The Albumin–Bilirubin Score Is a Prognostic Factor for Gastric Cancer Patients Who Receive Curative Treatment

Ju, Miwha; Aoyama, Toru; Komori, Keisuke; Tamagawa, Hiroshi; Tamagawa, Ayako; Maezawa, Yukio; Morita, Junya; Onodera, Atsushi; Endo, Kazuya; Hashimoto, Itaru; Kano, Kazuki; Hara, Kentaro; CHO, HARUHIKO; Nakazono, Masato; Segami, Kenki; Ishiguro, Tetsushi; Onuma, Shizune; Oshima, Takashi; Yukawa, Norio; Rino, Yasushi

doi:10.21873/anticanres.15887

Cited by 7 publications

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“…The present study evaluated the ALBI through the ROC curve based on the DFS for GC, and we set the cut-off value for the ALBI score at -2.82. Our cutoff score was similar to reported by Ju et al [ 21 ], that include only curative GC patients, where based on OS rates at 3 years and 5 years they determined an ALBI cutoff value of -2.78. Interestingly, a similar value was also found in a study with patients with esophageal cancer, where the cutoff value for the ALBI score was -2.7[ 10 ].…”

Section: Discussionmentioning

confidence: 61%

“…Classically, it is a biomarker intended to evaluate prognosis in patients with HCC, and the majority of available studies address this disease[ 20 ]. Even so, some articles report results of its application in other diseases[ 9 , 10 , 21 ]. For instance, Matsukane et al [ 22 ] reports that ALBI is an independent prognostic factor for patients with non-small cell lung cancer, and Lee et al [ 9 ] found that ALBI can predicted disease recurrence and survival in stage III colon cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Similar results have been reported by Zhu et al [ 14 ] that demonstrated worse OS for patients with GC and high ALBI values, especially those with stage disease II and III. Likewise, Ju et al [ 21 ] evaluating 244 patients with resected GC showed that increasing in ALBI levels was an independent factor related to OS, with a HR of 2.2. ALBI score was also related to recurrence in advanced GC stage as pT2-T4 after gastrectomy[ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Firstly, this is a retrospective research; therefore, some confounders and selection bias were not absolutely adjusted. Although ALBI grade has been related to the tolerability and introduction of postoperative adjuvant chemotherapy[ 21 , 32 ], since hepatic dysfunction are one of the main factors for adverse reactions to chemotherapy, it was not possible to assess the influences of the ALBI score on adherence to regimens and/or duration of chemotherapy. However, we believe that this limitation did not affect the results, since no difference in the frequency of patients treated with chemotherapy between low and high-ALBI groups was seen in our cohort.…”

Section: Discussionmentioning

confidence: 99%

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Preoperative albumin-bilirubin score is a prognostic factor for gastric cancer patients after curative gastrectomy

Szor¹,

Pereira²,

Ramos³

et al. 2023

World J Gastrointest Surg

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BACKGROUND Albumin-bilirubin (ALBI) score is an indicator of liver dysfunction and is useful for predicting prognosis of hepatocellular carcinomas. Currently, this liver function index has been used to predict prognosis in other neoplasms. However, the significance of ALBI score in gastric cancer (GC) after radical resection has not been elucidated. AIM To evaluate the prognostic value of the preoperative ALBI status in patients with GC who received curative treatment. METHODS Patients with GC who underwent curative intended gastrectomy were retrospectively evaluated from our prospective database. ALBI score was calculated as follows: (log10 bilirubin × 0.660) + (albumin × -0.085). The receiver operating characteristic curve with area under the curve (AUC) was plotted to evaluate the ability of ALBI score in predicting recurrence or death. The optimal cutoff value was determined by maximizing Youden’s index, and patients were divided into low and high-ALBI groups. The Kaplan-Meier curve was used to analyze the survival, and the log-rank test was used for comparison between groups. RESULTS A total of 361 patients (235 males) were enrolled. The median ALBI value for the entire cohort was -2.89 (IQR -3.13; -2.59). The AUC for ALBI score was 0.617 (95%CI: 0.556-0.673, P < 0.001), and the cutoff value was -2.82. Accordingly, 211 (58.4%) patients were classified as low-ALBI group and 150 (41.6%) as high-ALBI group. Older age ( P = 0.005), lower hemoglobin level ( P < 0.001), American Society of Anesthesiologists classification III/IV ( P = 0.001), and D1 lymphadenectomy P = 0.003) were more frequent in the high-ALBI group. There was no difference between both groups in terms of Lauren histological type, depth of tumor invasion (pT), presence of lymph node metastasis (pN), and pathologic (pTNM) stage. Major postoperative complication, and mortality at 30 and 90 days were higher in the high-ALBI patients. In the survival analysis, the high-ALBI group had worse disease-free survival (DFS) and overall survival (OS) compared to those with low-ALBI ( P < 0.001). When stratified by pTNM, the difference between ALBI groups was maintained in stage I/II and stage III CG for DFS ( P < 0.001 and P = 0.021, respectively); and for OS ( P < 0.001 and P = 0.063, respectively). In multivariate analysis, total gastrectomy, advanced pT stage, presence of lymph node metastasis and high-ALBI were independent factors associated with worse survival. CONCLUSION The preoperative ALBI score is able to predict the outcomes of patients with GC, where high-ALBI patients have worse prognosis. Also, ALBI score allows risk stratification of patients withi...

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Preoperative albumin-bilirubin score is a prognostic factor for gastric cancer patients after curative gastrectomy

Szor¹,

Pereira²,

Ramos³

et al. 2023

World J Gastrointest Surg

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show abstract

“…To date, various preoperative nutritional indices, calculated using peripheral blood data, have been reported as prognostic factors and evaluated by several studies (9)(10)(11)(12)(13)(14)(15)(16)(17)(18). However, efforts to search for a simpler and more composite index for the assessment of nutritional status in patients with GC remain inadequate.…”

mentioning

confidence: 99%

Significance of Preoperative Modified Nutritional Risk Index in Patients With Gastric Cancer After Curative Resection

WATANABE,

HASHIMOTO,

TANABE

et al. 2023

In Vivo

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Prognostic impact of combination therapy with gemcitabine and cisplatin plus S-1 and subsequent conversion surgery for initially unresectable upper biliary tract cancers

Kosaka,

Matsui,

Ikeura

et al. 2024

Surg Today

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The Albumin–Bilirubin Score Is a Prognostic Factor for Gastric Cancer Patients Who Receive Curative Treatment

Cited by 7 publications

References 0 publications

Preoperative albumin-bilirubin score is a prognostic factor for gastric cancer patients after curative gastrectomy

Preoperative albumin-bilirubin score is a prognostic factor for gastric cancer patients after curative gastrectomy

Significance of Preoperative Modified Nutritional Risk Index in Patients With Gastric Cancer After Curative Resection

Prognostic impact of combination therapy with gemcitabine and cisplatin plus S-1 and subsequent conversion surgery for initially unresectable upper biliary tract cancers

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