The ameliorative potential of the ethanol extract of the plant Ocimum basilicum on Biomphalaria alexandrina snails exposed to the insecticide Bestacid

Mossalem, Hanan S.; Ibrahim, Amina M.

doi:10.21608/ejabf.2019.26691

Cited by 4 publications

(3 citation statements)

References 27 publications

(30 reference statements)

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“…In the present study, the hemocytes of S. mansoni infected snails (had higher significant increase compared to the treated -infected snail groups with the sublethal concentration (LC 25 ) of miltefosine and artemether as in previous studies ( Mossalem et al, 2013 ; Ibrahim et al, 2018 ; Mossalem & Ibrahim, 2019 ). The decrease in hemocytes count in treated snail groups might be a result from tissue damage in digestive and hermaphrodite glands as they participated in tissue repair ( Esmaeil, 2009 ).…”

Section: Discussionsupporting

confidence: 68%

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Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies

et al. 2020

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SummaryBiomphalaria alexandrina snails have received much attention due to their great medical importance as vectors for transmitting Schistosoma mansoni infection to humans. The main objective of the present work was to assess the efficacy of miltefosin a synthetic molluscicidal drug and artemether a natural molluscicidal drug. The correlation between immunological and histological observations from light and electron microscopy of the hemocytes of B. alexandrina post treatment with both drugs was also evaluated. LC50 and LC90 values were represented by 13.80 ppm and 24.40 ppm for miltefosine and 16.88 ppm and 27.97 ppm for artemether, respectively. The results showed that the treatment of S. mansoni-infected snails and normal snails with sublethal dose of miltefosine (LC25=8.20 ppm) and artemether (LC25=11.04 ppm) induced morphological abnormalities and a significant reduction in hemocytes count.

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Section: Discussionsupporting

confidence: 68%

“…2006 ). Previous experimental studies proved that the parasitic infection induced positive effect upon hemocytes count by increasing their number in the hemolymph of various species of snails ( Barcante et al, 2012 ; Mossalem & Ibrahim, 2019 ; Suwannatraia et al, 2019).…”

Section: Discussionmentioning

confidence: 97%

Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies

et al. 2020

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“…Snails (Phylum Mollusca, Class Gastropoda) have gained great attention due to their role in ecosystems and disease transmission [ 13 ]. Biomphalaria alexandrina (Ehrenberg, 1831) is a common freshwater snail in Egypt [ 14 ]. It is a host for the trematode parasite Schistosoma manosni , which causes human schistosomiasis [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Histopathological, Immunohistochemical, Biochemical, and In Silico Molecular Docking Study of Fungal-Mediated Selenium Oxide Nanoparticles on Biomphalaria alexandrina (Ehrenberg, 1831) Snails

et al. 2023

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Daphnia magna and freshwater snails are used as delicate bioindicators of contaminated aquatic habitats. Due to their distinctive characteristics, selenium oxide nanoparticles (SeONPs) have received interest regarding their possible implications on aquatic environments. The current study attempted to investigate the probable mechanisms of fungal-mediated selenium nanoparticles’ ecotoxicological effects on freshwater Biomphalaria alexandrina snails and Daphnia magna. SeONPs revealed a toxicological impact on D. magna, with a half-lethal concentration (LC50) of 1.62 mg/L after 24 h and 1.08 mg/L after 48 h. Survival, fecundity, and reproductive rate were decreased in B. alexandrina snails exposed to SeONPs. Furthermore, the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were markedly elevated, while albumin and total protein levels decreased. Histopathological damage in the hermaphrodite and digestive glands was detected by light, electron microscopy, and immunohistochemistry studies. The molecular docking study revealed interactions of selenium oxide with the ALT and AST. In conclusion, B. alexandrina snails and D. magna could be employed as bioindicators of selenium nanomaterial pollution in aquatic ecosystems. This study emphasizes the possible ecological effects of releasing SeONPs into aquatic habitats, which could serve as motivation for regulatory organizations to monitor and control the use and disposal of SeONPs in industry.

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Evaluation of the Effects of Papain on Schistosoma mansoni: Miracidial Infection Capacity, Infection Prevalence, Cercarial Shedding and Molecular Changes in Biomphalaria alexandrina

Ibrahim,

Nasr

2024

Acta Parasit.

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Purpose The aim of the present study is to assess the molluscicidal, larvicidal and genotoxicological activities of papain and how it can affect the host-parasite interactions. Methods Toxicity of papain on snails by making series of concentrations to calculate LC50, and then study its larvicide effect on the free larval stages of S. mansoni and infection rate of snails. Results Papain has a molluscicidal activity on adult snails of Biomphalaria alexandrina with a lethal concentration LC50 equals to 43.1 mg/L. In addition, it has activity on miracidia with half Lethal time (LT50) of 16.11 min., and on cercariae with 12.1 min. compared to control ones. The sub lethal concentration LC10 and LC25 (6.9 or 24.1 mg/L, respectively) decreased the survival rate of snails at the first cercarial shedding, the rate of infection, the average total number of cercariae per snail, the shedding period and the life span of snails, while the prepatent period was significantly increased than the control ones. The morphological alterations in cercariae after exposure to papain were occurred where the cercariae lacked motility and some had a dark tail with complete detachment of head and tail. Compared to the control group, the levels of cytochrome oxidase subunit I (COI) and (ND1) genes significantly decreased in snails after exposure to papain. Conclusions Papain could be used as a potential molluscicide for elimination of schistosomiasis and decrease its transmission and deterioration of host-parasite interaction.

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The ameliorative potential of the ethanol extract of the plant Ocimum basilicum on Biomphalaria alexandrina snails exposed to the insecticide Bestacid

Cited by 4 publications

References 27 publications

Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies

Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies

Histopathological, Immunohistochemical, Biochemical, and In Silico Molecular Docking Study of Fungal-Mediated Selenium Oxide Nanoparticles on Biomphalaria alexandrina (Ehrenberg, 1831) Snails

Evaluation of the Effects of Papain on Schistosoma mansoni: Miracidial Infection Capacity, Infection Prevalence, Cercarial Shedding and Molecular Changes in Biomphalaria alexandrina

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