The Alimentary Lesion in Anaphylactoid Purpura

Anatomical Findings in a Case of Schönlein‐Henoch Syndrome: Relationship of this Condition to Collagen Diseases

“…The pathological anatomical finding obtained in this patient correspond withs those of the cases described in the literature (4,7,47,51).…”

“…The immunological process affects the vessels, causing dilatation of the venules after initial arteriolar contraction, and an increase in capillary permeability ( 5 2 ) . Thus the picture of "acute regional enteritis" is produced (4), with hyperaemia, oedema and haemorrhage of the intestinal wall. Baff (4) suggests that circulatory changes may occur due to arteriolar spasm of the submucosa; shunts in the submucosa then lead the major part of the blood stream to the external layers of the intestinal wall.…”

Intestinal ultrasonographic findings in Schönlein-Henoch syndrome

“…So far, reports of haemorrhage and oedema in the gastro-intestinal tract have been based on radiological examinations and in situ findings during surgery [2,3,5,6]. The present study reports on the results of intestinal ultrasonography in children with SHS and abdominal pain.…”

Purpura Fulminans in a Newborn Baby

“…The syndromes of purpura fulminans, thrombotic thrombocytopenic purpura (thrombotic microangiopathic haemolytic anaemia or Moschcowitz's syndrome), periarteritis nodosa and anaphylactoid purpura (Henoch-Schonlein purpura) all have an obscure aetiology and pathogenesis. Many authors (Crawford and Riddler, 1959;Heal and Kent, 1953;Chambers et al, 1952;Turin et al, 1959;Seinfeld et al, 1960;Balf, 1951;Kingsley and Aquino, 1958;Craig and Gitlin, 1957;Wile and Sturgeon, 1956;Gairdner, 1948;Robinson, Orchard and Eden, 1958;Vernier, Worthen, Peterson, Colle and Good, 1961) feel that the primary fault appears to be a focal vascular lesion with swelling of the endothelium, rupture of the vessel wall and haemorrhage. These authorities have suggested independently that each disease is primarily a vascular disorder caused by an abnormal immunological mechanism of unknown origin.…”

“…Although opinion is divided, it is probable that such a reaction can occur in man. Balf (1951) discusses the alimentary lesion in anaphylactoid purpura where a large part of the intestinal tract is affected. It is interesting to note also that many sections of the gastro-intestinal tract are similarly damaged in the generalized Shwartzman reaction.…”