The Amelioration of Cyanide Induced Liver Toxicity with Bentonite Using Wistar Rat as Experimental Model

Abstract

Aim: The objective of this study was to investigate the ameliorating effect of a natural bentonite found in Nigeria on liver enzymes of Wistar rat fed with cyanide from cassava waste water. The enzymes assayed were alkaline Phosphatase (ALP), alanine amino transferase (ALT) and aspartate amino transferase (AST). Materials and Methods: A total of 45 Wistar rats were used. The rats were divided into four groups and a control group. Each group had nine rats including the control. Groups 1, 2, 3, and 4 were given a daily dose of 0.4ml of cassava waste water containing a sub-lethal amount of cyanide (2.16 x 10-3 mg) for three weeks. Groups 2, 3, and 4 were counter administered with 0.2 ml, 0.4 ml, and 0.8 ml of 7% bentonite solution respectively. Administration of bentonite was done simultaneously with the cyanide administration. Serum samples were assayed weekly for ALP, ALT and AST activities.

Enhancing the nutritional quality of fufu with a starter culture

“…Cassava (Manihot esculenta crantz), a staple food crop in Nigeria, a starch-rich root that provides carbohydrates and energy for sub-Saharan Africa's population [1,2,3]. It makes up 85% of the total weight and is highly carbohydrate-rich, and deficient in protein, riboflavin, thiamin, and niacin concentrations [4,5]. Cassava is processed before consumption to detoxify, avoid post-harvest deterioration, reduce toxicity, improve product palatability, preserve and modify [6,7,8,9].…”

Characterization Of Yellow Root Cassava And Food Products: Investigation Of Cyanogenic Glycosides And Pro-Vitamin A

“…The cortex is comprised of three different cells namely; cortical parenchyma, sclerenchyma and phloem cells, with these group of tissues constituting approximately 11 – 20% of the root weight. The edible portion of the root (parenchyma) constitutes an average of 85% of the total weight [3, 4]. It comprises of the xylem vessels which are radially distributed in a matrix of starch containing cells [3, 4].…”

“…The edible portion of the root (parenchyma) constitutes an average of 85% of the total weight [3, 4]. It comprises of the xylem vessels which are radially distributed in a matrix of starch containing cells [3, 4]. Cassava comprises of a considerable amount of vitamin C (25 mg/100g), phosphorous (40 mg/100g), and calcium (50 mg/100g) [27] while the concentration of proteins, riboflavin, thiamin and niacin in cassava is very low making it the one of highest sources of carbohydrates among tuber crops [5].…”