The Analysis of Cases Admitted to Intensive Care Units from Emergency Department Due to Complications Related to Warfarin Treatment

Eroğlu, Murat; Çınar, Orhan; Çevik, Erdem; Yamanel, Levent; Durusu, Murat; İnal, Volkan; Cömert, Bilgin

doi:10.5505/1304.7361.2011.59455

Cited by 5 publications

(14 citation statements)

References 17 publications

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“…The average age of the patients in this study was 67.2±13.9. This is consistent with the information that patients with advanced age are more prone to warfarin-dependent complications, which is reported by some studies in the literature (8).…”

Section: Discussionsupporting

confidence: 93%

“…Its usage might cause many complications, such as bleeding in organs and tissues, in particular, as it has a narrow therapeutic range (10). The decision to administer warfarin is based on the delicate balance between the reduced risk of thromboembolism and increased risk of bleeding (8). In such a case, it is highly important to analyze and identify the potential complications dependent on warfarin use.…”

Section: Discussionmentioning

confidence: 99%

“…Nowadays, physicians use warfarin therapy more frequently for the older population, in particular, and this might result in bleeding complications (11). Although no study has ever entirely enlightened the relation between age and bleeding complications, some studies have indicated that it increases in patients over the age of 80 and that it increases significantly for each decade after 40 (8,12). Other studies with counterarguments have reported that it is not a significant determining factor for bleeding complications in patients using it (8).…”

Section: Discussionmentioning

confidence: 99%

“…The most frequent and severe complication likely to occur in patients receiving warfarin therapy is hemorrhage in organs and tissues (4,7). In cases of warfarin therapy-dependent hemorrhage, if it is not diagnosed early and treated properly, it progresses rapidly and threatens life (8). Considering the fact that patients with such complications frequently are admitted to emergency departments, it is evident that emergency departments play a vital role in the effective and proper treatment of this patient group.…”

Section: Introductionmentioning

confidence: 99%

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The Analysis of Patients Admitted to the Emergency Department Due to Complications Related to Warfarin Treatment

Sayhan¹,

Oguz²,

Yüksel³

et al. 2014

JAEM

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Objective: Warfarin is the most commonly used oral anticoagulant around the world. The most important complication of warfarin is bleeding. This study was conducted to evaluate the patients who were admitted to our emergency department due to complications related to warfarin treatment. Material and Methods:Eighty-nine patients (32 females, 57 males) were enrolled into this retrospective study. The patients were evaluated according to their age, gender, duration of therapy (year), co-administered drugs, bleeding localization, treatments, amount of blood transfusions, duration of bleeding, initial and after-treatment PT, INR, complete blood count, and aPTT.Results: Mean duration of anticoagulant use was 3.05±2.87 years. The most common indication of warfarin was atrial fibrillation. The most frequent bleeding localization was the upper gastrointestinal tract. Thirty-four (38.2%) of the patients had major bleeding, and 55 (61.8%) had minor bleeding. Age, co-administered drugs, amount of erythrocyte suspension transfusion, presence of previous warfarin overdose history, Hb levels at admission, and duration of follow-up in the ED were different between the bleeding types. Conclusion:In this study, we found that the bleeding complications of warfarin were associated with the aged population, presence of previous warfarin overdose history, and concomitant drug use. (JAEM 2014; 13: 194-8)

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Analysis of Patients Admitted to the Emergency Department Due to Complications Related to Warfarin Treatment

Sayhan¹,

Oguz²,

Yüksel³

et al. 2014

JAEM

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“…Anticoagulant agents are widely used for the treatment of strokes induced by thromboembolism, acute myocardial infarction, pulmonary embolism and deep vein thrombosis 1 2. Warfarin is an anticoagulant agent used for treatment and prophylaxis in thromboembolic events or clinical situations where there is a risk of thromboembolism 3.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous subscapular haematoma in a patient using warfarin therapy

et al. 2013

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Warfarin is widely used. Spontaneous bleeding is one of the complications of warfarin treatment. A 70-year-old man was admitted to the emergency room with right back pain. There was no history of trauma. He was using warfarin following a bypass graft. The patient's vital signs were stable. On physical examination, swelling at the level of the right scapula was detected. Laboratory findings showed that the international normalised ratio (INR) was ↑↑ (a very high reading) (1.47 1 month previously). There was no melena on rectal examination. A chest CT was performed to differentiate the swelling of the right scapula. Warfarin was stopped and vitamin K was administered. Fresh frozen plasma was initiated and the patient was hospitalised to the cardiovascular surgical service. The fact that use of warfarin in the elderly may increase the risk of spontaneous bleeding should be especially kept in mind.

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Bleeding Complications in Warfarin-Treated Patients Admitted to the Emergency Department

et al. 2019

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BackgroundIncreased use of warfarin for the treatment and prophylaxis of many diseases has increased the frequency of adverse events. Emergency departments (EDs) are the first places where early interventions for bleeding and other complaints related to warfarin use are performed. This study assessed the characteristics of patients receiving warfarin and the risk factors for bleeding complication among those admitted to the ED.MethodsPatients admitted to the ED for any reason other than trauma during a 1-year period were retrospectively reviewed. The study population consisted of 96 patients who had received warfarin and had an international normalized ratio (INR) ≥ 3. Patient demographics and medical history were recorded.ResultsThe mean age of the patients (female, 52.1%) was 64.9 ± 14.5 years. Fatigue was the most common presenting complaint (61%). At least one major and/or minor bleeding event had occurred in 32 (33.3%) of the patients. Patients with (n = 32) and without (n = 64) bleeding complications did not significantly differ with respect to age, sex, reason for warfarin initiation, duration of warfarin use, concomitant diseases, and concurrent medications. There were also no significant differences in the distribution of patient admissions in terms of season at presentation, INR level, and weekly warfarin dose.ConclusionsWhile the parameters evaluated in this study did not significantly differ among warfarin-treated patients, they may nonetheless pose a risk of bleeding. Further large-scale and long-term studies that take into account biological variation are required to precisely identify the risk factors for bleeding.

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The Analysis of Cases Admitted to Intensive Care Units from Emergency Department Due to Complications Related to Warfarin Treatment

Cited by 5 publications

References 17 publications

The Analysis of Patients Admitted to the Emergency Department Due to Complications Related to Warfarin Treatment

The Analysis of Patients Admitted to the Emergency Department Due to Complications Related to Warfarin Treatment

Spontaneous subscapular haematoma in a patient using warfarin therapy

Bleeding Complications in Warfarin-Treated Patients Admitted to the Emergency Department

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