The ambiguous role of sirtuins in head and neck squamous cell carcinoma

Abstract

Oral cancer is one of the most leading cancer responsible for significant morbidity and mortality. The sirtuins (SIRTs) are a family of class III histone deacetylases and are known to regulate a variety of molecular signaling associated with different cancer types including oral malignancies. SIRT1 acts as bifunctional in a variety of cancer. In oral cancer, SIRT1 seems to work as a tumor suppressor. The carcinogenic potential of SIRT1 is also reported in oral cancer, and hence, its role is still ambiguous.SIRT2 is also said to play a dual-faced role in different types of cancers. However, in oral cancer, SIRT2 is not studied and its role remains obscure. SIRT3 expression was positively correlated with oral malignancies. However, studies also showed the anticancer role of SIRT3 in oral cancer. SIRT7 loss was observed in oral cancer cells, while its overexpression caused the suppression of oral cancer cells proliferation, migration, and invasiveness. The role of other SIRTs in oral cancer was studied meagerly or reports not available. To date, only the roles of SIRT1, SIRT3, and SIRT7 have been reported in oral malignancies. Therefore, understanding the regulatory mechanisms employed by sirtuins to modulate oral cancer is important for developing potential anti-cancer therapeutic strategies.

SIRT-1 and CD44 in the saliva of oral squamous cell carcinoma, dysplastic and non-dysplastic oral leukoplakia

“…Devaraj et al reported that both the tumor suppressor role and carcinogenic role of SIRT1 are reported in oral cancer, so its role is still ambiguous. In oral cancer, SIRT2 is not studied enough and so its role remains obscure (Ezhilarasan et al, 2021). There was no statistically significant difference between dysplastic oral leukoplakia, non-dysplastic oral leukoplakia, and control groups; all showed statistically significantly lower SIRT-1 levels than the OSCC group.…”

Effects Of Dentifrices On Discolouration Of Cad Cam Manufactured Temporary Restorative Materials

“…Our team has extensive knowledge and research experience that has translated into high-quality publications [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. Surface wettability has an important role in many biological, chemical and physical processes.…”

Effect of Mouthwashes and Brushing Simulation on the Surface Roughness of a Bulk Filled Composite Resin - An in vitro Study

“…Our team has extensive knowledge and research experience that has translated into high quality publications [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]26,27]. Composite materials can degrade due to any mechanical or chemical factors from the oral environment including the composition of saliva, masticatory stress exerted, toothpaste used, force of brushing, textures of food particles etc [28].…”