The alga Chlamydomonas reinhardtii UVS11 gene is responsible for cell division delay and temporal decrease in histone H1 kinase activity caused by UV irradiation

Slaninová, Miroslava; Nagyová, Barbara; Gálová, Eliška; Hendrychová, Jana; Bišová, Kateřina; Zachleder, Vilém; Vlček, Daniel

doi:10.1016/s1568-7864(03)00047-8

Cited by 11 publications

(13 citation statements)

References 44 publications

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“…BIŠOVÁ et al (2000) found that the activity of histone H1 kinases is related to the commitment points necessary for reproductive events in Desmodesmus quadricauda. This histone H1 kinase activity showed a decrease in Chlamydomonas reinhardtii in response to UV-induced DNA damage, which lead to a delay of mitosis and cell division (SLANINOVÁ et al, 2003). This may lead us to assume a possible link between UV-effects on H1 kinase activity and coenobium formation, howev-er, no direct proof of this has been found in the Desmodesmus and Scenedesmus genera so far and there is no evidence for UV-A-related effects on DNA.…”

Section: Discussionmentioning

confidence: 90%

Effects of UV‐A Radiation on Desmodesmus armatus: Changes in Growth Rate, Pigment Content and Morphological Appearance

Pálffy¹,

Vörös

2006

International Review of Hydrobiology

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Laboratory cultures of Desmodesmus armatus (R. CHOD.) HEGEW. were grown under different levels of photosynthetically active radiation (PAR) supplemented with 3.75 mW · cm -2 UV-A radiation. Growth rate was monitored daily, chlorophyl-a concentration, total carotenoid content, cell number and the relative abundance of different coenobial forms was determined at the end of each experiment. Exposure to UV-A radiation resulted in an increasing inhibition of growth towards higher PAR levels, reaching 100% at 400 µmol · m -2 · s -1 . Cellular carotenoid content was higher in the presence of UV-A radiation, on the other hand no differences were observed in cellular chlorophyll-a concentration. UV-A radiation also induced changes in coenobium formation with a decreasing proportion of 4-celled coenobia and an increase in the abundance of 2-celled and teratologic coenobia, suggesting that high intensity UV-A radiation may influence cell cycle events or morphology development.

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Section: Discussionmentioning

confidence: 90%

Effects of UV‐A Radiation on Desmodesmus armatus: Changes in Growth Rate, Pigment Content and Morphological Appearance

Pálffy¹,

Vörös

2006

International Review of Hydrobiology

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“…Our results have indicated that green alga C. reinhardtii possesses a control mechanism to arrest the cellcycle progression in response to DNA damage (Slaninová et al 2002(Slaninová et al , 2003. This "checkpoint" is likely to be activated just at the end of the growth phase, before the cell reproduction.…”

Section: Checkpoint Mutants In Chlamydomonasmentioning

confidence: 80%

“…The kinase activity could be a target process whose inhibition after UV irradiation leads to a delay in mitosis initiation. In contrast to the wild type, the UV-irradiated uvs11 cells did not show any substantial change, either in the course of kinase activities or in the cell-cycle progress, leading to the conclusion that uvs11 is a DNA-damage dependent checkpoint mutant (Slaninová et al 2003).…”

Section: Checkpoint Mutants In Chlamydomonasmentioning

confidence: 88%

“…Regarding DNA-damage dependent arrest, it has been reported that the kinase activity in C. reinhardtii wild type is suppressed for about five hours in response to UV irradiation followed by the recovery of the activity accompanied by a prolongation of the cell cycle (Slaninová et al 2003). The kinase activity could be a target process whose inhibition after UV irradiation leads to a delay in mitosis initiation.…”

Section: Checkpoint Mutants In Chlamydomonasmentioning

confidence: 99%

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Use of algae in the study of essential cell processes

et al. 2008

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Maintenance of genomic stability is of crucial importance for all living organisms. It is no surprise that during evolution, a series of highly selective and efficient systems to detect DNA damage and control its repair have evolved. To this end, signal transduction pathways are involved in pausing the cell division cycle to provide time for repair, and ultimately releasing the cell cycle from arrest. Genetic components of the damage and replication checkpoints have been identified and a working model is beginning to emerge. This area of biological inquiry has received a great deal of attention in the past decade with the realization that the underlying regulatory mechanisms controlling the cell cycle are conserved throughout eukaryotic evolution. Many of the key players in this response have structural and functional counterparts in species as diverse as yeast and human. In recent years attention has also been paid to the plant kingdom suggesting that checkpoint controls have been highly conserved during evolution. The unicellular green alga Chlamydomonas reinhardtii is a suitable model organism for the study of basic cellular processes including cell cycle regulation and DNA repair. To investigate how algal cells accomplish these tasks, we have isolated mutants in the recognition and repair of DNA damage or in the response to DNA damage.

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“…ellenőrzési pontok aktiválásával ké-pesek DNS-károsodás esetén a sejtciklus továbbhaladásának megakadályozá-sára. Elsősorban a C. reinhardtii UV-sugárzás okozta DNS-károsodásra érzé-keny uvs11 mutáns törzsével folytatott vizsgálatok engednek erre következtetni (Slaninová et al 2003). …”

Section: A Chlamydomonas Nemzetség Algáinak Biotechnológiai Kutatásaunclassified

A Chlamydomonas zöldalga nemzetség algáinak szerepe a biotechnológiában és helyük a zöldalgák rendszerében

Katona¹,

Molnár²,

Ördög³

2016

Botanikai közlemények

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The alga Chlamydomonas reinhardtii UVS11 gene is responsible for cell division delay and temporal decrease in histone H1 kinase activity caused by UV irradiation

Cited by 11 publications

References 44 publications

Effects of UV‐A Radiation on Desmodesmus armatus: Changes in Growth Rate, Pigment Content and Morphological Appearance

Effects of UV‐A Radiation on Desmodesmus armatus: Changes in Growth Rate, Pigment Content and Morphological Appearance

Use of algae in the study of essential cell processes

A Chlamydomonas zöldalga nemzetség algáinak szerepe a biotechnológiában és helyük a zöldalgák rendszerében

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