The amazing brain

Dikranian, Krikor

doi:10.14748/bmr.v26.1538

Cited by 1 publication

(2 citation statements)

References 24 publications

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“…10 Other key moments of this paradigm shift are marked by the discovery and description of the fi rst neurons in 1837 by the Czech anatomist and physiologist Jan Purkinje (1787-1869) in the cortex of the cerebellum -the trivially named Purkinje cells and the special silver stains developed by Camilo Golgi in 1873 and Santiago Ramon y Cajal in 1887 (1852-1934). 11,12 All these discoveries were later used as the foundation for the neuronal doctrine and as counterargument to the now obsolete reticular theory regarding the structure and functionality of the CNS. 11 During the latter half of the 19 th and fi rst couple of decades of the 20 th century the individual fractions of glial cells were described and their functionality established.…”

Section: Cns Paradigm Shift and Cellular Conceptsmentioning

confidence: 99%

“…11,12 All these discoveries were later used as the foundation for the neuronal doctrine and as counterargument to the now obsolete reticular theory regarding the structure and functionality of the CNS. 11 During the latter half of the 19 th and fi rst couple of decades of the 20 th century the individual fractions of glial cells were described and their functionality established. The Hungarian histologist Michael von Lenosec (1863-1937) fi rst described astrocytes in 1893, the Spaniard Pio del Rio Hortega (1882-1945) described oligodendrocytes and microglial cells in 1919, while also postulating the individual functions of the distinct glial fractions into his neuroglial theory, complying and adding to the already dominant neuronal doctrine.…”

Section: Cns Paradigm Shift and Cellular Conceptsmentioning

confidence: 99%

See 1 more Smart Citation

On the Concepts and History of Glioblastoma Multiforme - Morphology, Genetics and Epigenetics

Stoyanov¹,

Dzhenkov²

2018

Folia Medica

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Glioblastoma multiforme (GBM) is a grade IV WHO malignant tumor with astrocytic differentiation. As one of the most common clinically diagnosed central nervous system (CNS) oncological entries, there have been a wide variety of historical reports of the description and evolution of ideas regarding these tumors. The first recorded reports of gliomas were given in British scientific reports, by Berns in 1800 and in 1804 by Abernety, with the first comprehensive histomorphological description being given in 1865 by Rudolf Virchow. In 1926 Percival Bailey and Harvey Cushing gave the base for the modern classification of gliomas. Between 1934 and 1941 the most prolific researcher in glioma research was Hans-Joachim Scherer, who postulated some of the clinico-morphological aspects of GBM. With the introduction of molecular and genetic tests the true multifomity of GBM has been established, with different genotypes bearing the same histomorphological and IHC picture, as well as some of the aspects of gliomagenesis. For a GBM to develop, a specific trigger mutation needs to occur in a GBM stem cell - primary GBM, or a slow aggregation of individual mutations, without a distinct trigger mutation - secondary GBM. Knowledge of GBM has been closely related to general medical knowledge of the CNS since these malignancies were first described more than 200 years ago. Several great leaps have been made in that time, in the footsteps of both CNS and advancements in general medical knowledge.

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