The analysis of fatty acids and their derivatives in the liver of C57BL/6 mice with long-term caloric restrictions

Palma, Jorge; Maciejewska-Markiewicz, Dominika; Zgutka, Katarzyna; Piotrowska, Katarzyna; Skonieczna-Żydecka, Karolina; Stachowska, Ewa

doi:10.1016/j.prostaglandins.2023.106764

Cited by 2 publications

(1 citation statement)

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“…HFD also contains higher ratios of saturated fatty acids (SFA) to PUFAs, MUFAs to PUFAs, and oleic acid to linoleic acid than regular chow ( Supplemental Table 3 ). During decreased calorie intake such as during chronic CR, PUFAs, MUFAs, and SFAs decrease in fat depots and the ratio of oleic acid to linoleic acid decreases in liver 33,34 . Thus, we hypothesized that PUFAs, and/or the PUFA content relative to more saturated fatty acid species, regulate the rate at which mice entrain to seasonal light cycles.…”

Section: Resultsmentioning

confidence: 99%

Nutrient Abundance Signals the Changing of the Seasons by Phosphorylating PER2

Levine,

Reeh,

McMahon

et al. 2024

Preprint

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The circadian clock synchronizes metabolic and behavioral cycles with the rotation of the Earth by integrating environmental cues, such as light. Nutrient content also regulates the clock, though how and why this environmental signal affects the clock remains incompletely understood. Here, we elucidate a role for nutrient in regulating circadian alignment to seasonal photoperiods. High fat diet (HFD) promoted entrainment to a summer light cycle and inhibited entrainment to a winter light cycle by phosphorylating PER2 on serine 662. PER2-S662 phospho-mimetic mutant mice were incapable of entraining to a winter photoperiod, while PER2-S662 phospho-null mutant mice were incapable of entraining to a summer photoperiod, even in the presence of HFD. Multi-omic experimentation in conjunction with isocaloric hydrogenated-fat feeding, revealed a role for polyunsaturated fatty acids in nutrient-dependent seasonal entrainment. Altogether, we identify the mechanism whereby nutrient content shifts circadian rhythms to anticipate seasonal photoperiods in which that nutrient state predominates.

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Section: Resultsmentioning

confidence: 99%