The Alleviative Efficacy of Vitamins A, C, and E Against Zinc Oxide Nanoparticles-Induced Hepatic Damage by Reducing Apoptosis in Rats

Daei, Sajedeh; Abbasalipourkabir, Roghayeh; Khajvand-Abedini, Maryam; Ziamajidi, Nasrin

doi:10.1007/s12011-022-03218-2

Cited by 6 publications

(4 citation statements)

References 48 publications

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“…Taken together, according to the present research and resent papers, 20 25 treatment with VA, C, and E may prevent ZnO NPs-caused toxicity by reducing oxidative damage and apoptosis.…”

Section: Discussionsupporting

confidence: 68%

“…In a previous report, we found that ZnO NPs promote apoptosis in rats’ liver, where the NPs altered the protein and gene expression of Bax and Bcl-2. 25 In addition to ZnO NPs, it was reported that nano-copper could affect the expression of apoptotic genes in the rat testicular tissue as the mRNA expression of caspase 3 and Bax was increased, and Bcl-2 expression was downregulated in the 175 mg/kg-treated group. 11 …”

Section: Discussionmentioning

confidence: 99%

“…A population of 54 male healthy Wistar rats with an average weight of 200±15 g were procured from the Animal Care Center-Hamadan University of Medical Sciences (Hamadan, Iran) and maintained under standard conditions according to our previous study. 25 …”

Section: Methodsmentioning

confidence: 99%

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Vitamins A, C, and E Exert Anti-apoptotic Function in the Testis of Rats After Exposure to Zinc Oxide Nanoparticles

et al. 2023

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Some reports emphasize that zinc oxide nanoparticles (ZnO NPs) are detrimental to the reproductive organs of animals. As such, this research aimed at exploring the apoptotic potential of ZnO NPs on testis along with the beneficial role of Vitamins (V) A, C, and E against ZnO NP-induced damage. To this aim, a population of 54 healthy, male Wistar rats were used in this work and then assigned into nine groups of 6 rats as G1: Control 1 (Water); G2: Control 2 (Olive oil); G3: VA (1000 IU/kg), G4: VC (200 mg/kg), G5: VE (100 IU/kg), G6: ZnO NPs exposed animals (200 mg/kg); and G7, 8 and 9: ZnO NPs-exposed animals that were pre-treated with either VA, C, or E. Apoptosis rates were estimated by measuring the level of apoptotic regulatory markers including Bcl-2-associated X (Bax) and B-cell lymphoma protein 2 (Bcl-2) using western blotting and qRT-PCR assays. The data indicated that ZnO NPs exposure elevates the level of Bax protein and gene expression, whereas the protein and gene expression of Bcl-2 was reduced. Further, the activation of caspase-3,7 occurred after exposure to ZnO NPs, while the above alterations were significantly alleviated in the rats that were co-treated with VA, C, or E and ZnO NPs relative to the rats in the ZnO NPs group. In summary, VA, C, and E exerted anti-apoptotic functions in the testis of rats following administration of ZnO NPs.

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“…Taken together, according to the present research and resent papers, 20 25 treatment with VA, C, and E may prevent ZnO NPs-caused toxicity by reducing oxidative damage and apoptosis.…”

Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Vitamins A, C, and E Exert Anti-apoptotic Function in the Testis of Rats After Exposure to Zinc Oxide Nanoparticles

et al. 2023

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“…Due to this, they have been found in numerous products including food preservatives, sunscreens in cosmetics, textile coatings, agricultural fertilizers, and several biomedical applications [2]. Numerous in vivo studies [3][4][5][6] have shown the harmful effects of ZnO NPs on many organs. Additionally, it has been shown that nanoparticles may cross the blood-testis barrier (BTB) and harm the testis [2].…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effects of Vitamins A, C, and E on Sperm Parameters, Testis Histopathology, and Oxidative Stress Status in Zinc Oxide Nanoparticle‐Treated Rats

Ziamajidi

Khajvand-Abedini

Daei

et al. 2023

BioMed Research International

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One of the most often utilized nanoparticles (NPs) in several technologies is zinc oxide (ZnO) NPs. However, these NPs are said to have harmful effects on the reproductive system. Thus, we designed this study to specify the potential preventive activity of vitamins (Vits) A, C, and E, as antioxidants, against toxicity of ZnO NPs in the testes of rats. A total of 54 Wistar rats were arranged in 9 groups of 6 and then orally received water (control 1), olive oil (control 2), Vit A (1000 IU/kg), Vit C (200 mg/kg), Vit E (100 IU/kg), ZnO (200 mg/kg), ZnO+Vit A, ZnO+Vit C, and ZnO+Vit E. To determine the amount of testicular injury, sperm analysis and histological evaluation were performed. In addition, oxidative stress status was examined using colorimetric and qRT-PCR methods. Our findings suggest that ZnO NPs cause adverse effects on sperm parameters and testicular histology. Furthermore, oxidative biomarkers (malondialdehyde and total oxidant capacity) were enhanced in the ZnO group. By contrast, the gene expression and activities of antioxidant enzymes (SOD, GPx, and CAT) noted a remarkable decrease in the ZnO group regarding control ( p < 0.05 ). However, oxidative markers were remarkably mitigated after combined treatment of ZnO NPs and Vits A, C, or E compared to the rats given ZnO NPs ( p < 0.05 ). Additionally, compared to the ZnO NP group, the rats receiving Vits+ZnO NPs exhibit increased antioxidant enzyme activity and mRNA expression ( p < 0.05 ). The findings demonstrate the abovementioned Vits’ ameliorative effects on toxicity incurred by ZnO NPs.

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The antioxidant and anti-apoptotic properties of vitamins A, C and E in heart tissue of rats exposed to zinc oxide nanoparticles

et al. 2022

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The Alleviative Efficacy of Vitamins A, C, and E Against Zinc Oxide Nanoparticles-Induced Hepatic Damage by Reducing Apoptosis in Rats

Cited by 6 publications

References 48 publications

Vitamins A, C, and E Exert Anti-apoptotic Function in the Testis of Rats After Exposure to Zinc Oxide Nanoparticles

Vitamins A, C, and E Exert Anti-apoptotic Function in the Testis of Rats After Exposure to Zinc Oxide Nanoparticles

Ameliorative Effects of Vitamins A, C, and E on Sperm Parameters, Testis Histopathology, and Oxidative Stress Status in Zinc Oxide Nanoparticle‐Treated Rats

The antioxidant and anti-apoptotic properties of vitamins A, C and E in heart tissue of rats exposed to zinc oxide nanoparticles

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