The American Brachytherapy Society consensus guidelines for plaque brachytherapy of uveal melanoma and retinoblastoma

Simpson, E. Rand; Gallie, Brenda L.; Laperrierre, Normand; Beiki-Ardakani, Akbar; Kivelä, Tero; Raivio, Virpi; Heikkonen, Jorma; Desjardins, Laurence; Dendale, R.; Mazal, A.; Bornfeld, Norbert; Sauerwein, W.; Fluehs, D.; Brualla, L.; Honavar, Santosh G; Reddy, Vijay Anand P.; Suzuki, Shigenobu; Murakami, Naoya; Saakyan, S.V.; Valskiy, V.V.; Amiryan, A.G.; Seregard, Stefan; All-Eriksson, Charlotta; Hjelmqvist, Lars; Lundell, G. E. F.; Sinclair, Georges; Lundell, Marie; Damato, Bertil; Errington, R.D.; Mayles, Philip; Mayles, Helen; Bergstrom, Chris S.; Grossniklaus, Hans E.; Crocker, Ian; Butker, Elizabeth; Wilson, Matthew W.; Haik, Barrett G.; Geischen, Holger; Patra, Pradeep Kumar; Duker, Jay S.; Mignano, John E.; Rivard, Mark J.; Finger, Paul T.; Semenova, Ekaterina A.; Choi, Walter; Kalach, Nina

doi:10.1016/j.brachy.2013.11.008

Cited by 293 publications

(186 citation statements)

References 116 publications

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“…Preliminary experiences of episcleral brachytherapy used the high-energy isotope, cobalt-60 ( 60 Co) (37). Currently, iodine-125 ( 125 I) is the most commonly used isotope, but other low-energy isotopes, such as iridium-192, cesium-131, protactinium-103, and ruthenium-106/rhodium-106, have also been used (ABS-OOTF 2014) (38). The Collaborative Ocular Melanoma Study established the role of plaque brachytherapy in the management of ocular melanoma (39).…”

Section: Definitive Rt For Ocular Melanomasmentioning

confidence: 99%

Radiation Therapy for Melanoma

Shi

2017

Cutaneous Melanoma: Etiology and Therapy

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Although melanoma is a relative radioresistant tumor, radiation therapy (RT) remains a valid and effective treatment option for the management of melanoma. RT as a primary treatment is often offered in well-defined situations, such as medical inoperability, lentiginous melanoma, mucosal melanoma, and ocular melanoma. Adjuvant RT following lymphadenectomy in node-positive melanoma patients prevents local and regional recurrence; however, the role of adjuvant RT remains controversial and underutilized due to lack of overall survival benefit. On the other hand, RT is highly effective in providing symptom palliation for metastatic melanoma and is widely used. Advanced RT technologies such as stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT) can achieve excellent local control with minimum toxicities. They are commonly used in the management of brain, lung, spine, and liver metastases. Most recently, it is under active investigation on combining RT with new systemic options, such as targeted therapy, or immunotherapy. The advancements in the treatment of patients with melanoma highlight the importance of multidisciplinary management in this disease. Radiation therapy will continue to be one of the key therapeutic options.

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Section: Definitive Rt For Ocular Melanomasmentioning

confidence: 99%

Radiation Therapy for Melanoma

Shi

2017

Cutaneous Melanoma: Etiology and Therapy

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“…These kinds of tumors have the highest rate of metastasis of any intraocular cancer. The method of treatment is determined according to the type of the cancer and the rate of its progress 1 , 2 , 3 , 4 , 5 . Enucleation, local resection, and radiation therapy are the most common methods of treatment for ocular melanoma (6) .…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticle‐based brachytherapy enhancement in choroidal melanoma using a full Monte Carlo model of the human eye

Asadi

Vaezzadeh

Masoudi

et al. 2015

J Applied Clin Med Phys

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The effects of gold nanoparticles (GNPs) in 125I brachytherapy dose enhancement on choroidal melanoma are examined using the Monte Carlo simulation technique. Usually, Monte Carlo ophthalmic brachytherapy dosimetry is performed in a water phantom. However, here, the compositions of human eye have been considered instead of water. Both human eye and water phantoms have been simulated with MCNP5 code. These simulations were performed for a fully loaded 16 mm COMS eye plaque containing 13 125I seeds. The dose delivered to the tumor and normal tissues have been calculated in both phantoms with and without GNPs. Normally, the radiation therapy of cancer patients is designed to deliver a required dose to the tumor while sparing the surrounding normal tissues. However, as the normal and cancerous cells absorbed dose in an almost identical fashion, the normal tissue absorbed radiation dose during the treatment time. The use of GNPs in combination with radiotherapy in the treatment of tumor decreases the absorbed dose by normal tissues. The results indicate that the dose to the tumor in an eyeball implanted with COMS plaque increases with increasing GNPs concentration inside the target. Therefore, the required irradiation time for the tumors in the eye is decreased by adding the GNPs prior to treatment. As a result, the dose to normal tissues decreases when the irradiation time is reduced. Furthermore, a comparison between the simulated data in an eye phantom made of water and eye phantom made of human eye composition, in the presence of GNPs, shows the significance of utilizing the composition of eye in ophthalmic brachytherapy dosimetry Also, defining the eye composition instead of water leads to more accurate calculations of GNPs radiation effects in ophthalmic brachytherapy dosimetry.PACS number: 87.53.Jw, 87.85.Rs, 87.10.Rt

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“…Brachytherapy with radioactive ophthalmic applicators is an effective treatment modality for tumours of the eye [1,2]. These plaques emit either β radiation or low-energy photons, and the resulting radiation fields are characterized by steep dose fall-offs within a few millimetres.…”

Section: Introductionmentioning

confidence: 99%

Polyethylene Naphthalate Scintillator: A Novel Detector for the Dosimetry of Radioactive Ophthalmic Applicators

Flühs¹,

Flühs²,

Ebenau³

et al. 2015

Ocul Oncol Pathol

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Background: Dosimetric measurements in small radiation fields with large gradients, such as eye plaque dosimetry with β or low-energy photon emitters, require dosimetrically almost water-equivalent detectors with volumes of <1 mm³ and linear responses over several orders of magnitude. Polyvinyltoluene-based scintillators fulfil these conditions. Hence, they are a standard for such applications. However, they show disadvantages with regard to certain material properties and their dosimetric behaviour towards low-energy photons. Purpose, Materials and Methods: Polyethylene naphthalate, recently recognized as a scintillator, offers chemical, physical and basic dosimetric properties superior to polyvinyltoluene. Its general applicability as a clinical dosimeter, however, has not been shown yet. To prove this applicability, extensive measurements at several clinical photon and electron radiation sources, ranging from ophthalmic plaques to a linear accelerator, were performed. Results: For all radiation qualities under investigation, covering a wide range of dose rates, a linearity of the detector response to the dose was shown. Conclusion: Polyethylene naphthalate proved to be a suitable detector material for the dosimetry of ophthalmic plaques, including low-energy photon emitters and other small radiation fields. Due to superior properties, it has the potential to replace polyvinyltoluene as the standard scintillator for such applications.

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The American Brachytherapy Society consensus guidelines for plaque brachytherapy of uveal melanoma and retinoblastoma

Abstract: Plaque brachytherapy is an effective eye and vision-sparing method to treat patients with intraocular tumors. Practitioners are encouraged to use ABS-OOTF guidelines to enhance their practice.

Cited by 293 publications

References 116 publications

Radiation Therapy for Melanoma

Radiation Therapy for Melanoma

Gold nanoparticle‐based brachytherapy enhancement in choroidal melanoma using a full Monte Carlo model of the human eye

Polyethylene Naphthalate Scintillator: A Novel Detector for the Dosimetry of Radioactive Ophthalmic Applicators

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