The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM

Edge, Stephen B.; Compton, Carolyn C.

doi:10.1245/s10434-010-0985-4

Cited by 8,188 publications

(6,876 citation statements)

References 1 publication

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“…At baseline, deceased patients had a lower body mass index (24 kg/m 2 vs. 25 kg/m 2 , P = 0.026) and had lost more body weight (5.4% vs. 2.4%, P = 0.019) than alive patients. Moreover, deceased patients had more severe anorexia (SNAQ score: deceased vs. alive patients: 146, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 vs. 168, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20; P = 0.005), more symptoms (QLQ‐C30: deceased vs. alive patients: 33 2–66 vs. 15 6–69 ; P < 0.0001), a poorer quality of life (QLQ‐C30: deceased vs. alive patients: 58 16–100 vs. 66 0–100 ; P = 0.002) and a lower functional capacity (QLQ‐C30: deceased vs. alive patients: 64 18–97 vs. 82 33–100 ; P < 0.0001 and ECOG; P < 0.0001) than alive patients.…”

Section: Resultsmentioning

confidence: 99%

Circulating Activin A predicts survival in cancer patients

Loumaye

Barsy

Nachit

et al. 2017

J cachexia sarcopenia muscle

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BackgroundSeveral experimental evidences pinpoint the possible role of Activin A (ActA) as a driver of cancer cachexia. Supporting this hypothesis, we showed recently that human cancer cachexia is associated with high ActA levels. Moreover, ActA levels were correlated with body weight loss and skeletal muscle density, two prognostic factors in cancer patients. Our goal was therefore to investigate the value of ActA to predict survival in cancer patients.MethodsPatients with colorectal or lung cancer were prospectively enrolled at the time of diagnosis or relapse between January 2012 and March 2014. At baseline, patients had clinical, nutritional, and functional assessment. Body composition and skeletal muscle density were measured by CT scan, and plasma ActA concentrations were determined. Overall survival (OS) was analysed since inclusion to 24 months later.ResultsSurvival data were available for 149 patients out of 152. Patients with high ActA (≥408 pg/mL) had lower OS than those with low levels, regardless the type of cancer (OS in colorectal cancer, 50% vs. 79%, P < 0.05; and in lung cancer, 27% vs. 67%, P = 0.001). The multivariable analysis confirmed the prognostic value of ActA independently of tumour stage or inflammatory markers, particularly in lung cancer. Low muscularity was also an independent prognostic factor.ConclusionsOur study demonstrates that high ActA level is an independent prognosis factor of survival in cancer patients. More than a basic marker of the severity of the neoplastic disease or of the inflammatory process, ActA seems to influence survival by contributing to the development of cachexia and loss of skeletal muscle mass.

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Section: Resultsmentioning

confidence: 99%

Circulating Activin A predicts survival in cancer patients

Loumaye

Barsy

Nachit

et al. 2017

J cachexia sarcopenia muscle

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“…Age is considered to be the most important prognostic factor as demonstrated by the majority of current risk stratification systems. To the best of our knowledge, TNM classification is the only staging system that adopts 45‐year as the cut‐off value for age to stratify the patients in high‐ and low‐risk groups for cancer‐specific mortality 16, 17. The fact that the widowed group has the highest proportion of elderly patients (≥45 years) and greatest overall mean age becomes one hypothesis to explain the influence of marital status on prognosis in DTC.…”

Section: Discussionmentioning

confidence: 99%

“…We followed the guidance of the 2010 TNM classification of American Joint Committee on Cancer/International Union Against Cancer 15, 16, 17. The endpoint of present study was CSS which was calculated from the date of diagnosis to the date of cancer‐specific death and was shown as “SEER cause‐specific survival” in SEER database.…”

Section: Methodsmentioning

confidence: 99%

The impact of marital status at diagnosis on cancer survival in patients with differentiated thyroid cancer

Shi

Lü

et al. 2016

Cancer Medicine

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Previous studies have revealed that marital status influences the prognosis of patients with various types of cancer. We evaluated the influence of marriage on the survival outcomes in differentiated thyroid cancer (DTC). The Surveillance, Epidemiology and End Results (SEER) database between 2002 and 2012 was used to compare cancer‐specific mortality in different marital status, and in each sex, age, and stage stratification by multivariate Cox regression model. In total, 61,077 eligible patients were identified. The widowed group had the highest proportion of women, elderly patients (≥45 years), and advanced stage III/IV tumor (P = 0.001), but the total thyroidectomy (TT) performed and radioisotopes therapy rates were lower than those in the married group. Married patients had a better cancer‐specific survival (CSS) than the unmarried (P < 0.05). Further analysis showed that widowed patients always presented the lowest CSS compared with other groups. Widowed patients had a significant increased risk for CSS compared with married patients in males [hazard ratio (HR) 2.72, 95% confidence interval (CI): 1.59–4.65, P = 0.001], females (HR 2.02, 95% CI: 2.24–4.06, P = 0.001), young patients (<45, HR 28.12, 95% CI: 3.48–227.25, P = 0.002), elderly patients (≥45, HR 28.12, 95% CI: 2.97, 95% CI: 2.30–3.83, P = 0.001), stage I (HR 8.44, 95% CI: 4.05–17.59, P = 0.001), stage II (HR 3.64, 95% CI: 1.30–10.20, P = 0.014), stage III (HR 2.27, 95% CI: 1.08–4.78, P = 0.031), and stage IV (HR 2.63, 95% CI: 1.94–3.57, P = 0.001). These results showed that unmarried status, especially for widowhood, increased the risk of cancer mortality in DTC patients.

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“…Although the total incidence of colon cancer continues to decline, its incidence in individuals younger than the age of 50 has steadily increased at around 2% per year from 1993 to 2013 [1]. According to the American Joint Committee on Cancer 2010, colon cancer is classified into four stages based on the degree of colonic wall infiltration, lymph node involvement, and distant metastasis [2]. The standard of care for node-positive colon cancer without distant metastasis (Stage III) is surgery followed by 12 cycles of adjuvant oxaliplatin with fluorouracil (5FU) and folinic acid (FOLFOX chemotherapy).…”

Section: Introductionmentioning

confidence: 99%

Factors associated with short recurrence-free survival in completely resected colon cancer

Alnimer

Ghamrawi

Aburahma

et al. 2017

Journal of Community Hospital Internal Medicine Perspectives

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Background: Several factors could affect disease recurrence in surgically resected colon cancer. While the role of certain factors such as cancer stage and grade is well established, the role of other factors (e.g., histological subtypes) is yet to be determined. Objective:Therefore, we conducted a study to evaluate the impact of several factors in recurrence-free survival (RFS) in patients who were disease free following surgical resection of the colon cancer. Design/Methods: Data were collected for patients with Stage I–III colon cancer who underwent complete surgical resection of the tumor between January 2010 and December 2015 in our institution. A total of 90 subjects met the inclusion criteria and were included in the study. The following factors were collected at the time of surgical resection of the colonic tumor: patient’s age, gender, colon cancer stage, grade and histological subtype, body mass index, hemoglobin A1c, and smoking history. Results: A total of 28 patients (31%) developed recurrence and had a mean follow-up time of 19.8 months (range: 2–54.4 months). Median RFS was 54.4 months with a 5-year RFS of 49%. Advanced colonic cancer stage and mucinous histological subtype were associated with shorter RFS with an HR of 2.37, 95% CI = 1.38–4.06, and 95% CI = 1.02–5.90, respectively. Current smokers or those who quit less than 15 years earlier tended to have worse RFS with an HR of 2.47, 95% CI = 0.98–6.27. Conclusion: Advanced colon cancer stage and mucinous histological subtype are independent risk factors for cancer recurrence and shorter RFS in completely resected colonic tumor.

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The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM

Cited by 8,188 publications

References 1 publication

Circulating Activin A predicts survival in cancer patients

Circulating Activin A predicts survival in cancer patients

The impact of marital status at diagnosis on cancer survival in patients with differentiated thyroid cancer

Factors associated with short recurrence-free survival in completely resected colon cancer

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