The Alteration human of gut microbiota and metabolites before and after renal transplantation

Yu, Dong; Niu, Ying; Lian, Zhao; Fa, Ye Qi

doi:10.1016/j.micpath.2021.105191

Cited by 7 publications

(3 citation statements)

References 25 publications

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“…The relevant data support the interconnection between gut microbial profiles and the outcomes in renal transplantation [ 149 ]. Great amounts of research have highlighted that the microflora alteration is induced by the elevated administration of immunosuppressants and antimicrobial-prophylactic drugs to prevent graft failure and infections.…”

Section: Fmt and Kidney Diseasementioning

confidence: 93%

“…Magruder et al demonstrated that dysbiosis could be connected with the occurrence of a urinary tract infection (UTI) in transplanted patients [ 153 ]. As mentioned previously, the evaluation of metabolic profiles has been considered a hallmark of bacterial richness and diversity [ 149 ]. Poesen and colleagues observed that PBUTs derived from kidney-transplanted patients were reduced in patients with CKD [ 117 ].…”

Section: Fmt and Kidney Diseasementioning

confidence: 99%

See 1 more Smart Citation

Fecal Microbiota Transplantation in Reducing Uremic Toxins Accumulation in Kidney Disease: Current Understanding and Future Perspectives

Caggiano

Stasi

Franzin

et al. 2023

Toxins

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During the past decades, the gut microbiome emerged as a key player in kidney disease. Dysbiosis-related uremic toxins together with pro-inflammatory mediators are the main factors in a deteriorating kidney function. The toxicity of uremic compounds has been well-documented in a plethora of pathophysiological mechanisms in kidney disease, such as cardiovascular injury (CVI), metabolic dysfunction, and inflammation. Accumulating data on the detrimental effect of uremic solutes in kidney disease supported the development of many strategies to restore eubiosis. Fecal microbiota transplantation (FMT) spread as an encouraging treatment for different dysbiosis-associated disorders. In this scenario, flourishing studies indicate that fecal transplantation could represent a novel treatment to reduce the uremic toxins accumulation. Here, we present the state-of-the-art concerning the application of FMT on kidney disease to restore eubiosis and reverse the retention of uremic toxins.

show abstract

Section: Fmt and Kidney Diseasementioning

confidence: 93%

Section: Fmt and Kidney Diseasementioning

confidence: 99%

Fecal Microbiota Transplantation in Reducing Uremic Toxins Accumulation in Kidney Disease: Current Understanding and Future Perspectives

Caggiano

Stasi

Franzin

et al. 2023

Toxins

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“…Other studies on the gut microbiota after kidney transplantation (KT) reported a reduction in Faecalibacterium [ 2 ], reduction in Actinobacteria and Faecalibacterium prausnizii [ 3 ], reduction in Ruminococcaceae [ 4 ], and reduction in Clostridiales [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Update on the reciprocal interference between immunosuppressive therapy and gut microbiota after kidney transplantation

Salvadori,

Rosso

2024

World J Transplant

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Gut microbiota is often modified after kidney transplantation. This principally happens in the first period after transplantation. Antibiotics and, most of all, immunosuppressive drugs are the main responsible. The relationship between immunosuppressive drugs and the gut microbiota is bilateral. From one side immunosuppressive drugs modify the gut microbiota, often generating dysbiosis; from the other side microbiota may interfere with the immunosuppressant pharmacokinetics, producing products more or less active with respect to the original drug. These phenomena have influence over the graft outcomes and clinical consequences as rejections, infections, diarrhea may be caused by the dysbiotic condition. Corticosteroids, calcineurin inhibitors such as tacrolimus and cyclosporine, mycophenolate mofetil and mTOR inhibitors are the immunosuppressive drugs whose effect on the gut microbiota is better known. In contrast is well known how the gut microbiota may interfere with glucocorticoids, which may be transformed into androgens. Tacrolimus may be transformed by microbiota into a product called M1 that is 15-fold less active with respect to tacrolimus. The pro-drug mycophenolate mofetil is normally transformed in mycophenolic acid that according the presence or not of microbes producing the enzyme glucuronidase, may be transformed into the inactive product.

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Facile preparation of nitrogen/titanium-rich porous organic polymers for specific enrichment ofN-glycopeptides and phosphopeptides

Wang,

Zhang,

Yan

et al. 2024

Anal. Methods

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The Alteration human of gut microbiota and metabolites before and after renal transplantation

Cited by 7 publications

References 25 publications

Fecal Microbiota Transplantation in Reducing Uremic Toxins Accumulation in Kidney Disease: Current Understanding and Future Perspectives

Fecal Microbiota Transplantation in Reducing Uremic Toxins Accumulation in Kidney Disease: Current Understanding and Future Perspectives

Update on the reciprocal interference between immunosuppressive therapy and gut microbiota after kidney transplantation

Facile preparation of nitrogen/titanium-rich porous organic polymers for specific enrichment ofN-glycopeptides and phosphopeptides

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