The Ameliorating Role of Geraniol Oil on Renal Toxicity Induced by Some Pesticides in Rats

Abstract

The Defensive impact of geraniol (GeoH) against renal oxidative injury and nephrotoxicity induced by betacyfluthrin, (β-Cyf), fipronil(FPN). and their combined effects on the male rats were investigated. Eight categories, each category of male rats were used contain six rats. Category I as control, Category 2 GeOH (100 mg/kg bwt in corn oil). Categories 3, 4 and 5 rats have presented a single daily oral dose of (FPN) fipronil (4.85 mg/kg bwt), (β-Cyf ) beta-Cyfluthrin (19 mg/kg bwt)) and their combination. Categories 6, 7 and 8 rats have presented the same doses as Categories 3, 4 and 5 with GeOH (100 mg/kg) for 28 consecutive days, respectively. Rats which was exposed insecticides compared to control recorded significant decrease in body weight and rise in kidney weight. Treatment rats recorded significant renal function disruption by increase in uric acid and serum creatinine level. Also, insecticide-treated rats revealed renal oxidative damage was spotted in insecticide-treated rats through an increase in kidney lipid peroxidation (LPO) also, kidney appeared the decrease in antioxidant enzymes. Histopathological analysis of the kidney appeared that tubular destruction with multiple vacuolations, hyaline degeneration in glomeruli, and the thick arterial wall, and irregular glomerular lining in treated groups (FPN, β-Cyf, FPN + β-Cyf). In conclusion, the use of Geraniol (GeOH) seemed to be useful to rats, to a great extent by alleviation and decrease the damage sustained by insecticide exposure.