The Analgesic Effect of Botulinum-toxin A on Postwhiplash Neck Pain

Braker, Clara; Yariv, Shahak; Adler, Rivka; Badarny, Samih; Eisenberg, Elon

doi:10.1097/ajp.0b013e318156d90c

Cited by 29 publications

(35 citation statements)

References 33 publications

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“…One aspect that makes it difficult to reproduce certain studies is that the specific muscles injected are not identified in the study reports [30, 31, 34, 37]. Other studies sometimes do not give a complete description; for example, Lew et al report that the trapezius, levator scapulae, splenius capitis, and other posterior neck muscles were injected [32].…”

Section: Resultsmentioning

confidence: 99%

Botulinum Toxin for the Treatment of Myofascial Pain Syndromes Involving the Neck and Back: A Review from a Clinical Perspective

Climent

Kuan

Fenollosa³

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Introduction. Botulinum toxin inhibits acetylcholine (ACh) release and probably blocks some nociceptive neurotransmitters. It has been suggested that the development of myofascial trigger points (MTrP) is related to an excess release of ACh to increase the number of sensitized nociceptors. Although the use of botulinum toxin to treat myofascial pain syndrome (MPS) has been investigated in many clinical trials, the results are contradictory. The objective of this paper is to identify sources of variability that could explain these differences in the results. Material and Methods. We performed a content analysis of the clinical trials and systematic reviews of MPS. Results and Discussion. Sources of differences in studies were found in the diagnostic and selection criteria, the muscles injected, the injection technique, the number of trigger points injected, the dosage of botulinum toxin used, treatments for control group, outcome measures, and duration of followup. The contradictory results regarding the efficacy of botulinum toxin A in MPS associated with neck and back pain do not allow this treatment to be recommended or rejected. There is evidence that botulinum toxin could be useful in specific myofascial regions such as piriformis syndrome. It could also be useful in patients with refractory MPS that has not responded to other myofascial injection therapies.

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Section: Resultsmentioning

confidence: 99%

Botulinum Toxin for the Treatment of Myofascial Pain Syndromes Involving the Neck and Back: A Review from a Clinical Perspective

Climent

Kuan

Fenollosa³

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…Many studies reported that BoNT/A alleviated various kinds of pain [41][42][43][44]. It has been assumed from the rat model that an antinociceptive effect of BoNT/A may be derived from blockage of substance P or glutamate release [45].…”

Section: Discussionmentioning

confidence: 99%

Interventions for hemiplegic shoulder pain: Systematic review of randomised controlled trials

Koog

Jin

Yoon

et al. 2010

Disability and Rehabilitation

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“…However, the other tennis elbow study by Hayton et al (2005) did not demonstrate the usefulness of BoNTA in reducing pain. In addition, BoN-TA did not significantly improve pain scores among the small number of shoulder pain and whiplash injury studies (Singh et al 2009;Braker et al 2008;Carroll et al 2008;Padberg et al 2007). Back pain was evaluated in one RCT in our systematic review (Foster et al 2001).…”

Section: Total (95% Ci)mentioning

confidence: 99%

“…The three studies all recruited patients with a history of a whiplash injury and subsequent localized neck pain (Braker et al 2008;Carroll et al 2008;Padberg et al 2007). However, the duration of symptoms prior to trial enrolment was not consistent among the studies, ranging from 2 weeks to a year.…”

Section: Whiplash Associated Disordermentioning

confidence: 99%

The efficacy of botulinum toxin type A in managing chronic musculoskeletal pain: a systematic review and meta analysis

et al. 2010

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In our meta-analysis, BoNTA had a small to moderate analgesic effect in chronic musculoskeletal pain conditions. It was particularly effective in plantar fasciitis, tennis elbow, and back pain, but not in whiplash or shoulder pain patients. However, more evidence is required before definitive conclusions can be drawn. On the other hand, there is convincing evidence that BoNTA lacks strong analgesic effects in patients with myofascial pain syndrome. A general dose-dependent and temporal response with BoNTA injections was also observed.

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The Analgesic Effect of Botulinum-toxin A on Postwhiplash Neck Pain

Abstract: Study results suggest that BTXA treatment has some efficacy when administered within 1 year of the WI. However, a large, well-designed clinical trial is needed to draw final conclusions.

Cited by 29 publications

References 33 publications

Botulinum Toxin for the Treatment of Myofascial Pain Syndromes Involving the Neck and Back: A Review from a Clinical Perspective

Botulinum Toxin for the Treatment of Myofascial Pain Syndromes Involving the Neck and Back: A Review from a Clinical Perspective

Interventions for hemiplegic shoulder pain: Systematic review of randomised controlled trials

The efficacy of botulinum toxin type A in managing chronic musculoskeletal pain: a systematic review and meta analysis

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