The Amount of Hemoglobin and the Blood Volume in Relation to the Pulse Rate and Cardiac Volume During Rest

Kjellberg, Sven Roland; Rudhe, Ulf; Sjöstrand, Torgny

doi:10.1111/j.1748-1716.1949.tb00145.x

Cited by 65 publications

(11 citation statements)

References 6 publications

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“…End-diastolic dimension was lower in the females than in the males. This difference may be attributed to the smaller heart size as suggested by our values of left ventricular mass index and as suggested by others (2,16).…”

Section: Discussionmentioning

confidence: 61%

Comparison of Hemodynamic and Left Ventricular Responses to Increased After-Load in Healthy Males and Females

Sagiv

Metrany²,

Fisher³

et al. 1991

Int J Sports Med

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Hemodynamic and left ventricular responses were studied echocardiographically in 20 males (31.5 +/- 4.5 yrs) and 20 females (30.4 +/- 4.3 yrs) at rest and during 3 min of isometric deadlift exercise at 30% of maximum voluntary contraction. Maximal tension exerted was significantly (P less than .001) lower in the female group (87.4 +/- 8.1 kg) compared with the male group (127.3 +/- 15 kg). Significant (P less than .001) increases in heart rate and contractility index were noted in both groups during exercise compared to the resting values. Mean arterial blood pressures were significantly (P less than .05) higher in the males at rest and during exercise. Ejection fraction and fractional shortening, both at rest and during exercise, differed significantly (P less than .05) between the two groups. It was raised by exercise only in the males (from 62 +/- 5% to 65 +/- 5% and 32 +/- 4% to 35 +/- 4%, respectively) but remained unchanged in the females. No significant changes in end diastolic dimension and stroke volume were observed in either group during exercise. End systolic dimension was significantly (P less than .001) lower during exercise in females and males (from 3.25 +/- .23 to 3.1 +/- .26 and 3.12 +/- .33 to 3.00 +/- .32 cm, respectively). These data indicate that hemodynamic and left ventricular function in normal male and female subjects were augmented during submaximal isometric exercise. However, females do so with lower after-load than males.

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Section: Discussionmentioning

confidence: 61%

Comparison of Hemodynamic and Left Ventricular Responses to Increased After-Load in Healthy Males and Females

Sagiv

Metrany²,

Fisher³

et al. 1991

Int J Sports Med

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“…Sjostrand, 1949). In relation to total haemoglobin the heart volumes were all within normal limits (Kjellberg, Rudhe, and Sjostrand, 1949;Holmgren and Ovenfors, 1960).…”

Section: Methodsmentioning

confidence: 79%

Effects remaining after withdrawal of long-term beta-receptor blockade. Reduced heart rate and altered haemodynamic response to acute propranolol administration.

Brundin¹,

Edhag²,

Lundman³

1976

Heart

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Central haemodynamics at rest and during exercise were studied in 14 male patients with moderate essential hypertension. Their circulatory state was studied before and immediately after intravenous administration ofpropranolol, 0.2 mg/kg body weight. In 8 of the patients an identical study was repeated after .2 months of oral propranolol therapy. This second study was performed when the oral therapy had been discontinued for >72 hours which exceeds the time necessary for complete metabolism and excretion of propranolol. Pulmonary oxygen uptake, arteriovenous oxygen difference, heart rate, and blood pressures in the subclavian artery, pulmonary artery, pulmonary wedge position, and right atrium were measured.Before oral treatment, propranolol injection caused significant reductions of oxygen uptake (5%), heart rate ( 13%), cardiac output ( 20%), and stroke volume ( -10%), significant increments to systemic (35/3%) and pulmonary vascular resistance ( -35%)°, and increased filling pressures for both ventricles during exercise. After long-term treatment and omission of the drug, the spontaneous heart rates at rest and during exercise were significantly lower than before treatment. Propranolol injection now still increased the ventricular filling pressures at exercise but caused no significant effects on oxygen uptake, heart rate, cardiac output, stroke volume, or systemic vascular resistance.It is concluded that long-term beta-receptor blockade leads to a physiological adaptation including a persistent relative bradycardia and almost complete abolition of the haemodynamic response to acute adninistration of a beta-receptor blocking agent. It is suggested that this adaptation, which resembles that of physical training, constitutes one mechanism whereby long-term beta-receptor blockade is able to reduce the arterial blood pressure.

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“…Such observations tend to confirm for the dog similar observations made on man by roentgenographic technics. 17 ' 18 The change in ventricular dimensions in response to exercise varies in different animals. When the ventricle is small, diastolic expansion is prominent; when the ventricles are at or near their maximal size just before exercise, the stroke volume is apparently increased by greater systolic ejection.…”

Section: Resultsmentioning

confidence: 99%

Left Ventricular Dimensions Recorded by Sonocardiometry

Rushmer

Franklin²,

Ellis

1956

Circulation Research

185

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A new technic for continuously recording the dimensions of internal organs in intact unanesthetizcd animals has been developed as a modification of sonar technics. A sound is emitted by a small barium titanatc crystal mounted on one side of the left ventricle, and the time required for the sound waves to pass through the chamber to another crystal on the opposite side is monitored \ ,000 to 2,500 times/sec. Such crystals have continued to function reliably for more than 3 months after installation in the animal. Changes in left ventricular diameter have been recorded during spontaneous cardiac responses to various conditions including physical exertion on a treadmill. T HE function of the heart can be characterized and analyzed by measuring the changes in pressure, volume and flow of blood in the individual cardiac chambers. Although internal pressures can be readily measured by means of catheters, changes in the volume of the heart have been measured primarily by cardioineters in thoracotomized animals or by roentgenography in intact animals and men. These methods are not well suited to the study of cardiac control, which necessitates continuously measuring the absolute pressures and dimensions of the individual heart chambers in intact animals and man with regulating mechanisms intact and functioning. The volume of the individual cardiac chambers has never been measured satisfactorily in intact animals. Several technics have been employed in this laboratory to continuously record changes in the internal and external dimensions of the heart chambers. Initially, changes in the size and shape of the atria and ventricles were observed and measured on motion picture films obtained by cinefluorographic angiocardiography. 1 ' 2 Subsequently, new methods for continuously recording the changing dimensions have been explored. 1 ' 4 Variable resistance

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The Amount of Hemoglobin and the Blood Volume in Relation to the Pulse Rate and Cardiac Volume During Rest

Cited by 65 publications

References 6 publications

Comparison of Hemodynamic and Left Ventricular Responses to Increased After-Load in Healthy Males and Females

Comparison of Hemodynamic and Left Ventricular Responses to Increased After-Load in Healthy Males and Females

Effects remaining after withdrawal of long-term beta-receptor blockade. Reduced heart rate and altered haemodynamic response to acute propranolol administration.

Left Ventricular Dimensions Recorded by Sonocardiometry

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