“…In fact, a cirrhotic liver is less capable for hypertrophy after PVE than is a healthy liver. Vennarecci et al (54) found that i) the ALLPS procedure is technically feasible and safe even when performing a major liver resection to treat HCC in a cirrhotic liver, that ii) the procedure is able to induce a significant increase in the volume of the FLR in a short period of time, allowing completion of the second stage of ALPPS, and that iii) the volume of face the challenge of choosing either resection of the hepatic tumor with a potential risk of postoperative liver failure (PHLF) or giving the patient palliative treatment, such as transcatheter arterial chemoembolization or local ablative therapy, to avoid PHLF if the volume of the FLR is on the borderline (39,40). In recent years, some strategies, such as portal vein ligation (PVL), portal vein embolization (PVE), and two-stage liver resection have been developed to induce hypertrophy of the FLR prior to hepatectomy in primarily non-resectable liver tumors (41).…”