The Alkaloids of Tabernanthe iboga. Part III.¹ Isolation Studies

Ibogaine and the inhibition of acetylcholinesterase

“…The relative AChE inhibition activity of ibogaine compared to physostigmine observed in this study is approximately an order of magnitude less than the earlier results reported by Vincent et al, and suggests that the crystallisate in their study may have contained other compounds that inhibit AChE. Voacangine has been isolated from T. iboga root bark (Dickel et al, 1958) and reportedly inhibits AChE at the same concentration as the reference compounds physostigmine and galantamine (Andrade et al, 2005). Ibogaine co-occurs with voacangine in T. divaricata (Kam et al, 2004), a species that produces particularly strong AChE inhibition among plants used in Thai traditional medicine (Ingkaninan et al, 2003), and other alkaloid and non-alkaloid constituents of T. divaricata that could inhibit AChE (Chattipakorn et al, 2007) might possibly co-occur with ibogaine in T. iboga as well.…”

Fatalities Temporally Associated with the Ingestion of Ibogaine

“…40% ibogaine, 10% related iboga alkaloids, and 50% other alkaloids, whereas utilization of an organic solvent such as acetone or methanol yields a total alkaloid fraction with relatively less non‐iboga alkaloid content (157). Other iboga alkaloids that co‐occur with ibogaine in T. iboga root bark include ibogamine, ibogaine, tabernanthine, and voacangine (157–159) (see Fig. 1).…”

Alkaloid Studies VIII: Isolation and Characterization of Alkaloids of Tabernaemontana Heyneana Wall and Antifertility Properties of Coronaridine

“…One fraction yielded a crystalline alkaloid which was identified as ibogamine (VII) (7)(8)(9). One fraction yielded a crystalline alkaloid which was identified as ibogamine (VII) (7)(8)(9).…”