27] Patients with cholangiocarcinoma, 28 intrahepatic cholangiocarcinoma, 29 pancreatic cancer with liver metastases, 30 colorectal cancer with liver metastases, 31 and primary biliary cholangitis 32 can all benefit from knowing their ALBI grade as a prognostic indicator. Additionally, other non-hepatological disorders, including aortic dissection, 33 heart failure, 34,35 acute pancreatitis, 36 lung cancer, 24,37,38 esophageal cancer, 39 gastric cancer, 40 lung cancer, 41 and medulloblastoma, 42 have shown a high correlation between ALBI and death.…”

Section: Introductionmentioning

confidence: 99%

The Association of Albumin-Bilirubin (ALBI) Grade with Mortality Risk in Trauma Patients with Liver Injuries

Chou¹,

Rau²,

Su³

et al. 2023

RMHP

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Introduction The albumin-bilirubin (ALBI) grade objectively assesses liver function with better performance than the Child-Pugh and end-stage liver disease scores. However, the evidence is lacking on the ALBI grade in trauma cases. This study aimed to identify the association between the ALBI grade and mortality outcomes in trauma patients with liver injury. Methods Data from 259 patients with traumatic liver injury at a level I trauma center between January 1, 2009, and December 31, 2021 were retrospectively analyzed. Independent risk factors for predicting mortality were identified using multiple logistic regression analysis. Participants were characterized by ALBI score into grade 1 (≤ −2.60, n = 50), grade 2 (−2.60 < and ≤ −1.39, n = 180), and grade 3 (> −1.39, n = 29). Results Compared to survival (n = 239), death (n = 20) was associated with a significantly lower ALBI score (2.8±0.4 vs 3.4±0.7, p < 0.001). The ALBI score was a significant independent risk factor for mortality (OR, 2.79; 95% CI, 1.27–8.05; p = 0.038). Compared with grade 1 patients, grade 3 patients had a significantly higher mortality rate (24.1% vs 0.0%, p < 0.001) and a longer hospital stay (37.5 days vs 13.5 days, p < 0.001). Discussion This study showed that ALBI grade is a significant independent risk factor and an useful clinical tool to discover liver injury patients who are more susceptible to death.

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“…5,8 Recent review article has shown that the granularity of the ALBI score permitted to detect the early deterioration of liver function in patients with C-P class A. 9 There are two widely used albumin measurement methods: the bromocresol green (BCG) 10 and modified bromocresol purple (BCP) methods. 11 Laboratories in many countries use the BCG method; however, most laboratories in Japan are shifting to the modified BCP method because it does not cross-react with globulin, which has high specificity for albumin.…”

Section: Introductionmentioning

confidence: 99%

“…5,8 Recent review article has shown that the granularity of the ALBI score permitted to detect the early deterioration of liver function in patients with C-P class A. 9…”

Section: Introductionmentioning

confidence: 99%

Effect of albumin measurement methods on the albumin–bilirubin grade

Tanaka¹,

Tanaka²,

Suzuki³

et al. 2022

Ann Clin Biochem

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Background: Albumin-bilirubin (ALBI) grade is an index of liver function based on total bilirubin (T-BIL) and albumin levels, and its usefulness has been widely reported. This study aimed to investigate the effect of different methods of measuring T-BIL and albumin levels on the ALBI grade in patients with liver disease. Methods: In total, 170 patients from our hospital were included in this study. Correlations between T-BIL levels measured using the vanadate oxidation and enzymatic methods were analyzed. Similarly, a correlation analysis of albumin levels between the bromocresol green (BCG) and modified bromocresol purple (BCP) methods was performed. Additionally, the ALBI grade was calculated for patients with liver disease, and the differences between each method of albumin measurement were compared. Results: No differences were observed in the measured T-BIL values between the two methods. Contrastingly, the albumin levels of 100 random samples and 70 liver disease patients obtained using the modified BCP method were significantly lower than those measured using the BCG method. The rate of change in the modified ALBI grade between the BCG and BCP methods was 25.7%. Conclusions: Caution should be taken when comparing ALBI grades with those measured by other facilities because the method of albumin measurement can affect the ALBI grade. Standardization of albumin measurement is needed worldwide.

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The ALBI score: From liver function in patients with HCC to a general measure of liver function

Cited by 60 publications

References 150 publications

Clinical risk factors for ascites in metastatic pancreatic cancer

Clinical risk factors for ascites in metastatic pancreatic cancer

The Association of Albumin-Bilirubin (ALBI) Grade with Mortality Risk in Trauma Patients with Liver Injuries

Effect of albumin measurement methods on the albumin–bilirubin grade

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