The Ameliorative Potential of Saffron Against the Histological and Immunohistochemical Changes in Kidney of Albino Mice Due to Streptozotocin-Induced Diabetes Mellitus

Nassar, Samir A.; Hashim, Amal M.; Al-Shaer, Nahla H.; elsalam, Sahar Mahmoud Abd

doi:10.21608/ejhm.2019.63229

Cited by 4 publications

(5 citation statements)

References 28 publications

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“…Blood glucose levels were reduced in NZWR treated with 50 and 100 mg/kg of SEE compared to pretreatment in the early atherosclerosis group and established atherosclerosis groups. These results are supported by previous findings reporting the hypoglycemic properties of saffron [55][56][57][58]. The secondary metabolites of saffron, such as flavonoids and terpenes, may be responsible for the present finding [59].…”

Section: Plos Onesupporting

confidence: 93%

Safety evaluation of saffron extracts in early and established atherosclerotic New Zealand white rabbits

Abd Rahim,

Mohd Kasim,

Omar

et al. 2024

PLoS ONE

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Previous research has shown that natural medications pose health risks, especially in subjects with comorbidities. This study aimed to evaluate the safety of saffron ethanolic extract (SEE) administration in early and established atherosclerotic rabbits. Rabbits were given a high-cholesterol diet (HCD) for 4 and 8 weeks to induce early and established atherosclerosis respectively, and then they were treated with 50 and 100 mg/kg/day SEE. The body weight of the animals was recorded. Blood samples were collected at baseline, pre-treatment, and post-treatment for hematological studies, lipid profiles, and biochemical profiles. Tissue specimens of the vital organs were subjected to histological examination. The above parameters were significantly altered post-intervention with 4 and 8 weeks of HCD. No significant differences in body weight were observed in all the groups post-treatment with 50 and 100mg/kg of SEE compared to pre-treatment. However, low-density lipoprotein cholesterol, total cholesterol, serum urea, and glucose significantly decreased post-treatment with 50 and 100mg/kg/day SEE compared to pre-treatment in early and established atherosclerosis groups. Hematological parameters that were affected post-intervention with HCD returned to their baseline values post-treatment with 50 and 100mg/kg/day SEE. There was a significant improvement in the vital organs post-treatment with 50 and 100mg/kg SEE. SEE can safely be administered without causing harmful effects on the hematological, biochemical profiles, and vital organs. Notably, SEE exerts hypolipidemic and hypoglycemic effects on atherosclerotic conditions. Further clinical trials are warranted to ensure the safety of saffron administration in patients with atherosclerosis-related diseases.

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Section: Plos Onesupporting

confidence: 93%

Safety evaluation of saffron extracts in early and established atherosclerotic New Zealand white rabbits

Abd Rahim,

Mohd Kasim,

Omar

et al. 2024

PLoS ONE

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“…Pyknotic and karyolytic nuclei were also observed with exfoliated nuclei in the lumens of some tubules, in addition to the presence of lipofuscin pigments. These histopathological findings come in agreement with the results of Nassar et. al.…”

Section: Discussionsupporting

confidence: 93%

Effect of Ethanolic Olive Leaves Extract on the Renal Cortex of Adult Diabetic Male Albino Rats

Abdelhafez

El‐Dahshan

2022

Egyptian Academic Journal of Biological Sciences, B. Zoology

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Background: renal damage is a common problem in diabetes (D); chronic hyperglycemia is associated with dysfunction in a variety of organs including kidneys. Scientific evidence indicates that medicinal plants comprise a lot of hypoglycemic chemical compounds. Aim of the work: this study aimed to assess the potential ameliorating effect of ethanolic olive leaves extract (OLE) on streptozotocin (STZ) induced D in the renal cortex of adult male rats. This assessment was achieved by biochemical, histopathological and histochemical studies. Materials and Methods: thirty adult Wistar male rats were categorized in three separated groups (10 rats in each group); group 1: control group (C), group 2: diabetic rats (D); streptozotocin was injected intraperitoneally at a single dose of 65 mg/kg b. wt. after 15 minutes of a single dose of nicotinamide which was injected intraperitoneally (230 mg/kg b. wt.), group 3: the diabetic rats which were treated with olive leaf extract (D+ OLE) 15 mg/ kg b. wt. by the gastric tube daily, for 30 days. After one month of treatment, creatinine was measured. Furthermore, histopathological and quantitative histological and histochemical studies were performed. Results: STZ induced a highly significant increase in creatinine level and histopathological changes including desquamation of the epithelial, brush border loss, peritubular infiltration, edematous and hemorrhagic areas, congested vessels and lipofuscin pigments. These pathological findings of the kidney cortex of adult male rats have been reduced by olive leaf extract. Conclusion: use of olive leaf extract should be advised to reduce the hyperglycemic damage to a minimum level.

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“…An increase in serum insulin levels and insulin secretion were also obser ved. 5,38,39,[46][47][48]50,69,70 Saffron extract affects lipid profile by reducing the level of total cholesterol, blood triglyceride level, and VLDL. 5,38,47,[69][70][71] Adiponectin and HDL-C are increased and the LDL / HDL ratio decreased overall improvement in lipid profile was observed.…”

Section: Animal Studiesmentioning

confidence: 99%

“…Many studies demonstrated that saffron extract has positive effects such as improving kidney tissue, reducing creatine, BUN (blood urea nitrogen) serum, immunoexpression of xanthine oxidase (XO) activities, glutathione (GSH) contents, and caspase-3. 38,39,44,46 Kakouri et al used crocin isolated from Crocus sativus L to investigate its effects on the pancreatic beta cell of zebrafish. Embryos of zebrafish were exposed to an aqueous solution containing saffron; then, they measured glucose levels of the whole embryos.…”

Section: Animal Studiesmentioning

confidence: 99%

“…Nassar et al 39 Adult male Wistar rats (Weight 225 ± 25 g) divided into 5 groups: normal control group (g1) received normal saline(1 ml) for 21 days and 4 groups injected with STZ (60 mg/kg, ip) received ethanolic extract of saffron stigma extract (SSE) 25 mg/kg (g2) and 100 mg/kg (g3), Normal saline(1 ml) (g4), glibenclamide (0.6 mg/kg) (g5).…”

Section: Clinical Trialsmentioning

confidence: 99%

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A review of the anti-diabetic potential of saffron

Sani

Tajik

Seiiedi

et al. 2022

Nutr Metab Insights

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Diabetes mellitus is one of the most prevalent metabolic disorders that affect people of all genders, ages, and races. Medicinal herbs have gained attention from researchers and have been widely investigated for their antidiabetic potential. Saffron ( Crocus sativus L.) and its main constituents, that is, crocin and crocetin, are natural carotenoid compounds, widely known to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuro-protective effects. An increasing number of experimental, animal and human studies have investigated the effects and mechanism of action of these compounds and their potential therapeutic use in the treatment of diabetes. This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of diabetes mellitus. Moreover, an overview of the proposed underlying mechanisms mediating these effects, the medicinal applications of saffron, and the new findings regarding its effect on diabetes and various cellular and molecular mechanisms of action will be debated.

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The Ameliorative Potential of Saffron Against the Histological and Immunohistochemical Changes in Kidney of Albino Mice Due to Streptozotocin-Induced Diabetes Mellitus

Cited by 4 publications

References 28 publications

Safety evaluation of saffron extracts in early and established atherosclerotic New Zealand white rabbits

Safety evaluation of saffron extracts in early and established atherosclerotic New Zealand white rabbits

Effect of Ethanolic Olive Leaves Extract on the Renal Cortex of Adult Diabetic Male Albino Rats

A review of the anti-diabetic potential of saffron

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