The ameliorative role of silymarin on trichloroethylene-induced oxidative stress in male albino rats

Gharib, Ola A.; AbdEllatif, Usama; Abdellah, Nadia M.; Mohammad, Marwa A.

doi:10.5455/oams.301012.or.023

Cited by 2 publications

(3 citation statements)

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“…38 Low-dose radiation (LDR) has been shown to trigger a variety of bioeffects, particularly anti-oxidative ones. 39 In the current study, the CIS-treated group showed a disturbance in the cell redox tone manifested by an increase in MDA as well as a decrease in the antioxidant enzymes CAT and SOD in the liver tissue as compared to their respective controls; these findings are in line with other studies. 40,41 and verify that CIS-induced oxidative stress plays a major role in liver disease.…”

Section: Discussionsupporting

confidence: 92%

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Hepatoprotective effect of ferulic acid and/or low doses of γ-irradiation against cisplatin-induced liver injury in rats

et al. 2022

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The therapeutic efficacy of cisplatin (CIS) is limited owing to its hepatotoxic side effects. The current study aimed to investigate the protective impact of ferulic acid (FA) and low-doses of γ-irradiation (LDR) against CIS-prompted hepatotoxicity in rats. Adult male Swiss albino rats were divided into eight groups: untreated group; FA, LDR, and CIS treated groups; and combinations of one or more of the above treatments. Post-treatment analyses included measuring redox markers like SOD and CAT activity, NO free radical content, and lipid peroxidation in liver tissue. Serum aminotransferase activities were also determined. Additionally, gene transcript levels of liver NF-ҡB-P65, caspase-1, COX-2, and IL-1β were quantified. Moreover, immunohistochemistry for caspase-3 and histopathological examinations were estimated in liver tissue. Our findings revealed increased levels of oxidative stress along with a significant reduction in anti-oxidative responses and a significant increase in serum aminotransferase activities in the CIS-intoxicated group. A similar increase was also observed in COX-2 and IL-1β transcript levels and caspase-3 enzyme activity, besides a decrease in transcript levels of NF-ҡB-p65 and caspase-1, indicating an overall inflammatory trend and an increase in the apoptotic shift. The co-administration of FA and/or treatment with LDR has ameliorated the hepatotoxic effect induced by CIS. The histopathological investigation of liver tissues confirmed this ameliorating action of these adjuvant therapies against CIS toxicity. In conclusion, it is plausible to suggest that the hepatoprotective effects of co-administration of FA and/or LDR against CIS-induced hepatotoxicity are attributed to the possession of anti-oxidative, anti-inflammatory, and anti-apoptotic capabilities.

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Section: Discussionsupporting

confidence: 92%

“…38 Low-dose radiation (LDR) has been shown to trigger a variety of bio-effects, particularly anti-oxidative ones. 39…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of ferulic acid and/or low doses of γ-irradiation against cisplatin-induced liver injury in rats

et al. 2022

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“…Increasing evidences indicated that TCE induced oxidative stress to rat kidney tissue and alter their metabolic functions ( 5 , 8 , 10 - 14 ). Numerous studies have shown that antioxidant agents can protect kidney against TCE-induced toxicity ( 10 , 12 - 14 ). Siddiqi et al reported that pretreatment with hesperidin as an antioxidant agent considerably reduced lipid peroxidation, elevation of oxidative enzymes level, blood urea and Cr concentrations in rats exposed to TCE.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effect of vitamin E on trichloroethylene-induced nephrotoxicity in rats

Heydari¹,

Ahmadizadeh²,

Angali³

2016

J Nephropathol

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Background: 1,1,2-Trichloroethylene (TCE) is an important organic solvent which is widespread in the environment. Work place exposure to TCE has been associated adverse effects in many organs including kidney. Vitamin E is an antioxidant that can overcome oxidative stress. Objectives: The aim of the present study is to examine the role of vitamin E against destructive effects of TCE on rat kidney. Materials and Methods: A total of 35 male Wistar rats were randomly divided into seven groups of equal number in each. The rats in group I were the controls received vehicle only. Animals in groups III, V and VII received intraperitoneal injection (i.p) of corn oil. Rats in groups of II, IV, and VI were received vitamin E at a dose of 200 mg/kg; 30 minutes later, animals were received TCE (i.p) at doses of 1000 mg/kg (groups II and III), 1500 mg/kg (groups of IV and V), and 2000 mg/kg (groups of VI and VII) respectively. The experiment repeated for 7 consecutive days. Twenty-four hours after last administration, animals were killed with overdose of sodium pentobarbital. Blood samples were analyzed for blood urea nitrogen (BUN) and creatinine (Cr). One part of the kidney tissues were excised for measuring malondialdehyde (MDA) and glutathione (GSH) concentrations. Another part were excised for histopathological estimation. Results: TCE induced a dose-dependent elevation in BUN, Cr, MDA and markedly decreased GSH level when compared to those in control rats. TCE-induced dose-dependent injury in rat kidney tissue. Vitamin E significantly decreased BUN, Cr, MDA and increased GSH levels and protected kidney damage in TCE treated animals. Conclusions: The observations suggest that vitamin E may have a protective effect against TCE-induced oxidative stress in the rat kidney.

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The ameliorative role of silymarin on trichloroethylene-induced oxidative stress in male albino rats

Cited by 2 publications

References 0 publications

Hepatoprotective effect of ferulic acid and/or low doses of γ-irradiation against cisplatin-induced liver injury in rats

Hepatoprotective effect of ferulic acid and/or low doses of γ-irradiation against cisplatin-induced liver injury in rats

Ameliorative effect of vitamin E on trichloroethylene-induced nephrotoxicity in rats

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