The alternating current polarographic behavior and determination of lansoprazole and omeprazole in dosage forms and biological fluids

El‐Enany, N.; Belal, F.; Rizk, Mohamed

doi:10.1016/j.jprot.2008.02.002

Cited by 31 publications

(13 citation statements)

References 20 publications

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“…The slope of the dotted line shows that the same number of electrons and protons is involved in the reduction mechanism of OMZ. The width at half-height of P3 was W 1/2 % 72 mV, which confirms that the reduction of OMZ involves the sulfoxide group [2], and occurs with one-electron and one-proton transfer.…”

Section: Differential Pulse Voltammetrysupporting

confidence: 55%

“…The electrochemical reduction of OMZ using by polarographic techniques [2, 17 -21], and alternating current (AC t ) polarography was studied [2]. The pathway for the electrode reaction involved reduction of the sulfonyl group to the corresponding thiol group at the dropping mercury electrode (DME).…”

Section: Omeprazole (Omz) 5-methoxy-2-[[(4-methoxy-35-dimethyl-2-pymentioning

confidence: 99%

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Electrochemical Redox Behavior of Omeprazole Using a Glassy Carbon Electrode

2010

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The electrochemical redox behavior of omeprazole (OMZ), a gastric acid pump inhibitor, was investigated at a glassy carbon electrode using cyclic, differential pulse and square-wave voltammetry over a wide pH range. The pHdependent oxidation occurs in two irreversible consecutive charge transfer reactions. Adsorption of the nonelectroactive product was also observed. The first oxidation involves removal of one electron, followed by deprotonation and leads to the formation of a hydroxylated species. The second oxidation process is related to the hydroxyl and amino groups in the benzimidazole moiety. The reduction is irreversible, also pH-dependent, and occurs in a single step at the sulfoxide group in a diffusion-controlled mechanism. The diffusion coefficient of omeprazole was calculated to be D OMZ ¼ 2.31 Â 10 À6 cm 2 s À1 .

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Section: Differential Pulse Voltammetrysupporting

confidence: 55%

Section: Omeprazole (Omz) 5-methoxy-2-[[(4-methoxy-35-dimethyl-2-pymentioning

confidence: 99%

Electrochemical Redox Behavior of Omeprazole Using a Glassy Carbon Electrode

2010

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“…For pantoprazole, detection limit and sensitivity were 0.2 μM, 39.2 nA μM −1 cm −2 and concentration range was up to 180 μM. These analytical parameters are comparable and even better than those obtained by using other modified electrodes [26][27][28][29][30][31][32][33]. Figure 6e shows the amperometric response of 40 μM omeprazole during prolonged 500-s experiment.…”

Section: Resultsmentioning

confidence: 62%

“…As a result, they have been used for determination of a wide range of pharmaceutical formulations. The reduction process and quantitative determination of omeprazole and lansoprazole have been investigated by several polarographic techniques [26][27][28][29]. Differential pulse voltammetry and cyclic voltammetry at mercury, carbon paste, and glassy carbon electrodes were used for the determination of lansoprazole, pantoprazole, and omeprazole in pharmaceutical formulations [30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Sensitive amperometric detection of omeprazole and pantoperazole at electrodeposited nickel oxide nanoparticles modified glassy carbon electrode

Salimi

Enferadi

Noorbakhash

et al. 2011

J Solid State Electrochem

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Glassy carbon electrode modified with electrodeposited nickel oxide nanoparticles (NiOxNPs) was used as electrocatalyst for oxidation of omeprazole and pentoperazole in alkaline solution. The modified electrode exhibited efficient electrocatalytic activity for the oxidation of omeprazole and pentoperazole with relatively high sensitivity, excellent stability, and long lifetime. Hydrodynamic amperometric method is used for determination of selected analytes. Under optimized condition, the linear concentration range, detection limit, and sensitivity of modified electrode toward omeprazole detection are 4.5-120 μM, 0.4 μM (at signal to noise 3), and 40.1 nA μM −1 cm −2 , respectively. For pantoperazole, hydrodynamic amperometric determination yielded calibration curve with linear range of 2.5-180 μM, detection limit of 0.2 μM, and sensitivity of 39.2 nA μM −1 cm −2 , respectively. The proposed method was successfully applied to pentoperazole and omeprazole determination in drug samples.

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“…These methods included titrimetry [3][4][5], spectrophotometry [6][7][8],spectrofluorimetry [9], electrochemical [10,11], polarography [12], high performance liquid chromatography (HPLC) with several detection techniques [13][14][15][16][17], thin layer chromatography (TLC) and high performance thin layer chromatography (HPTLC) [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Clarithromycin, Tinidazole and Omeprazole in Helicure Tablets Using Reflectance Near-Infrared Spectroscopy with the Aid of Chemometry

Salam¹

2015

Pharm Anal Acta

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A near infrared spectroscopic method for the simultaneous determination of the active principles clarithromycin, tinidazole and omeprazole in a pharmaceutical preparation was developed. The three active principles are quantified using partial least-squares regression methods. The proposed method is applicable over a wide analyte concentration range (80-120%) of labeled content, so it requires careful selection of the calibration set and to ensure thorough homogenization of the product. The method was validated in accordance with the ICH standard validation guidelines for NIR spectroscopy by determining its selectivity, linearity, accuracy, precision and stability. Based on the results, it is an effective alternative to the existing choice (HPLC) for the same purpose.

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The alternating current polarographic behavior and determination of lansoprazole and omeprazole in dosage forms and biological fluids

Cited by 31 publications

References 20 publications

Electrochemical Redox Behavior of Omeprazole Using a Glassy Carbon Electrode

Electrochemical Redox Behavior of Omeprazole Using a Glassy Carbon Electrode

Sensitive amperometric detection of omeprazole and pantoperazole at electrodeposited nickel oxide nanoparticles modified glassy carbon electrode

Simultaneous Determination of Clarithromycin, Tinidazole and Omeprazole in Helicure Tablets Using Reflectance Near-Infrared Spectroscopy with the Aid of Chemometry

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