The Analgesic, Anti-Inflammatory and Anti-Pyretic Activities of Tinospora cordifolia

Hussain, Liaqat; Akash, Muhammad Sajid Hamid; Ain, Noorul; Rehman, Kanwal; Ibrahim, Muhammad

doi:10.17219/acem/27909

Cited by 45 publications

(23 citation statements)

References 52 publications

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“…Analgesic, anti-inflammatory, and antipyretic activity Whole plant or ethanol extract is used for analgesic activity. It was assessed by hot plate and abdominal writing method in albino rats [16].…”

Section: Kattupalli Et Almentioning

confidence: 99%

The Multi-Activity Herbaceous Vine - Tinospora Cordifolia

Kattupalli¹,

Vesta²,

Vangara³

et al. 2019

Asian J Pharm Clin Res

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Tinospora cordifolia (Willd.) Miers ex Hook. F. and Thoms is a large deciduous, climbing shrub found throughout India, especially in the tropical parts ascending to an altitude of 300 m and also in certain parts of China (Anonymous). It belongs to the family Menispermaceae. It is known as heart-leaved Moonseed plant in English, Guduchi in Sanskrit, and Giloy in Hindi. It is known for its immense application in the treatment of various diseases in the traditional ayurvedic literature. T. cordifolia, also named as “heavenly elixir,” is used in various ayurvedic decoctions as panacea to treat several body ailments. (Mishra R,) Its root stems, and leaves are used in Ayurvedic medicine. T. cordifolia is used for diabetes, high cholesterol, allergic rhinitis (hay fever), upset stomach, gout, lymphoma and other cancers, rheumatoid arthritis, hepatitis, peptic ulcer disease, fever, gonorrhea, syphilis, and to boost the immune system (WebMD).

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Section: Kattupalli Et Almentioning

confidence: 99%

The Multi-Activity Herbaceous Vine - Tinospora Cordifolia

Kattupalli¹,

Vesta²,

Vangara³

et al. 2019

Asian J Pharm Clin Res

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“…17 Hussain et al showed increase in mean latency time of tail flick (sec) in extract treated group in comparison with control group using mice as experimental animal and tramadol as standard drug in both tail flick and hot plate test. 18 Siddhalingappa et al also found out that T. cordifolia aqueous extract significant increase in the reaction time (pain threshold) in doses of 100 mg/kg, 200 mg/kg. 19 The evaluation of number of writhing revealed that both 100 mg/kg and 300 mg/kg doses of test drug reduces number of abdominal writhing significantly in comparison to control group.…”

Section: Discussionmentioning

confidence: 95%

“…Maximum inhibition in T300 group with no difference with standard drug when diclofenac sodium used as standard drug using mice as experimental animal (p value <0.05). 18 Bhomik et al has shown administration of this T. cordifolia extract orally and pentazocine intraperitoneally significantly reduce writhes counts (p<0.001 and p<0.001 respectively) when compared with the control group in sodium chloride (NaCl) induced abdominal writhing method using rats as experimental animal. 17…”

Section: Discussionmentioning

confidence: 99%

A study to evaluate efficacy of Tinospora cordifolia (Guduchi) as analgesic agent using albino wistar rats as an experimental animal model

Mandal

Das

Mandal

et al. 2020

Int J Basic Clin Pharmacol

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Background: Pain is a very well-known symptom of many diseases and analgesics are used to relieve pain. The main problem with these drugs remains that of side effects. Herbal medicines are better in view of their cultural acceptability, better compatibility with human body systems and lesser incidence of side effects. Extract of Tinospora cordifolia (Guduchi) plant have been traditionally used to treat pain in traditional medicine.Methods: Commercially available preparation of T. cordifolia plant has been used as test drug (aqueous extract). Healthy albino rats of either sex, weighing between 140-200 g were selected for the study, divided into 4 groups of 6 each (control, standard, 100 mg/kg, 300 mg/kg). Central analgesic activity was assessed by tail flick model (morphine as standard drug I.P). Acetic acid 1% 10 ml/kg aqueous solution I.P. was used for abdominal writhing model. Diclofenac 150 mg/kg oral as standard drug for assessment of peripheral analgesic activity. Results were analysed using SPSS version 16 and Microsoft office excel 2007.Results: T. cordifolia extract significantly increased the tail flick latency time (sec) (mean tail flick latency control, T100, T300 6.833±0.25 sec, 8.65±017 sec, 10.01±0.14 respectively) (p value control vs T100, T300 at 90 min, 120 min, 0.0573, 0.0198, 0.0198 in between group) and decreased number of abdominal writhing in comparison with the control group (p value <0.0001).Conclusions: Extract of T. cordifolia was found to possess analgesic activity and also exhibited dose and time dependant increase involving central and peripheral mechanisms. The analgesic activity of T. cordifolia found to be comparable to standard drug used.

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“…50 Furthermore, these factors are also considered to be conducive Antioxidant, antimicrobial, antitoxic effects, antistress, hepatic disorder, anti-HIV potential, wound healing, 23 analgesic, anti-inflammatory, antipyretic. 33…”

Section: Ayurveda and Host Defense Factorsmentioning

confidence: 99%

Ayurveda Arsenal for Strengthening Host Defense System against SARS-CoV-2 Infection and Need for Whole System Research

Singh¹,

Goel²,

Londhe³

et al. 2020

Journal of Research in Ayurvedic Sciences

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become a major public health menace. Along with the conventional medicine, Ayurveda is also exploring various single herbs and compound formulations against coronavirus disease-2019 (COVID-19). The present paper is an attempt to explore the Ayurveda arsenal in strengthening the host defense system against SARS-CoV-2 infection and the relevance and necessity for whole system research. For the present study, Ayurveda classics, Ayurveda Pharmacopoeia, and Formulary were probed to obtain an insight into the diseases as well as relevant therapeutic formulations. The electronic databases Google Scholar and PubMed were searched for relevant contemporary literature. The host response to SARS-CoV-2 infection is either well-coordinated healthy or dysfunctional immune responses. It is crucial to determine the host factors that influence the consequences of host-agent interaction. Factors conducive to the maintenance of good health (Swasthyam yena anuvartate) and preventing the attacks of diseases (Ajatanam Vikaranam Anutpattikara) mentioned in Ayurveda may be considered as pivotal factors influencing homoeostatic (Samayogavahi) mechanisms of host defense system (Vyadhi-Utpada-Pratibandhakatvam and Vyadhi-Bala-Virodhitvam). Furthermore, it is observed that current research practice of Ayurveda is predominantly drug-based, reflecting the perspective of conventional medicine module, however, compromising the core principles of Ayurveda. Finding effective solutions to COVID-19 pandemic, the Ayurveda arsenal for strengthening host defense system needed to be explored. The holistic method of Ayurveda followed in its clinical practice is needed to be adopted for clinical research as well, with focus on whole system research as compared to drug-based in order to generate tangible evidence.

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The Analgesic, Anti-Inflammatory and Anti-Pyretic Activities of Tinospora cordifolia

Cited by 45 publications

References 52 publications

The Multi-Activity Herbaceous Vine - Tinospora Cordifolia

The Multi-Activity Herbaceous Vine - Tinospora Cordifolia

A study to evaluate efficacy of Tinospora cordifolia (Guduchi) as analgesic agent using albino wistar rats as an experimental animal model

Ayurveda Arsenal for Strengthening Host Defense System against SARS-CoV-2 Infection and Need for Whole System Research

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