1986
DOI: 10.1002/bimj.4710280510
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The Almost‐one Parameter Hypothesis Applied to Pharmacokinetics of Ethanol Infusion

Abstract: They say that the pharmecokinetice of constant-rate intravenous infusion of ethanol obeys the Henri-Michaelis-Menten (H-M-M) model. In analping the original data from the viewpoint of the almost-one parameter hypotheeis (see box 1). we found that the whole procees should be divided info four phasee and the H-M-M model was valid only in the last phase.

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Cited by 6 publications
(2 citation statements)
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“…The curve has found application, for example, in growth populations with confined space or limited nutrients. Masuyama (1979Masuyama ( , 1985Masuyama ( , 1988Masuyama ( , 1991Masuyama ( , 1992, for example, notes that several growth processes including human stature appear to be biphasic, with some individuals demonstrating an initially slower rate of growth accompanied by more rapid growth at later ages and vice versa. As such, the pattern of growth is different than for the more widely used logistic curve, which has a symmetric inflection point.…”
Section: Monte Carlo Examination Of Model Comparisonmentioning
confidence: 99%
“…The curve has found application, for example, in growth populations with confined space or limited nutrients. Masuyama (1979Masuyama ( , 1985Masuyama ( , 1988Masuyama ( , 1991Masuyama ( , 1992, for example, notes that several growth processes including human stature appear to be biphasic, with some individuals demonstrating an initially slower rate of growth accompanied by more rapid growth at later ages and vice versa. As such, the pattern of growth is different than for the more widely used logistic curve, which has a symmetric inflection point.…”
Section: Monte Carlo Examination Of Model Comparisonmentioning
confidence: 99%
“…Let the rate constant of a substance in blood be k. Then k is determined in principle by heredity, and X of this substance is a linear function of U=log k (MASUYAMA, 1979b(MASUYAMA, , 1984. In other word8, SD of X, say a,, under standard condition is determined in principle by heredity.'…”
Section: Introductionmentioning
confidence: 99%