2004
DOI: 10.1016/j.jep.2003.09.021
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The analgesic effect of the methanolic extract of Acanthus montanus

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Cited by 79 publications
(51 citation statements)
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“…The pronounced inhibition of writhes by the extract suggests that its effect may be peripherally-mediated via the inhibition of synthesis and/or release of prostaglandins. The increased reaction time of the mice pretreated with the extract in the hot plate model suggests that it might be centrally acting since centrally acting analgesic drugs are known to elevate the pain threshold of animals towards heat and pressure [13].…”
Section: Discussionmentioning
confidence: 99%
“…The pronounced inhibition of writhes by the extract suggests that its effect may be peripherally-mediated via the inhibition of synthesis and/or release of prostaglandins. The increased reaction time of the mice pretreated with the extract in the hot plate model suggests that it might be centrally acting since centrally acting analgesic drugs are known to elevate the pain threshold of animals towards heat and pressure [13].…”
Section: Discussionmentioning
confidence: 99%
“…In our earlier studies, we demonstrated that the methanol extract of Acanthus montanus produced relaxation of intestinal smooth muscles [3], and possessed analgesic [4] and anti-inflammatory [5] activities. Several other pharmacological studies have shown the antiinflammatory, antipyretic, antimicrobial and immunologic properties of the leaves of this plant [6,7].…”
Section: Introductionmentioning
confidence: 94%
“…Chasmanthera dependens (Morebise et al, 2001); Acanthus montanus (Adeyemi et al, 2004); Bysorcarpus coccineus (Akindele and Adeyemi, 2007), Stereospermum kunthianum (Ching et al, 2009), Sclerocarya birrea (Ojewole, 2004), Harpagophytum procumbens (Mahomed and Oyewole, 2004;Anilkumar, 2010), Tithonia diversifolia (Owoyele et al, 2004), Palisota hirsuta ( Wood et al, 2009;Boakye-Gyasi et al, 2011), Zingiber officinale (Ojewole, 2006;Anilkumar, 2010), Hippocratea indica and Poga oleosa (Ogbole et al, 2007), Securidaca longepedunculata (Ojewole, 2008), Tetrapleura tetraptera (Ojewole, 2009), Parquetina nigrescens (Owoyele et al, 2008), Hunteria umbellate (Adeneye et al, 2011).…”
Section: Pharmacological Activity Of Some Plants Used In the Treatmenmentioning
confidence: 99%