2000
DOI: 10.1016/s1383-5718(00)00014-0
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The alkaline single cell electrophoresis assay with eight mouse organs: results with 22 mono-functional alkylating agents (including 9 dialkyl N-nitrosoamines) and 10 DNA crosslinkers

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Cited by 54 publications
(32 citation statements)
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“…To obtain nuclei, the homogenate was centrifuged at 700 g for 10 min at 08C, and the precipitate was resuspended in chilled homogenizing buffer at 0.5 g=mL and allowed to settle; precipitated clumps were then removed. Doses and times were selected based on the preliminary studies as well as literature-reported values (Sasaki et al, 1997a(Sasaki et al, , 1997bTsuda et al, 2000;Sekihashi et al, 2002).…”
Section: Treatment and Organ Preparationmentioning
confidence: 99%
“…To obtain nuclei, the homogenate was centrifuged at 700 g for 10 min at 08C, and the precipitate was resuspended in chilled homogenizing buffer at 0.5 g=mL and allowed to settle; precipitated clumps were then removed. Doses and times were selected based on the preliminary studies as well as literature-reported values (Sasaki et al, 1997a(Sasaki et al, , 1997bTsuda et al, 2000;Sekihashi et al, 2002).…”
Section: Treatment and Organ Preparationmentioning
confidence: 99%
“…The control groups were not treated with any chemical and the euthanized, chemical-treated groups were intraperitoneally treated with MMS (80 mg/kg) or DEN (160 mg/ kg). The doses of MMS and DEN were based on a report by Tsuda et al (Tsuda et al, 2000).…”
Section: Treatment and Samplingmentioning
confidence: 99%
“…This procedure has been widely used for genotoxicity studies (McKelvey-Martin et al, 1993) and for monitoring the exposure to DNAdamaging agents in human populations (Moller et al, 2000). It has also been applied to neurons exposed to genotoxic compounds or electromagnetic fields (Malyapa et al, 1998;Svedenstal et al, 1999;Tsuda et al, 2000), but was never used to investigate DNA breaks in postischemic brain damage or other neurologic disorders.…”
mentioning
confidence: 99%