The analog of arginine-vasopressin (6-9) fragment, Ac-D-SPRG, exhibits antidepressant action in rats in case of intranasal injection

Belyakova, A. S.; Sinjushin, Andrey; Voskresenskaya, O.G.; Kamensky, A.A.; Golubovich, V. P.

doi:10.1134/s1819712415030034

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Several studies were conducted in animal models using different routes of administration of AVP. Acute intranasal AVP (IN-AVP) administration in animal models has shown different results on pro-social effects [34,35]. Ramos et al [36] studied the effects of inhaled vasopressin on sociability, body temperature, and heart rate in rats.…”

Section: Resultsmentioning

confidence: 99%

Vasopressin in the Amelioration of Social Functioning in Autism Spectrum Disorder

Hendaus

Jomha

Alhammadi

2019

JCM

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Autism spectrum disorder (ASD) is a developmental disability described by diagnostic criteria that comprise deficits in social communication and the existence of repetitive, restricted patterns of behavior, interests, or activities that can last throughout life. Many preclinical studies show the importance of arginine vasopressin (AVP) physiology in social functioning in several mammalian species. Currently, there is a trend to investigate more specific pharmacological agents to improve social functioning in patients with ASD. Neurobiological systems that are crucial for social functioning are the most encouraging conceivable signaling pathways for ASD therapeutic discovery. The AVP signaling pathway is one of the most promising. The purpose of this commentary is to detail the evidence on the use of AVP as an agent that can improve social functioning. The pharmacologic aspects of the drug as well as its potential to ameliorate social functioning characteristics in human and animal studies are described in this manuscript. AVP, especially in its inhaled form, seems to be safe and beneficial in improving social functioning including in children with autism. Larger randomized studies are required to implement a long awaited safe and feasible treatment in people with a deficiency in social functioning.

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Section: Resultsmentioning

confidence: 99%

Vasopressin in the Amelioration of Social Functioning in Autism Spectrum Disorder

Hendaus

Jomha

Alhammadi

2019

JCM

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“…( 12 )] and certain single-nucleotide polymorphisms of the genes for AVP and its receptor ( 13 ) have been correlated with social functioning in individuals with ASD. Given the frequently pro-social effects of acute intranasal AVP (IN-AVP) administration in humans ( 14 – 16 ) and animal models ( 17 , 18 ), IN-AVP has been suggested as a treatment for the social deficits in children with ASD ( 19 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

Early Intranasal Vasopressin Administration Impairs Partner Preference in Adult Male Prairie Voles (Microtus ochrogaster)

et al. 2017

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Research supports a modulatory role for arginine vasopressin (AVP) in the expression of socially motivated behaviors in mammals. The acute effects of AVP administration are demonstrably pro-social across species, providing the justification for an ever-increasing measure of clinical interest over the last decade. Combining these results with non-invasive intranasal delivery results in an attractive system for offering intranasal AVP (IN-AVP) as a therapeutic for the social impairments of children with autism spectrum disorder. But, very little is known about the long-term effects of IN-AVP during early development. In this experiment, we explored whether a single week of early juvenile administration of IN-AVP (low = 0.05 IU/kg, medium = 0.5 IU/kg, high = 5.0 IU/kg) could impact behavior across life in prairie voles. We found increases in fecal boli production during open field and novel object recognition testing for the medium dose in both males and females. Medium-dose females also had significantly more play bouts than control when exposed to novel conspecifics during the juvenile period. Following sexual maturity, the medium and high doses of IN-AVP blocked partner preference formation in males, while no such impairment was found for any of the experimental groups in females. Finally, the high-dose selectively increased adult male aggression with novel conspecifics, but only after extended cohabitation with a mate. Our findings confirm that a single week of early IN-AVP treatment can have organizational effects on behavior across life in prairie voles. Specifically, the impairments in pair-bonding behavior experienced by male prairie voles should raise caution when the prosocial effects of acute IN-AVP demonstrated in other studies are extrapolated to long-term treatment.

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Peptide Hormones in Medicine: A 100-Year History

Martinovich

Baradzina

2022

Russ J Bioorg Chem

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This review is devoted to the 100-year history of the investigation of peptide hormones and the creation of drugs on their basis, starting from the insulin discovery and its introduction into a medical practice in 1921. The basic groups of the peptide hormones are discussed: neurohypophyseal hormones, hypothalamic releasing hormones, incretins, insulin, adrenocorticotropic hormone (ACTH), and calcitonin. The first therapeutic agents based on the peptide hormones were created by a traditional approach that involved the isolation of peptides from animal tissues, their purification to individual compounds, determination of their primary structure, their chemical synthesis or their deep purification, and the creation of a pharmaceutical substance. A modern approach to creation of peptide hormone drugs is based on their consideration as ligands of the corresponding cellular receptors and the use of computer modeling, efficient synthesis methods, and high-throughput screening. The combination of these methods enabled the development of analogs which would be more active than the corresponding natural compounds, exhibit other activities in addition to the hormonal regulation, and be resistant to biodegradation. Such therapeutic agents have been designed on the basis of agonistic and antagonistic analogs of somatostatin and luliberin, and have found wide application in hormonal regulation and cancer treatment. Over the past two decades, the glucagon-like peptide (GLP-1) has been intensively investigated as a potential therapeutic agent. In our review, we describe modifications which resulted in the most highly effective long-acting drugs. Now, natural hormones and their analogs are widely present in the pharmaceutical market.

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The analog of arginine-vasopressin (6-9) fragment, Ac-D-SPRG, exhibits antidepressant action in rats in case of intranasal injection

Cited by 3 publications

References 22 publications

Vasopressin in the Amelioration of Social Functioning in Autism Spectrum Disorder

Vasopressin in the Amelioration of Social Functioning in Autism Spectrum Disorder

Early Intranasal Vasopressin Administration Impairs Partner Preference in Adult Male Prairie Voles (Microtus ochrogaster)

Peptide Hormones in Medicine: A 100-Year History

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