2020
DOI: 10.21873/anticanres.14155
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The Alterations in Alcohol Dehydrogenase Activity in the Sera of Women With Intrahepatic Cholestasis of Pregnancy

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Cited by 18 publications
(12 citation statements)
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“… 28 , 29 It is thus meaningful to find disease markers for the identification and prevention of adverse fetal outcome of patients with ICP or gestational cholestasis as early and precisely as possible. Recently, some potential parameters, including serum total ADH activity 30 and bile acid profile, 31 were also identified as useful for monitoring the progression of ICP. Hydrophobic bile acids can undermine the integrity of cell membranes by disrupting lipid components 32 and promote cell apoptosis.…”
Section: Discussionmentioning
confidence: 99%
“… 28 , 29 It is thus meaningful to find disease markers for the identification and prevention of adverse fetal outcome of patients with ICP or gestational cholestasis as early and precisely as possible. Recently, some potential parameters, including serum total ADH activity 30 and bile acid profile, 31 were also identified as useful for monitoring the progression of ICP. Hydrophobic bile acids can undermine the integrity of cell membranes by disrupting lipid components 32 and promote cell apoptosis.…”
Section: Discussionmentioning
confidence: 99%
“…The measurement of bile acid concentration is a basic test aimed at diagnosis and therapy monitoring of the ICP. Meanwhile, the activity of alcohol dehydrogenase (ADH) isoenzymes could be considered as having a positive interaction in the sera of women with intrahepatic cholestasis 14 and having a history of allergic reactions may mean they are more likely to develop ICP 15 but for our patient there was no history of allergic reactions. Hence it is better to consider such a test while suspecting and detecting this case.…”
Section: Discussionmentioning
confidence: 89%
“…Chen et al ( 23) have reported MMP-2 and MMP-9 serum levels exhibited a progressive and significant elevation in mild and severe ICP patients compared with healthy pregnant women, indicating MMP-2 and MMP-9 could be reliably used as laboratory abnormalities for accurate diagnosis and sensitive grading of ICP in Chinese population. Jelski et al (24) have reported the total ADH activity and class I ADH isoenzymes was significantly higher in women with ICP than in healthy pregnant, indicating that the activity of class I ADH isoenzymes may have a diagnostic significance. However, there are few studies on biomarkers for simultaneous diagnosis and prediction of ICP.…”
Section: Discussionmentioning
confidence: 99%
“…Jelski et al. ( 24 ) have reported the total ADH activity and class I ADH isoenzymes was significantly higher in women with ICP than in healthy pregnant, indicating that the activity of class I ADH isoenzymes may have a diagnostic significance. However, there are few studies on biomarkers for simultaneous diagnosis and prediction of ICP.…”
Section: Discussionmentioning
confidence: 99%