The amount and types of fatty acids acutely affect insulin, glycemic and gastrointestinal peptide responses but not satiety in metabolic syndrome subjects

Chang, Chee-Yan; Kanthimathi, M.S.; Tan, Alexander Tong Boon; Nesaretnam, Kalanithi; Teng, Kim-Tiu

doi:10.1007/s00394-016-1307-9

Cited by 12 publications

(11 citation statements)

References 41 publications

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“…1 of [16]). These results could be in agreement with ours although GLP-1 response was very variable depending on the time period after eating [1516]. …”

supporting

confidence: 92%

“…Interestingly, GLP-1 response at early phase (30 minutes) after eating was higher after CHO-rich meal compared with fat-rich meal, and SFA meal caused more GLP-1 response than PUFA meal, but opposite results were observed at late phase (6 hours after eating) (Fig. 2A of [ 15 ]). The early phase response of GLP-1 AUC(0–2 hr) was 27% and 23% higher after CHO-rich meal compared with monounsaturated fatty acid (MUFA) and n-6 PUFA meals, respectively (Fig.…”

mentioning

confidence: 99%

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Response: Regulating Hypothalamus Gene Expression in Food Intake: Dietary Composition or Calorie Density? (Diabetes Metab J2017;41:121-7)

et al. 2017

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“…1 of [16]). These results could be in agreement with ours although GLP-1 response was very variable depending on the time period after eating [1516]. …”

supporting

confidence: 92%

mentioning

confidence: 99%

Response: Regulating Hypothalamus Gene Expression in Food Intake: Dietary Composition or Calorie Density? (Diabetes Metab J2017;41:121-7)

et al. 2017

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“…Several studies have suggested that a high intake of saturated fat naturally present in meat contributes to the risk of glucose intolerance [1,12] due to impaired beta-cell sensitivity and function. Fat quantity and quality have been shown to affect the gastrointestinal peptide release in people with metabolic syndrome [32].…”

Section: Discussionmentioning

confidence: 99%

“…In addition to fat quality, carbohydrate quality needs to be taken into account. The V-meal contained naturally more fiber and less sugar than the M-meal and these differences may have influenced the findings [32].…”

Section: Discussionmentioning

confidence: 99%

A Plant-Based Meal Stimulates Incretin and Insulin Secretion More Than an Energy- and Macronutrient-Matched Standard Meal in Type 2 Diabetes: A Randomized Crossover Study

et al. 2019

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Diminished postprandial secretion of incretins and insulin represents one of the key pathophysiological mechanisms behind type 2 diabetes (T2D). We tested the effects of two energy- and macronutrient-matched meals: A standard meat (M-meal) and a vegan (V-meal) on postprandial incretin and insulin secretion in participants with T2D. A randomized crossover design was used in 20 participants with T2D. Plasma concentrations of glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1), amylin, and gastric inhibitory peptide (GIP) were determined at 0, 30, 60, 120, and 180 min. Beta-cell function was assessed with a mathematical model, using C-peptide deconvolution. Repeated-measures ANOVA was used for statistical analysis. Postprandial plasma glucose responses were similar after both test meals (p = 0.64). An increase in the stimulated secretion of insulin (by 30.5%; 95% CI 21.2 to 40.7%; p < 0.001), C-peptide (by 7.1%; 95% CI 4.1 to 9.9%; p < 0.001), and amylin (by 15.7%; 95% CI 11.8 to 19.7%; p < 0.001) was observed following consumption of the V-meal. An increase in stimulated secretion of GLP-1 (by 19.2%; 95% CI 12.4 to 26.7%; p < 0.001) and a decrease in GIP (by −9.4%; 95% CI −17.3 to −0.7%; p = 0.02) were observed after the V-meal. Several parameters of beta-cell function increased after the V-meal, particularly insulin secretion at a fixed glucose value 5 mmol/L, rate sensitivity, and the potentiation factor. Our results showed an increase in postprandial incretin and insulin secretion, after consumption of a V-meal, suggesting a therapeutic potential of plant-based meals for improving beta-cell function in T2D.

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“…Thus, dietary intervention based on energy restriction, independently of the distribution of macronutrients, might influence BP and CVD. Accordingly, most scientific evidence highlights the relevance of dietary quality rather than quantity, especially in the management and prevention of MetS [ 8 , 145 , 146 , 147 ]. Moreover, the effectiveness of every dietary intervention is associated with the previous metabolic state (e.g., presence of insulin resistance, T2DM, altered fasting glucose levels, etc.)…”

Section: Other Dietary Patterns and Strategiesmentioning

confidence: 99%

Dietary Strategies for Metabolic Syndrome: A Comprehensive Review

et al. 2020

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Metabolic syndrome is a cluster of metabolic risk factors, characterized by abdominal obesity, dyslipidemia, low levels of high-density lipoprotein cholesterol (HDL-c), hypertension, and insulin resistance. Lifestyle modifications, especially dietary habits, are the main therapeutic strategy for the treatment and management of metabolic syndrome, but the most effective dietary pattern for its management has not been established. Specific dietary modifications, such as improving the quality of the foods or changing macronutrient distribution, showed beneficial effects on metabolic syndrome conditions and individual parameters. On comparing low-fat and restricted diets, the scientific evidence supports the use of the Mediterranean Dietary Approaches to Stop Hypertension (DASH) diet intervention as the new paradigm for metabolic syndrome prevention and treatment. The nutritional distribution and quality of these healthy diets allows health professionals to provide easy-to-follow dietary advice without the need for restricted diets. Nonetheless, energy-restricted dietary patterns and improvements in physical activity are crucial to improve the metabolic disturbances observed in metabolic syndrome patients.

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The amount and types of fatty acids acutely affect insulin, glycemic and gastrointestinal peptide responses but not satiety in metabolic syndrome subjects

Abstract: The amount of fat regardless of the types of fatty acids affects insulin and glycemic responses. Both the amount and types of fatty acids acutely affect the gastrointestinal peptide release in metabolic syndrome subjects, but not satiety.

Cited by 12 publications

References 41 publications

Response: Regulating Hypothalamus Gene Expression in Food Intake: Dietary Composition or Calorie Density? (Diabetes Metab J2017;41:121-7)

Response: Regulating Hypothalamus Gene Expression in Food Intake: Dietary Composition or Calorie Density? (Diabetes Metab J2017;41:121-7)

A Plant-Based Meal Stimulates Incretin and Insulin Secretion More Than an Energy- and Macronutrient-Matched Standard Meal in Type 2 Diabetes: A Randomized Crossover Study

Dietary Strategies for Metabolic Syndrome: A Comprehensive Review

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