The American Red Cross donor hemovigilance program: complications of blood donation reported in 2006

Eder, Anne F.; Dy, Beth A.; Kennedy, Jean M.; Notari, Edward P.; Strupp, Annie; Wissel, Mary Ellen; Reddy, Ramakrishna; Gibble, Joan; Haimowitz, Marcia D.; Newman, Bruce; Chambers, Linda A.; Hillyer, Christopher D.; Benjamin, Richard J.

doi:10.1111/j.1537-2995.2008.01811.x

Cited by 148 publications

(205 citation statements)

References 16 publications

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“…The high risk groups for VVRs are generally reported to be young, female, first-time donors [2,18,[25][26][27]. In our analysis, female gender was a significant risk factor in the univariate analysis in group I; however, it was not significant in the multivariate analysis in both group I and the overall group.…”

Section: Discussioncontrasting

confidence: 48%

“…The additional analysis that included more patients (the overall group) revealed that lower systolic blood pressure was the strongest independent predictor of VVR (OR = 2.45 (95% CI = 1.50-4.01), p < 0.001)). Our data add evidence that patients with a lower blood pressure are more susceptible to VVRs.The high risk groups for VVRs are generally reported to be young, female, first-time donors [2,18,[25][26][27]. In our analysis, female gender was a significant risk factor in the univariate analysis in group I; however, it was not significant in the multivariate analysis in both group I and the overall group.…”

contrasting

confidence: 48%

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Predictors of vasovagal reactions during preoperative autologous blood donation: a single-institution analysis

Nishimori

Fujii

et al. 2017

Int J Hematol

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Studies examining risk factors associated with vasovagal reactions (VVRs) during autologous blood donations, especially in younger subjects, have been limited. The aim of the present study was to define risk factors for VVRs during preoperative autologous blood donation in patients, including those younger than 18 years old. We retrospectively analyzed 4,192 autologous, preoperative blood donations between 2007 and 2015 at Okayama University Hospital. Eighty-seven (2.08%) of the patients experienced VVRs. VVRs occurred approximately three times as often in patients 0-17 years old (16/320, 5.0%) than in patients 18 years and older (71/3,872, 1.8%). In particular, VVRs occurred more frequently in those 10-13 years old, and decreased with older age (P = 0.006). In a univariate analysis, younger age, lower body mass index, lower systolic blood pressure, lower body weight, lower total blood volume, female gender, first-time collection, and higher heart rate were associated with a higher incidence of VVRs. In a multivariate analysis, lower systolic blood pressure (P < 0.001), higher heart rate (P = 0.007), and first-time collection (P = 0.015), remained independent predictors of VVRs. These results emphasize the need for careful attention during blood collection. Keywords: Autologous blood donation, vasovagal reactions 3 IntroducitonAutologous blood donation is widely used for preoperative blood preparation to reduce exposure to allogeneic blood [1]. Autologous and allogeneic blood donors occasionally experience adverse reactions during or after blood withdrawal, such as weakness, pallor, nausea, sweating, and fainting [2,3]. These symptoms are generally called "vasovagal reactions" (VVRs) [2,4]. However, the pathophysiology of VVRs is not yet completely understood [5]. Although risk factors for VVRs have been analyzed mainly in healthy allogeneic donors or peripheral blood stem cell donors [2,4,[6][7][8], reports describing patients undergoing autologous collection have been limited. In particular, there are few data concerning patients younger than 16-18 years old. In the present study, we analyzed the risk factors for VVRs during autologous donation in patients, including those younger than 18 years old, at a single institution. Materials and methodsWe retrospectively collected medical information from 4,192 patients (groups I + II) who underwent autologous Patients were screened for vital signs, height, body weight, and complete blood count. Enrolled patients underwent whole blood phlebotomy in a designated room: blood volumes did not exceed 400 mL, or [body weight]/50 × 400 mL if the patient's body weight was less than 50 kg. All collections were conducted by a physician and nurse from the Department of Transfusion Medicine at Okayama University Hospital. An 18-gauge needle was inserted into an antecubital vein or a large forearm vein of each patient, and autologous blood was collected using a negative pressure blood drawing device (Hemoquick; Terumo, Tokyo, Japan). After phlebotomy, the patients were adm...

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Section: Discussioncontrasting

confidence: 48%

contrasting

confidence: 48%

Predictors of vasovagal reactions during preoperative autologous blood donation: a single-institution analysis

Nishimori

Fujii

et al. 2017

Int J Hematol

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“…Hemovigilance during blood donation (BD) has been receiving increasing attention [1,2,3,4]. The European Guide to preparation, use and quality assurance of blood components listed adverse reactions related to BDs and included donor safety standards [5].…”

Section: Introductionmentioning

confidence: 99%

Donor Hemovigilance during Preparatory Plasmapheresis

Diekamp¹,

Gneißl²,

Rabe³

et al. 2014

Transfus Med Hemother

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Background: Reports on unexpected donor events (UEs) during preparatory plasmapheresis (PPP) are scarce, and rarely consider technical UEs. Methods: Defined local and systemic UEs were graded by severity; technical UEs were not graded. On January 1, 2008, E.B.P.S.-Logistics (EBPS) installed the UE module for plasma management software (PMS). Donor room physicians entered UEs daily into the PMS. Medical directors reviewed entries quarterly. EBPS compiled data on donors, donations and UEs from January 1, 2008 to June 30, 2011. Results: 66,822 UEs were observed during 1,107,846 PPPs for a corrected incidence of 6.55% (1.4% local, 0.55% systemic, 4.6% technical UEs). 3.36% of PPPs were accompanied by 1 UE and 1.18% by >1 UE (2-5). 13.7% of donors undergoing PPP for the first time, 9.7% of those having a second PPP and 4.0% of those having a third or more PPPs were associated with UEs. Most common UEs were repeated venipuncture, and broken-off collection due to venous access problems and small hematomas. Severe systemic UEs occurred at a rate of 36 per 100,000 PPPs. Conclusions: Technical UEs were common with PPP. UEs accompanied first and second donations significantly more frequently than for subsequent donations.

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“…42 Hematom veya yatay biçimde kan sızıntısının kan bağışı merkezlerinde görülme sıklığı sırasıyla %0,32 ve %1,05'tir. 43,44 Bir çalışmada (n=19,076), lokal reaksiyonlar ile ilgili olarak, en sık görülen yan etkinin %0,07 oranında hematom olduğu tespit edilmiş-tir. 26 Diğer bir çalışmada (n=37896) tüm reaksiyonların %35'ini hematomların oluşturduğu bulunmuştur.…”

Section: Kan Bağişi Nedeni̇yle Geli̇şen Kompli̇kasyonlarunclassified

Complications Developed Due to Blood Donation: Review

İnce¹,

Khorshıd²

2016

Turkiye Klinikleri J Nurs

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53Kan Bağışı Nedeniyle Gelişen Komplikasyonlar Ö ÖZ ZE ET T Hastalar için kan ve kan ürünlerine olan talebin artması, tüm dünyada mücadele etmeyi gerektiren bir duruma yol açmıştır. Kan ihtiyacının karşılanması, sağlık gönüllülerine ve onların sü-rekli olarak kan ve kan ürünlerini verme istekliliğine bağlıdır. Kan bağışı genel olarak güvenli bir yöntem olarak kabul edilir. Ancak, işlem sırası ya da sonrasında şiddeti farklılık gösteren bazı istenmeyen komplikasyonlar görülebilir. Kan bağışı ile ilgili yan etkilerin sıklığı, güvenli ve uygun donörlerin olduğu havuzu azaltmaktadır. Bu da tekrarlı kan bağış oranını düşürmekte ve her geçen gün aralıksız ve sürekli artan kan ihtiyacına ilişkin talebi karşılamakta güçlüğe neden olmaktadır. Kan bağışında bulunanların genç olması, kadın olması, ilk kez kan vermesi, tahmin edilenden daha düşük kan volümüne sahip olması gibi bazı özelliklerinin, daha yüksek komplikasyon sıklığı ile iliş-kili olduğu ortaya konmuştur. Kan bağışı ile ilgili bazı reaksiyonlar ciddi sonuçlara yol açabilirler. Bunlar ekimoz, hematom, arter delinmesi, kol ağrısı, tromboflebit, enfeksiyon riski, sinir yaralanması, kronik bölgesel ağrı sendromu ve vazovagal reaksiyonlardır. Bu komplikasyonlar ve baş dön-mesi, bulantı, baygınlık gibi ilişkili semptomlar, istemli kan vericilerini, gelecekte tekrar kan bağışında bulunmaları için caydırabilir. Hemşireler kan bağışı sırasında gelişebilecek komplikasyonların farkında olmalı ve yüksek risk grubundaki bireyler için gerekli önlemleri almalıdır. Bu makalede, kan bağışı sırasında oluşan komplikasyonların önlenmesine yardım edebilecek uygulamalar sunulmuştur.A An na ah ht ta ar r K Ke el li im me el le er r: : Kan vericiler; komplikasyonlar; hemşirelik A AB BS ST TR RA AC CT T Incrementing request of blood and blood products for patients has caused a status for defiance for the blood banks in all world. Meeting the need for blood products depends on the existence of healthy volunteers and their continued availability to donate blood and blood products. While blood donation is generally accepted as a safe procedure, some adverse complications of variable severity may be observed during or after the operation. Frequent side effects associated with blood donation reduce the pool of safe and reliable donors, sinking the repeat donation rate. This in turn, reduce the blood donation rate, cause to difficulties in meeting the continually increasing demand for blood. Certain characteristics such as the young age and the female sex of the donors, first time donors and smaller estimated blood volume have been shown to be related to the frequency of complication. Some reactions related to blood donation have the potential to lead to serious results. These are, bruise, haematoma, arterial punctures, sore arm, thrombophlebitis, risk of infection, nerve injuries, chronic regional pain syndrome and vasovagal reactions. These complications and related symptoms such as dizziness, nauses and fainting can dissuade volunteer blood donors from returning to donate in the future. N...

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The American Red Cross donor hemovigilance program: complications of blood donation reported in 2006

Cited by 148 publications

References 16 publications

Predictors of vasovagal reactions during preoperative autologous blood donation: a single-institution analysis

Predictors of vasovagal reactions during preoperative autologous blood donation: a single-institution analysis

Donor Hemovigilance during Preparatory Plasmapheresis

Complications Developed Due to Blood Donation: Review

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