The analgesic action of desmopressin in renal colic

Kapila, Vansh; Kapila, Ayush K; Tailly, Thomas; Rappe, Bernard; Juul, Kristian Vinter; Everaert, Karel

doi:10.1080/17843286.2016.1230569

Cited by 8 publications

(8 citation statements)

References 19 publications

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“…Renal colic is a common urological condition, with a lifetime risk of around 12% in men and 6% in women (43), although estimates vary across studies and geographic regions. It refers to severe pain resulting from the presence of a stone in the urinary system causing acute obstruction, ureteric dilatation, tensile stretch and spasmodic activity (44)(45)(46). The ureter releases prostaglandins in response to the obstruction, rendering nociceptors sensitive to stimuli such as bradykinins that induce pain and Table IV other visceral responses such as nausea (47).…”

Section: Results Of Literature Review and Discussion Of Findingsmentioning

confidence: 99%

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Potential clinical applications of current and future oral forms of desmopressin (Review)

Everaert,

Holm‑larsen,

Bou Kheir

et al. 2024

Exp Ther Med

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Desmopressin is a synthetic analogue of vasopressin and a selective vasopressin receptor 2 agonist. It was first synthesised in 1967 and utilised for its antidiuretic properties. It is also used in bleeding disorders to enhance clotting. Other potential uses of the drug have been reported. The present review aims to provide a broad overview of the literature on potential further uses of oral forms of desmopressin. Key therapeutic areas of interest were identified based on known physiological activities/targets of desmopressin or reports of an effect of desmopressin in the literature. The feasibility of adequate dosing with oral forms of the drug was also considered. Systematic literature searches were carried out using the silvi.ai software for the identified areas, and summaries of available papers were included in tables and discussed. The results of the searches showed that desmopressin has been investigated for its efficacy in a number of areas, including bleeding control, renal colic, the central nervous system and oncology. Evidence suggests that oral desmopressin may have the potential to be of clinical benefit for renal colic and bleeding control in particular. However, further research is needed to clarify its effect in these areas, including randomised controlled studies and studies specifically of oral formulations (and doses). Further research may also yield findings for cancer, cognition and overactive bladder. Contents 1. Introduction 2. Methods 3. Results of literature review and discussion of findings 4. Conclusion

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Section: Results Of Literature Review and Discussion Of Findingsmentioning

confidence: 99%

“…In uncomplicated cases of stones up to 10 mm, a conservative approach may be taken, with observation for spontaneous passage for around 4-6 weeks ( 45 ). Medical expulsive therapy (MET) is commonly used to increase stone passage rate, decrease time to passage and decrease pain.…”

Section: Results Of Literature Review and Discussion Of Findingsmentioning

confidence: 99%

Potential clinical applications of current and future oral forms of desmopressin (Review)

Everaert,

Holm‑larsen,

Bou Kheir

et al. 2024

Exp Ther Med

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“…Despite dilatation, extension, and spastic activity of ureter in acute ureteric calculus obstruction, molecular research has revealed enhanced local release of inflammatory mediators, such as prostaglanin F2α (PGF2α) and 5-hydroxytryptamine (5-HT), and bradykinin synthesis, subsequently increasing renal intrapelvic pressure, resulting in severe and unbearable renal colic. [33][34][35] Although myogenic factors are essential in the control of ureteral peristalsis, sympathetic and parasympathetic nerves also play a role in this process. Ureteral contraction can be enhanced by via activating α 1 -adrenergic, muscarinic, purinergic, histamine H1 receptors on ureteric smooth muscle cells as well as increased substance P, 5-HT levels cohesively, and the ureter is dilated through activating β2/3-receptors and histamine H2 receptors and upregulating endothelial oxide and prostaglandin E1, E2 expressions.…”

Section: Potential Mechanisms Of Treatment Effectivenessmentioning

confidence: 99%

Acupuncture versus Lornoxicam in the Treatment of Acute Renal Colic: A Randomized Controlled Trial

Zhang¹,

Liu²,

Ye³

et al. 2021

JPR

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To compare the analgesic efficacy and safety of acupuncture and lornoxicam in acute renal colic (ARC). Design, Setting, Participant: A randomized, double-blind, parallel-controlled, singlecentered trial was conducted at Susong County People's Hospital from October 2019 to November 2020. Eighty-four patients with ARC were randomly divided into lornoxicam group (Group L) and acupuncture group (Group A). Group A was treated with acupuncture at Sanyinjiao (SP6), Yinlingquan (SP9) and normal saline, and Group L was treated with sham acupuncture at SP6, SP9 and lornoxicam. Main Outcome Measures: Visual analogue scale (VAS) scores and adverse reactions such as nausea and dizziness were recorded within 5, 10, 15, 20 and 40 minutes after treatment. The main outcome of this study was the short-term effective (STE) rate, the secondary outcome was the onset time, and the safety index was incidence of adverse reactions. Results: A total of 80 patients completed this study, including 41 patients (21 males and 20 females) in Group L and 39 patients (21 males and 18 females) in Group A. Group A exhibited lower scores versus group L after treatment (P < 0.05). The overall STE of group L was 61.00% (25/41), significantly lower than group A [84.62% (33/39)] (P < 0.001). There was no difference in the incidence of adverse reactions between group A [2.6% (1/39)] and group L [7.3% (3/41)] (P = 0.616). The ordered logistic regression analysis showed patients receiving acupuncture therapy are more likely to be cured [OR = 2.887, 95% CI: (1.190,7.000), P = 0.019]. Conclusion: Acupuncture at SP6, SP9 and intramuscular injection of lornoxicam can effectively and safely relieve ARC, but the former has faster and better analgesic effect. Moreover, the incidence of adverse reactions was similar between the two treatments. This acupuncture therapy is recommended as a complementary therapy for ARC.

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“…Desmopressin has few adverse effects with the most common being facial flushing. Other adverse effects include headache, decreased blood pressure, tachycardia, fatigue, and dizziness (33,41,42).…”

Section: Hormonesmentioning

confidence: 99%

Otorhinolaryngological adverse effects of urological drugs

2021

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Purpose: To describe the otorhinolaryngological adverse effects of the main drugs used in urological practice. Materials and Methods: A review of the scientifi c literature was performed using a combination of specifi c descriptors (side effect, adverse effect, scopolamine, sildenafi l, tadalafi l, vardenafi l, oxybutynin, tolterodine, spironolactone, furosemide, hydrochlorothiazide, doxazosin, alfuzosin, terazosin, prazosin, tamsulosin, desmopressin) contained in publications until April 2020. Manuscripts written in English, Portuguese, and Spanish were manually selected from the title and abstract. The main drugs used in Urology were divided into fi ve groups to describe their possible adverse effects: alpha-blockers, anticholinergics, diuretics, hormones, and phosphodiesterase inhibitors. Results: The main drugs used in Urology may cause several otorhinolaryngological adverse effects. Dizziness was most common, but dry mouth, rhinitis, nasal congestion, epistaxis, hearing loss, tinnitus, and rhinorrhea were also reported and varies among drug classes. Conclusions: Most of the drugs used in urological practice have otorhinolaryngological adverse effects. Dizziness was most common, but dry mouth, rhinitis, nasal congestion, epistaxis, hearing loss, tinnitus, and rhinorrhea were also reported. Therefore, doctors must be aware of these adverse effects to improve adherence to the treatment and to minimize damage to the health of patients.

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The analgesic action of desmopressin in renal colic

Cited by 8 publications

References 19 publications

Potential clinical applications of current and future oral forms of desmopressin (Review)

Potential clinical applications of current and future oral forms of desmopressin (Review)

Acupuncture versus Lornoxicam in the Treatment of Acute Renal Colic: A Randomized Controlled Trial

Otorhinolaryngological adverse effects of urological drugs

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