Currently, and over the past decade, intensive research is being conducted in the field of organizational, preventive and therapeutic work with weather-sensitive and weather-dependent patients suffering from cardiovascular pathology. One of the most discussed issues in practical medicine is the application of climate conditions, with a fixed frequency and time of exposure. Conditions of influence of climatic factors, in some cases, can exceed the limits of the norm and, accordingly, have a pathological effect on the functional state of a person. Thus, we used data from statistically reliable results of 928 questionnaires processed and analyzed, reflecting the medical and social characteristics of patients with cardiovascular pathology. Direct results were evaluated by analyzing changes in the dynamics of indicators. According to a questionnaire survey, 62% of patients who have chronic diseases and seek medical help for diseases of the cardiovascular system believe that weather factors have a significant impact on their health. of the patients who do not have chronic diseases, 38% gave positive answers to the question about the weather sensitivity of their health. As part of the pilot project to create a system of long-term care for elderly and disabled citizens in the Voronezh region, patients are informed about the sources of obtaining specialized medical weather forecasts in the region; interaction between the parties is organized to conduct sanitary and educational work; medical examinations are organized and conducted; training sessions are organized for relatives of citizens who have lost the ability to self-service. Further organizational, preventive and therapeutic work with weather-sensitive and weather-dependent patients in the Voronezh region is characterized by an increase in the quality of medical care for patients with cardiovascular diseases.