2002
DOI: 10.1213/00000539-200210000-00036
|View full text |Cite
|
Sign up to set email alerts
|

The Analgesic Effect of Gabapentin and Mexiletine After Breast Surgery for Cancer

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

4
79
2
1

Year Published

2004
2004
2015
2015

Publication Types

Select...
5
2

Relationship

0
7

Authors

Journals

citations
Cited by 216 publications
(86 citation statements)
references
References 17 publications
4
79
2
1
Order By: Relevance
“…In a randomized, placebo-controlled trial, the incidence of CPSP and pain scores did not differ between study arms. Similarly, in their second trial comparing mexiletine to gabapentin and placebo, no significant difference was found between trial groups [64]. Within the past year, an additional five studies have been published evaluating the use of local anesthetics for CPSP [12][13][14][15][16].…”
Section: Local Anestheticsmentioning
confidence: 99%
See 1 more Smart Citation
“…In a randomized, placebo-controlled trial, the incidence of CPSP and pain scores did not differ between study arms. Similarly, in their second trial comparing mexiletine to gabapentin and placebo, no significant difference was found between trial groups [64]. Within the past year, an additional five studies have been published evaluating the use of local anesthetics for CPSP [12][13][14][15][16].…”
Section: Local Anestheticsmentioning
confidence: 99%
“…Utilizing different classes of medication to target different peripheral and CNS mechanisms to reduce acute pain, reducing opioid analgesic requirements postoperatively and improving opioid related side effects has been shown to be successful in clinical trials [60,64]. However, RCTs that examine specific surgery-related multimodal regimens versus placebo and follow patients for preventive analgesic effects (i.e., 3 months or greater following surgery) are limited.…”
Section: Multimodal Analgesiamentioning
confidence: 99%
“…Both drugs, in earlier clinical trials, have been used as a preemptive analgesic and found to be safe and effective. [3][4][5]12,13 The preemptive administration of gabapentin and tramadol approximately two hours before surgery appears rational in order to attain maximal plasma concentrations at the time of surgical stimuli. It has also been demonstrated that a single dose of 600 mg of gabapentin added to 60 mg slow release morphine increases pain tolerance to the cold pressure test in humans.…”
Section: Objectifmentioning
confidence: 99%
“…12 Although gabapentin has been used in the treatment of neuropathic pain syndromes, it has also demonstrated potent antihyperalgesic proprieties in preclinical and clinical studies, without affecting acute nociception. 5,6,[12][13][14][15][16] In experimental studies gabapentin suppressed experimentally induced hyperalgesia and its intrathecal administration reduced tactile allodynia after incision. Gabapentin enhanced pain behaviour in rats after formalin-induced pain and reduced mechanical hyperalgesia in a rat model of postoperative pain.…”
Section: Méthodementioning
confidence: 99%
See 1 more Smart Citation