The Alteration of Brain Interstitial Fluid Drainage with Myelination Development

Wang, Rui; Han, Hongbin; Shi, Kuangyu; Alberts, Ian; Rominger, Axel; Yang, Chenlong; Yan, Junhao; Cui, Dehua; Peng, Yun; He, Qichun; Gao, Yajuan; Lian, Jingge; Yang, Shangqi; Liu, Huipo; Yang, Jun; Wong, Chaolan; Wei, Xunbin; Yin, Feng; Jia, Yanxing; Tong, Huaiyu; Liu, Bo; Lei, Jianbo

doi:10.14336/ad.2021.0305

Cited by 14 publications

(10 citation statements)

References 35 publications

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“…In areas affected by stroke, remyelination is important in the process of functional recovery (Park et al, 2022). Intact myelin can serve as a barrier structure for ISF drainage, which is beneficial for the development of cognitive and motor or sensory abilities of the brain (Wang et al, 2021). This may explain why the association between the ipsilateral DTI-ALPS index and the contralateral CST in our study may be related to CST axonal remodeling and the clearance function of the glymphatic system.…”

Section: Association Between Damaged Glymphatic System and Cst In Str...mentioning

confidence: 68%

DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke

Qin

Li²,

Qiao

et al. 2023

Front. Neurosci.

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PurposeBrain glymphatic dysfunction is involved in the pathologic process of acute ischemic stroke (IS). The relationship between brain glymphatic activity and dysfunction in subacute IS has not been fully elucidated. Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index was used in this study to explore whether glymphatic activity was related to motor dysfunction in subacute IS patients.MethodsTwenty-six subacute IS patients with a single lesion in the left subcortical region and 32 healthy controls (HCs) were recruited in this study. The DTI-ALPS index and DTI metrics (fractional anisotropy, FA, and mean diffusivity, MD) were compared within and between groups. Spearman's and Pearson's partial correlation analyses were performed to analyze the relationships of the DTI-ALPS index with Fugl-Meyer assessment (FMA) scores and with corticospinal tract (CST) integrity in the IS group, respectively.ResultsSix IS patients and two HCs were excluded. The left DTI-ALPS index of the IS group was significantly lower than that of the HC group (t = −3.02, p = 0.004). In the IS group, a positive correlation between the left DTI-ALPS index and the simple Fugl-Meyer motor function score (ρ = 0.52, p = 0.019) and a significant negative correlation between the left DTI-ALPS index and the FA (R = −0.55, p = 0.023) and MD (R = −0.48, p = 0.032) values of the right CST were found.ConclusionsGlymphatic dysfunction is involved in subacute IS. DTI-ALPS could be a potential magnetic resonance (MR) biomarker of motor dysfunction in subacute IS patients. These findings contribute to a better understanding of the pathophysiological mechanisms of IS and provide a new target for alternative treatments for IS.

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Section: Association Between Damaged Glymphatic System and Cst In Str...mentioning

confidence: 68%

DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke

Qin

Li²,

Qiao

et al. 2023

Front. Neurosci.

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“…Five rats were randomly selected from Sham group and SAH group respectively (n = 5) for these experiments. The MRI tracer Gd-DTPA is impermeable to the neuronal membrane and evenly distributed within ISF, and had been demonstrated as a good indicator for ISF drainage [ 32 ]. In this study, Gd-DTPA was diluted to 10 mmol/L in normal saline solution and injected into the frontal cortex of rats.…”

Section: Methodsmentioning

confidence: 99%

The impairment of intramural periarterial drainage in brain after subarachnoid hemorrhage

Sun

Liu

Pei

et al. 2022

acta neuropathol commun

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Interstitial fluid (ISF) from brain drains along the basement membranes of capillaries and arteries as Intramural Periarterial Drainage (IPAD); failure of IPAD results in cerebral amyloid angiopathy (CAA). In this study, we test the hypothesis that IPAD fails after subarachnoid haemorrhage (SAH). The rat SAH model was established using endovascular perforation method. Fluorescence dyes with various molecular weights were injected into cisterna magna of rats, and the pattern of IPAD after SAH was detected using immunofluorescence staining, two-photon fluorescent microscope, transmission electron microscope and magnetic resonance imaging tracking techniques. Our results showed that fluorescence dyes entered the brain along a periarterial compartment and were cleared from brain along the basement membranes of the capillaries, with different patterns based on individual molecular weights. After SAH, there was significant impairment in the IPAD system: marked expansion of perivascular spaces, and ISF clearance rate was significantly decreased, associated with the apoptosis of endothelial cells, activation of astrocytes, over-expression of matrix metalloproteinase 9 and loss of collagen type IV. In conclusion, experimental SAH leads to a failure of IPAD, clinically significant for long term complications such as CAA, following SAH.

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“…Animals were housed under a 12hour light/dark diurnal cycle, temperature of 22±1°C, and humidity of 60±5%. Animals were provided ad libitum access to food and clean drinking water [13].…”

Section: Experimental Animalsmentioning

confidence: 99%

“…The MWM test was conducted to assess spatial learning and memory capability of rats in the Con 7 and EAI 7 groups as previously described [13,22]. On day 1, rats were pretrained to find a visual platform, which was 1 cm above the surface of the water, to adapt to the test procedure.…”

Section: Behavioral and Cognitive Assessmentsmentioning

confidence: 99%

“…Brain ISF drains bidirectionally from the Cn toward the cortex and thalamus in juvenile rats. In contrast, in the adult brain, it drains only toward the ipsilateral cortex along the mature myelin sheath [12,13]. The exchange of ISF-cerebrospinal fluid (CSF) occurs in the superficial cortex with the assistance of arterial pulsation and then enters the subarachnoid space (SAS) [14], which then drains to the deep cervical lymph nodes via the epidural lymph vessels and flows into the somatic circulation [15].…”

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confidence: 99%

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Epidural Pulsation Accelerates the Drainage of Brain Interstitial Fluid

Cai¹,

He²,

Wang³

et al. 2023

Aging and disease

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Unhindered transportation of substances in the brain extracellular space (ECS) is essential for maintaining brain function. Regulation of transportation is a novel strategy for treating ECS blockage-related brain diseases, but few techniques have been developed to date. In this study, we established a novel approach for accelerating the drainage of brain interstitial fluid (ISF) in the ECS using minimally invasive surgery, in which a branch of the external carotid artery is separated and implanted epidurally (i.e., epidural arterial implantation [EAI]) to promote a pulsation effect on cerebrospinal fluid (CSF) in the frontoparietal region. Tracer-based magnetic resonance imaging was used to evaluate the changes in ISF drainage in rats 7 and 15 days post-EAI. The drainage of the traced ISF from the caudate nucleus to ipsilateral cortex was significantly accelerated by EAI. Significant increases in the volume fraction of the ECS and molecular diffusion rate were demonstrated using the DECS-mapping technique, which may account for the mechanisms underlying the changes in brain ISF. This study provides a novel perspective for encephalopathy treatment via the brain ECS.

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The Alteration of Brain Interstitial Fluid Drainage with Myelination Development

Cited by 14 publications

References 35 publications

DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke

DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke

The impairment of intramural periarterial drainage in brain after subarachnoid hemorrhage

Epidural Pulsation Accelerates the Drainage of Brain Interstitial Fluid

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