The amphetamine–chlordiazepoxide mixture, a pharmacological screen for mood stabilizers, does not enhance amphetamine-induced disruption of prepulse inhibition

Douma, Tessa N.; Kolarz, Adam; Postma, Ynte; Olivier, Berend; Groenink, Lucianne

doi:10.1016/j.bbr.2011.07.032

Cited by 5 publications

(5 citation statements)

References 191 publications

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“…First, a correlation between substance dependence and inadequate response inhibition was found. Although this correlation was found only in drug dependence and absent for alcohol, these results correspond with research showing a relationship between disruption of inhibition and drugs (Douma, Kolarz, Postma, Olivier, & Groenink, 2011;Halberstadt & Geyer, 2010). Moreover, a relationship between drug dependence and impulsive decision making was found, which is in line with research showing a relationship between impulsive decision making and drug use (Cadet, Bisagno, & Milroy, 2014).…”

Section: Discussionsupporting

confidence: 89%

Modeling Impulsivity in Forensic Patients: A Three-Dimensional Model of Impulsivity

Tonnaer

Cima²,

Arntz

2016

The American Journal of Psychology

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The current study investigated whether a multidimensional model could underlie impulsivity and its associations with various disorders in a forensic sample. Data were available from self-report and behavioral impulsivity instruments of 87 forensic patients. Principal component analysis (PCA) was used to derive a dimensional impulsivity model, and the relationship between and possible predictive validity of impulsivity dimensions for psychopathology was investigated using product moment correlations and regression analysis. A 3-dimensional model of impulsivity was derived, with factors labeled impulsive decision making, sensation seeking, and response inhibition. Impulsive decision making was a predictor for a history of drug dependence, the impulsive lifestyle facet of psychopathy, and antisocial personality disorder. Sensation seeking was not related to any psychopathology. Inadequate response inhibition was a predictor for drug dependence, psychopathy, and antisocial personality disorder. Given the importance of the concept of impulsivity with regard to forensic risk assessment, the current results replicated earlier impulsivity models and imply that impulsivity is a crucial target for diagnosis and interventions and underlines the importance to consider impulsivity as a multidimensional construct.

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Section: Discussionsupporting

confidence: 89%

Modeling Impulsivity in Forensic Patients: A Three-Dimensional Model of Impulsivity

Tonnaer

Cima²,

Arntz

2016

The American Journal of Psychology

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“…Acute VPA attenuated hyperactivity in DAT KD mice while not affecting the activity of WT mice however (Ralph-Williams et al, 2003). Acute VPA treatment did not remediate GBR12909-induced hyperactivity in mice, leading to suggestions that the predictive validity of the GBR12909 model for BD mania should be examined using chronic treatment (Douma et al, 2011). In support of this point, treatment of BD mania requires chronic administration of a mood-stabilizer, nominally at least 3 weeks in clinical trials (Cipriani et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Chronic valproate attenuates some, but not all, facets of mania-like behaviour in mice

Enkhuizen

Geyer

Kooistra

et al. 2013

International Journal of Neuropsychopharmacology

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Bipolar Disorder (BD) mania is a psychiatric disorder with multifaceted symptoms. Development of targeted treatments for BD mania may benefit from animal models that mimic multiple symptoms, as opposed to hyperactivity alone. Using the reverse-translated multivariate exploratory paradigm, the Behavioral Pattern Monitor (BPM), we reported that patients with BD mania exhibit hyperactivity as well as increased specific exploration and more linear movements through space. This abnormal profile is also observed in mice with reduced function of the dopamine transporter (DAT) through either constitutive genetic (knockdown (KD)) or acute pharmacological (GBR12909) means. Here, we assessed the pharmacological predictive validity of these models by administering the BD-treatment valproic acid (VPA) for 28 days. After 28 days of 1.5% VPA- or regular-chow treatment, C57BL/6J mice received GBR12909 (9 mg/kg) or saline and were tested in the BPM. Similarly, DAT KD and WT littermates were treated with VPA-chow and tested in the BPM. GBR12909-treated and DAT KD mice on regular chow were hyperactive, exhibited increased specific exploration, and moved in straighter patterns compared to saline-treated and WT mice respectively. Chronic 1.5% VPA-chow treatment resulted in therapeutic concentrations of VPA and ameliorated hyperactivity in both models, while specific exploration and behavioral organization remained unaffected. Hence, the mania-like profile of mice with reduced functional DAT was partially attenuated by chronic VPA treatment, consistent with the incomplete symptomatic effect of VPA treatment in BD patients. Both DAT models may help to identify therapeutics that impact the full spectrum of BD mania.

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“…Moreover, treatment with acute (Ralph-Williams et al, 2003) or chronic valproate (van Enkhuizen et al, 2013c) or the dopamine synthesis inhibitor alpha-methyl-para-tyrosine (van Enkhuizen et al, 2014) attenuated some of these abnormal behaviors in mice, but not all. Another strength of these models for bipolar disorder mania is that they exhibit other abnormal behaviors implicated in bipolar disorder such as poor decision-making (Young et al, 2011b), increased motor impulsivity (van Enkhuizen et al, 2013b), increased motivation (Cagniard et al, 2006), and impaired prepulse inhibition (PPI) (Douma et al, 2011). Therefore, these animal models based on reduced dopamine transporter functioning support increased catecholamine functions underlying many of the abnormal behavior present in manic bipolar disorder patients.…”

Section: The Original Adrenergic-cholinergic Balance Hypothesis Ofmentioning

confidence: 99%

The catecholaminergic–cholinergic balance hypothesis of bipolar disorder revisited

Enkhuizen

Janowsky

Olivier

et al. 2015

European Journal of Pharmacology

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Bipolar disorder is a unique illness characterized by fluctuations between mood states of depression and mania. Originally, an adrenergic-cholinergic balance hypothesis was postulated to underlie these different affective states. In this review, we update this hypothesis with recent findings from human and animal studies, suggesting that a catecholaminergic-cholinergic hypothesis may be more relevant. Evidence from neuroimaging studies, neuropharmacological interventions, and genetic associations support the notion that increased cholinergic functioning underlies depression, whereas increased activations of the catecholamines (dopamine and norepinephrine) underlie mania. Elevated functional acetylcholine during depression may affect both muscarinic and nicotinic acetylcholine receptors in a compensatory fashion. Increased functional dopamine and norepinephrine during mania on the other hand may affect receptor expression and functioning of dopamine reuptake transporters. Despite increasing evidence supporting this hypothesis, a relationship between these two neurotransmitter systems that could explain cycling between states of depression and mania is missing. Future studies should focus on the influence of environmental stimuli and genetic susceptibilities that may affect the catecholaminergic-cholinergic balance underlying cycling between the affective states. Overall, observations from recent studies add important data to this revised balance theory of bipolar disorder, renewing interest in this field of research.

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The amphetamine–chlordiazepoxide mixture, a pharmacological screen for mood stabilizers, does not enhance amphetamine-induced disruption of prepulse inhibition

Cited by 5 publications

References 191 publications

Modeling Impulsivity in Forensic Patients: A Three-Dimensional Model of Impulsivity

Modeling Impulsivity in Forensic Patients: A Three-Dimensional Model of Impulsivity

Chronic valproate attenuates some, but not all, facets of mania-like behaviour in mice

The catecholaminergic–cholinergic balance hypothesis of bipolar disorder revisited

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