The analgesic efficacy of oxycodone hydrochloride versus fentanyl during outpatient artificial abortion operation

Abstract

Background:Problems like body movement, respiratory depression, and complained of pain are still common phenomenon in outpatient artificial abortion general anesthesia. Oxycodone hydrochloride is a semisynthetic opioid and has a good therapeutic effect on visceral pain. We hypothesize that oxycodone hydrochloride would be superior to fentanyl in outpatient artificial abortion surgery.Methods:In this clinical trial 149 American Society of Anesthesiologists (ASA) I or II female outpatients scheduled for elective artificial abortion surgeries under general anesthesia were randomly divided into 3 groups: oxycodone hydrochloride 0.06 mg/kg group (group A), oxycodone hydrochloride 0.08 mg/kg group (group B), and control group fentanyl 2 ug/kg (group C). The primary outcome was level body movement and respiratory depression during the surgery, the second outcome included the visual analogue scale (VAS) score 30 minutes after waking.Results:A total of 120 participants completed the study, n = 40 in each group. There was no significant difference in patients’ age, body mass index (BMI), preoperative heart rate, mean arterial blood pressure, consumption dose of propofol, intraoperative body movement type and times, and duration of surgery among the 3 groups (P > .05). Comparing the incidence of intraoperative respiratory depression and SPO2 < 90% among the 3 groups, group C's was significantly higher than those of groups A and B, and the difference was statistically significant (P < .05). Group A had no difference compared with group B. In VAS score 30minutes after waking, group C was the highest, followed by group A, with group B as the lowest. The difference among the 3 groups was statistically significant (P < .05), but a difference delta less than 1 on the VAS scale is not clinically significant.Conclusion:The analgesic effect of oxycodone hydrochloride at 0.06 mg/kg applied to painless artificial abortion surgery is not superior than that of fentanyl, but the incidence of intraoperative respiratory depression and hypoxemia is significantly lower than fentanyl.

Safety and efficacy of intravenous oxycodone in geriatric patients undergoing general anesthesia for ophthalmic surgeries:a randomized controlled trial

“…This concept was confirmed by other studies. Xie et al showed that patients receiving higher dose of oxycodone exhibited more delayed awakening and more drowsiness (higher RSS score) comparing to fentanyl [25]. However, different from our results, they found higher incidence of intraoperative respiratory depression and hypoxia in the fentanyl group [25].…”

<p>Oxycodone vs Sufentanil in Patient-Controlled Intravenous Analgesia After Gynecological Tumor Operation: A Randomized Double-Blind Clinical Trial</p>

“…11,17 Opioids, the most commonly used type of analgesics for PCIA, have a clinical limitation because of side effects such as respiratory depression. 18 Many studies have investigated the effects of oxycodone for postoperative analgesia, 2,16,[19][20][21][22][23] however it is still controversial whether oxycodone can provide better transition analgesia and PCIA after gynecological tumors surgery under general anesthesia when compared with sufentanil. In our preliminary study, sufentanil PCIA without background infusion was applied; however, the intervals between bonus analgesia were too short (approximately 1 hour), which severely interfered patients' recovery and rest especially in the evening.…”

Comparison of oxycodone hydrochloride and sufentanil used in painless fiberbronchoscopy

“…Action of the anesthetic drugs may be explained as follows: (1) inhibitory effect of sufentanil with μ receptor typical respiration can produce synergistic effect with propofol. Oxycodone produces analgesia by μ and κ receptors inhibiting the respiration itself, may be light, and does not significantly increase the propofol respiratory inhibition; 8 (2) sufentanil group may not provide enough inhibition of stress response of the airway, causing cough and airway spasm, checking the bronchoscopic placement, which in turn may result in a decline in ventilation and reduce SpO 2 . In addition, oxycodone has a good analgesic effect.…”