2011
DOI: 10.1016/j.brainres.2011.07.026
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The alterations of oligodendrocyte, myelin in corpus callosum, and cognitive dysfunction following chronic cerebral ischemia in rats

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Cited by 39 publications
(34 citation statements)
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“…The expression level of myelin basic protein, which is a major component of myelins, is also decreased. 24 On the contrary, the number of OPCs is temporarily increased, but at later time point, OPCs seem to be injured as well. 24 Moreover, this model also shows an increase in matrix metalloproteinases (MMPs) and associate with disruption of BBB, 25 which are similar characteristics observed in clinic.…”
Section: Experimental Models For Subcortical Ischemic Vascular Diseasmentioning
confidence: 99%
See 1 more Smart Citation
“…The expression level of myelin basic protein, which is a major component of myelins, is also decreased. 24 On the contrary, the number of OPCs is temporarily increased, but at later time point, OPCs seem to be injured as well. 24 Moreover, this model also shows an increase in matrix metalloproteinases (MMPs) and associate with disruption of BBB, 25 which are similar characteristics observed in clinic.…”
Section: Experimental Models For Subcortical Ischemic Vascular Diseasmentioning
confidence: 99%
“…24 On the contrary, the number of OPCs is temporarily increased, but at later time point, OPCs seem to be injured as well. 24 Moreover, this model also shows an increase in matrix metalloproteinases (MMPs) and associate with disruption of BBB, 25 which are similar characteristics observed in clinic. Although this model is technically easy to perform and the pathologic changes are well validated, there is at least one potential drawback.…”
Section: Experimental Models For Subcortical Ischemic Vascular Diseasmentioning
confidence: 99%
“…This finding is with agreement of Chen et al study, who found that the consequences of the ischaemia on cerebral white matter are time sensitive, however there was no typical scenario over the time. Chida et al [30] investigated the alterations in oligodendrocytes and myelin following chronic cerebral ischaemia in rats and observed that the amount of MBP was decreased significantly. Cai et al [31] demonstrated a rat model of chronic cerebral hypoperfusion.…”
Section: Discussionmentioning
confidence: 99%
“…MBP is nervous tissue specific, and this protein may reflect the severity of myelin and central nervous system damage [15]. MBP was described as marker of brain injury in neurological conditions, such as cerebral ischaemia, traumatic brain injury, and multiple sclerosis [16][17][18][19].…”
Section: Introductionmentioning
confidence: 99%
“…Although the frank loss of neurons and glia in the infarct core is permanent, the long-term neurological impairment may be mediated partially by loss of myelin function in nonnecrotic central nervous system tissue. 2,3 Significant white matter involvement occurs in the majority of strokes 4 and has been linked to poorer long-term functional outcomes. 5,6 Additionally, oligodendrocytes have been shown to be particularly sensitive to ischemic insult.…”
mentioning
confidence: 99%