The analgesic effect of three different doses of nitroglycerine when added to lidocaine for intravenous regional anesthesia in trauma patients

Honarmand, Azim; Safavi, Mohammadreza; Fatemy, Abbas

doi:10.5505/tjtes.2011.30643

Cited by 10 publications

(8 citation statements)

References 31 publications

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“…Similar to our study and for the first time, Sen et al 9 demonstrated that the NTG with the similar dose of 200 μg led to lower that postoperative VAS scores were significantly lower for the first 4 h postoperatively. In another study by Abbasivash et al 10 and using similar dose of NTG as 200 μg, the sensory and motor block onset time were shortened, the recovery time of sensory and motor block and onset of tourniquet pain were prolonged, analgesia time after tourniquet deflation was prolonged and tourniquet pain intensity was also lowered in study group with no significant side effects. Besides, Honarmand et al 10 revealed that the addition of 400 μg NTG to LID improved the speed of onset and the quality of anesthesia and decreased tourniquet pain and intraoperative and postoperative analgesic consumption better than the addition of the other two doses of 200 μg or 300 μg NTG, without any significant side effects.…”

Section: Discussionmentioning

confidence: 87%

“…In another study by Abbasivash et al 10 and using similar dose of NTG as 200 μg, the sensory and motor block onset time were shortened, the recovery time of sensory and motor block and onset of tourniquet pain were prolonged, analgesia time after tourniquet deflation was prolonged and tourniquet pain intensity was also lowered in study group with no significant side effects. Besides, Honarmand et al 10 revealed that the addition of 400 μg NTG to LID improved the speed of onset and the quality of anesthesia and decreased tourniquet pain and intraoperative and postoperative analgesic consumption better than the addition of the other two doses of 200 μg or 300 μg NTG, without any significant side effects. In fact, although administration of NTG 200 μg can be appropriate for obtaining optimal time for the onset of sensory and motor block and recovery time of sensory blockade, but the increase of its dosages up to 400 μg can lead to achieving higher quality of anesthesia and more decrease in tourniquet pain 11 .…”

Section: Discussionmentioning

confidence: 87%

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The analgesic effect of nitroglycerin added to lidocaine on quality of intravenous regional anesthesia in patients undergoing elective forearm and hand surgery

Asadi

Mehri

2013

Acta Cir. Bras.

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PURPOSE:To evaluate the effect of nitroglycerine (NTG) on sensory and motor block onset and recovery time as well as the quality of tourniquet pain relief, when added to lidocaine (LID) for intravenous regional anesthesia in elective forearm and hand surgery. METHODS:A randomized double-blinded clinical trial was performed on 40 patients that were randomly allocated into two groups received lidocaine 3 mg/kg with NTG 200 µg or received only lidocaine 3 mg/kg as the control. RESULTS:There was no difference between the two study groups in hemodynamic parameters before tourniquet inflation, at any time after inflation and after its deflation. There was no difference in the mean of pain score over time between the two groups. The onset time of sensory and motor blockades was shorter in the group received both LID and NTG. The mean recovery time of sensory blockade was longer in the former group. The frequency of opioid injections was significantly lower in those who administered LID and NTG. CONCLUSION:The adjuvant drug of NTG when added to LID is effective in improving the overall quality of anesthesia, shortening onset time of both sensory and motor blockades, and stabling homodynamic parameters in hand and forearm surgery.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 87%

The analgesic effect of nitroglycerin added to lidocaine on quality of intravenous regional anesthesia in patients undergoing elective forearm and hand surgery

Asadi

Mehri

2013

Acta Cir. Bras.

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“…[1] IVRA has some disadvantages that include slow onset of sensory and motor block, inadequate muscle relaxation, toxicity of local anesthetic (LA), tourniquet pain, and short duration of postoperative analgesia. [123456]…”

Section: Introductionmentioning

confidence: 99%

Adding metoclopramide to lidocaine for intravenous regional anesthesia in trauma patients

2014

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Background:Metoclopromide have local anesthetic properties. The main object of performing the present study was to evaluate the analgesic effect of metoclopromide 10 mg when added to lidocaine for intravenous regional anesthesia (IVRA) of upper extremities in trauma patients.Materials and Methods:Ninety patients undergoing upper limb producer were randomly allocated to the three groups to receive 3 mg/kg 2% lidocaine diluted with saline to a total dose of 40 ml (Group L, n = 30) or 10 mg metoclopromide plus 3 mg/kg 2% lidocaine diluted with saline to a total dose of 40 ml (group LM, n = 30) or 3 mg/kg 2% lidocaine diluted with saline to a total dose of 40 ml plus 10 mg metoclopromide intravenously (Group IM, n = 30).Results:Our study showed that the onset times for sensory and motor block were significantly shorter in Group LM compared with Group L and Group IM (4.5 ± 0.7 vs. 5.0 ± 0.7 and 5.0 ± 0.6, respectively, P = 0.006 for sensory block; 6.3 ± 0.7 vs. 5.1 ± 0.9 and 5.9 ± 0.6 respectively, P = 0.000 for motor block). The postoperative VAS scores were significantly less at 1, 5, 10, 15, and 30 minutes after tourniquet release in Group LM compared with Group L and Group IM (P < 0.05).Conclusion:The results of our study showed that adding 10 mg metoclopromide to lidocaine for IVRG in trauma patients reduced intraoperative and postoperative analgesic use till 24 hours and improve quality of anesthesia.

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“…5-HT3 receptor antagonists decrease serotonin-induced release of substance P from C-fiber. [31] It has been shown that when the drugs with local anesthetic properties such as meperidine,[32] clonidine[33] or nitroglycerine[3435] added to the local anesthetic solution in IVRG, they can reduce tourniquet and postoperative pain. As it was shown by Ye J and colleagues,[8] ondansetron has potent local anesthetic properties.…”

Section: Discussionmentioning

confidence: 99%

Effect of adding 8 milligrams ondansetron to lidocaine for Bier′s block on post-operative pain

2013

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Background:Ondansetron has analgesic properties. The aim of the present study was to assess the analgesic effect of 8 mg ondansetron when added to lidocaine for intravenous regional anesthesia (IVRA).Materials and Methods:Ninety patients undergoing hand surgery were randomly allocated to the three groups to receive 3 mg/kg 2% lidocaine diluted with saline to a total dose of 40 mL (Group L, n = 30) or 8 mg ondansetron plus 3 mg/kg 2% lidocaine diluted with saline to a total dose of 40 mL (group LO, n = 30) or 3 mg/kg 2% lidocaine diluted with saline to a total dose of 40 mL plus 8 mg ondansetron intravenously (Group IO, n = 30). Tourniquet pain and analgesic use were recorded before and after the tourniquet application.Results:The sensory and motor block onset times were significantly shorter in Group LO compared with Group L and Group IO (4.2 ± 1.7 vs. 5.2 ± 0.8 and 5.1 ± 1.2 respectively, P < 0.05; 4.5 ± 1.4 vs. 5.8 ± 1.5 and 5.7 ± 1.4 respectively, P < 0.05). The sensory and motor block recovery times were significantly longer in Group LO compared with Group L and Group IO (6.1 ± 1.1 vs. 4.1 ± 1.3 and 4.5 ± 0.9 respectively, P < 0.05; 6.7 ± 1.4 vs. 4.4 ± 0.9 and 4.7 ± 0.7 respectively, P < 0.05). Post-operative VAS scores were significantly less in Group LO compared with Group L and Group IO till 24 h after tourniquet deflation (P < 0.05).Conclusion:The addition of 8 mg ondansetron to lidocaine for IVRA reduced intraoperative and post-operative analgesic use till 24 h.

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The analgesic effect of three different doses of nitroglycerine when added to lidocaine for intravenous regional anesthesia in trauma patients

Cited by 10 publications

References 31 publications

The analgesic effect of nitroglycerin added to lidocaine on quality of intravenous regional anesthesia in patients undergoing elective forearm and hand surgery

The analgesic effect of nitroglycerin added to lidocaine on quality of intravenous regional anesthesia in patients undergoing elective forearm and hand surgery

Adding metoclopramide to lidocaine for intravenous regional anesthesia in trauma patients

Effect of adding 8 milligrams ondansetron to lidocaine for Bier′s block on post-operative pain

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