The ameliorative impacts of Moringa oleifera leaf extract against oxidative stress and methotrexate-induced hepato-renal dysfunction

Soliman, Mohamed Mohamed; Aldhahrani, Adil; Alkhedaide, Adel; Nassan, Mohamed A.; Althobaiti, Fayez; Mohamed, Wafaa A.M.

doi:10.1016/j.biopha.2020.110259

Cited by 51 publications

(34 citation statements)

References 47 publications

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“…RNA was extracted from samples of intestinal tissue using the method described by Soliman et al (Soliman et al., 2020). Samples were frozen then homogenized before adding chloroform and centrifuging at 4°C.…”

Section: Methodsmentioning

confidence: 99%

Protective effects of guarana (Paullinia cupana) against methotrexate‐induced intestinal damage in mice

Aldhahrani

2021

Food Science & Nutrition

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This study aimed to examine the effects of guarana (Paullinia cupana) on intestinal damage induced by MTX in mice. Mice were classified into four groups: control, MTX, guarana (Paullinia cupana), and guarana (Paullinia cupana) together with MTX. Total antioxidant capacity together with glutathione, superoxide dismutase, MDA, ALT, AST, myeloperoxidase, total protein and IL‐1β were detected in the serum. Bax and Bcl2 expressions were detected in intestine together with histopathological examination and immunohistochemical examination of caspase‐9. Intoxication with MTX inhibited antioxidant and promoted myeloperoxidase activity in experimental mouse models but pre‐administration of guarana ameliorated this effect by inhibiting IL‐1β. Real‐time quantitative PCR (qRT‐PCR) analysis found that MTX intoxication upregulated BAX expression, causing apoptosis, and downregulated Bcl2 expression. These were also brought under control following guarana pre‐administration. Histological examination of intestine indicated hyperplasia and desquamation of superficial epithelium of villi in the MTX‐administered group, as well as round cell infiltration in the lamina propria. Pre‐administration of guarana protected against these effects. The MTX group showed that caspase‐9 expression was upregulated, increasing immune‐reactivity in comparison to the guarana experimental groups. These combined effects lead to the conclusion that guarana has a preventative or protective effect against MTX‐induced oxidative stress in the intestinal tissue.

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Section: Methodsmentioning

confidence: 99%

Protective effects of guarana (Paullinia cupana) against methotrexate‐induced intestinal damage in mice

Aldhahrani

2021

Food Science & Nutrition

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“…A plethora of in vivo and in vitro studies provide significant evidence on the prophylactic effect against common diseases, including Alzheimer's, atherosclerosis, diabetes, and neoplasms [7]. With respect to its antioxidant properties, an appreciable number of studies have been conducted within the last few years [8][9][10]. Moringa oleifera extract has also been successfully encapsulated using different techniques in various systems, such as electrospun nanofibers [11], microemulsions [12], phytosomes [13], and spray-dried capsules [14].…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Moringa oleifera Extract in Ca-Alginate Chocolate Beads: Physical and Antioxidant Properties

Kaltsa

Alibade

Bozinou

et al. 2021

Journal of Food Quality

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The aim of the present study was to evaluate the physical and antioxidant properties of chocolate alginate beads containing Moringa oleifera leaf extract (MLE) produced with ecofriendly solvent extraction technology (Deep Eutectic Solvents). The concentration of MLE incorporated was 0, 2, 4, and 6% w / w , and hardening time for ionotropic gelation with CaCl2 solution was 2, 8, or 20 min. Freshly prepared beads were evaluated for their geometric (area, perimeter, ferret diameter, circularity, roundness), color (CIE L ∗ , a ∗ , and b ∗ and chroma), and antioxidant properties (total phenolic content and percentage inhibition of DPPH• radical). Increasing the MLE concentration resulted in beads smaller in size and more spherical, whereas hardening time only affected their circularity. MLE concentration had also a profound effect on color and antioxidant properties of the beads. As the concentration of MLE increased, the beads appeared lighter and their chroma increased. The radical scavenging activity was ameliorated by the MLE concentration increase for samples hardened for 8 and 20 min, whereas it was unaffected for those at 2 min. The hardening time on the contrary did not affect the inhibition of DPPH• values, regardless of the amount of extract added.

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“…Moringa oleifera seed and leaf extracts (MLE) have recently drawn attention for food and medicinal applications mainly due to high levels of antioxidants that can act protectively against the oxidative stress of cells (Lalas and Tsaknis, 2002;Karageorgou et al, 2017;Soliman et al, 2020). These include phytochemicals such as glucosinolate, ascorbic acids, carotenoids, phenolic acids and flavonoids (Dhakad et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Fortification of chocolate usingMoringa oleiferaextract encapsulated in microemulsions

Kaltsa

Alibade

Batra

et al. 2021

OCL

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The aim of the present study was to evaluate the physical and antioxidant properties of microemulsions containing Moringa oleifera leaf extract (MLE) produced by the means of a deep eutectic solvent. Selected microemulsions containing MLE were incorporated in chocolate products to enrich them. Their color properties including CIE L*, a*, b* parameters and whitening index (WI) along with DPPH radical scavenging activity were assessed during a period of 8 months. The antioxidant activity of microemulsions depended on the oil phase used, while it was unaffected by the concentration of MLE. Samples prepared with soybean oil as oil phase containing MLE presented the highest radical inhibition percentage (I% = 26.8–27.8%). Coconut microemulsions were finally incorporated at 2 and 4% w/w concentration into chocolate products, as coconut oil is a known cocoa butter substitute. Although the incorporation of MLE microemulsions did not affect the color properties of most of the chocolates, enriched products did not exhibit superior antioxidant activity compared to control samples.

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The ameliorative impacts of Moringa oleifera leaf extract against oxidative stress and methotrexate-induced hepato-renal dysfunction

Cited by 51 publications

References 47 publications

Protective effects of guarana (Paullinia cupana) against methotrexate‐induced intestinal damage in mice

Protective effects of guarana (Paullinia cupana) against methotrexate‐induced intestinal damage in mice

Encapsulation of Moringa oleifera Extract in Ca-Alginate Chocolate Beads: Physical and Antioxidant Properties

Fortification of chocolate usingMoringa oleiferaextract encapsulated in microemulsions

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