The Analysis of Hormones and Enzymes Extracted from Endocrine Glands of the Neck Region in Deaths Due to Hanging

Şenol, Ender; Demirel, Birol; Akar, Taner; Gülbahar, Özlem; Bakar, Çoşkun; Bukan, Neslihan

doi:10.1097/paf.0b013e31815b4c80

Cited by 20 publications

(23 citation statements)

References 8 publications

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“…In previous studies [2][3][4][5][6], in cases without findings presumed to increase Tg concentration ( in heart blood were below the standard value for diagnosis (200 ng/mL). In these studies, forensic autopsies were performed within 24 h of death [2][3][4][5] or approximately 1-2 days after death [6].…”

Section: Introductionmentioning

confidence: 93%

“…Previous studies have reported that Tg concentrations in heart blood are high in cases of asphyxia caused by neck compression such as hanging, strangulation, and throttling, because a large quantity of Tg can leak from the thyroid gland by the damage of neck compression and enter the circulation [2][3][4][5]. Tamaki et al collected right heart blood (RHB) and left heart blood (LHB) separately and measured Tg concentrations in each blood sample [3].…”

Section: Introductionmentioning

confidence: 99%

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Appropriate blood sampling sites for measuring Tg concentrations for forensic diagnosis

et al. 2015

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Appropriate blood sampling sites for measuring Tg concentrations for forensic diagnosis

et al. 2015

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“…Therefore, in some cases of hanging, there are no fractures of the throat skeleton or even neck soft tissue injuries, and the question arose if these hangings were postmortem. Some authors suggested some new vital signs in cases of hanging such as high postmortem levels of thyroglobulin [13], histological finding of aggregates of pulmonary surfactant released in cases of mechanical asphyxia due to strong forced breathing [14], pneumomediastinum and neck soft tissue emphysema [15], and levels of stress hormones such as adrenaline and noradrenaline and their quotient, which are different compared to levels in sudden death or to the deaths with long agony [16]. Some authors suggest magnetic resonance imaging examination of the neck in addition to classical examination [17].…”

Section: Introductionmentioning

confidence: 98%

Simon’s bleedings: a possible mechanism of appearance and forensic importance—a prospective autopsy study

et al. 2009

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Simon's bleedings are stripe-like hemorrhages on the ventral surface of the intervertebral disks of the lumbar part of the spinal column. The aims of this study were to determine the appearance frequency of Simon's bleedings in cases of hanging and in other cases of asphyxiations and to determine if the age of the deceased was in correlation with the occurrence of Simon's bleedings. A prospective autopsic study included 147 cases of hanging, 39 other asphyxiation deaths, and 461 deaths other than asphyxiation (blunt trauma, natural deaths, etc.). Simon's bleedings were present in 62.8% cases of hanging and in 61.5% cases of other types of asphyxiations. Simon's bleedings are not specific for hanging (chi (2) = 0.022, p > 0.05). Simon's bleedings were less frequent in other cases. It was established that the older the person was, the possibility of Simon's bleedings to occur would be less (Spearman's correlation coefficient = -0.225, p < 0.001; Wald coefficient = 29.798, p < 0.001). In the cases of hanging, there is statistically significant difference in average age between the groups with and without Simon's bleedings (t = 2.875, p = 0.017). The older the person was, the lower the likelihood of Simon's bleedings to occur: if the person was more than 60 years old, there was 70% probability of not having Simon's bleedings, and if older than 70, this probability would rise to 88% (Wald coefficient = 7.609, p = 0.021). In older persons who died due to hanging, throat skeleton fractures accompanied by local hemorrhage could be considered as a vital sign. In younger persons, where throat skeleton fractures are less frequent, Simon's bleedings could be the vital sign of premortem hanging. Simon's bleedings, in cases of asphyxiation, most likely occur due to agonal convulsions and forced movements in lumbosacral part of spinal column. Additional factor for the appearance of Simon's bleedings in hanging is traction of body and especially this part of spinal column due to gravity.

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“…Müller et al [128] observed the highest Tg concentrations in the postmortem serum from heart blood in cases of incomplete suspension and manual strangulation. Similarly, Şenol et al [129] found increased heart blood Tg and T3 levels and normal heart blood thyroid stimulating hormone (TSH), T4, calcitonin, parathormone, and amylase levels in hangings.…”

Section: Adrenocorticotropic Hormonementioning

confidence: 99%

“…Thyroid stimulating hormone, thyreoglobulin, and thyroid hormones Several studies have been performed in order to detect increased thyreoglobulin (Tg), thyroxine (T4), and triiodothyronine (T3) levels in postmortem serum or blood in subject who died by hanging, ligature, or manual strangulation [128,129]. Müller et al [128] observed the highest Tg concentrations in the postmortem serum from heart blood in cases of incomplete suspension and manual strangulation.…”

Section: Adrenocorticotropic Hormonementioning

confidence: 99%

Postmortem chemistry update part II

Palmière

Mangin

2011

Int J Legal Med

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As a continuation of "Postmortem Chemistry Update Part I," Part II deals with molecules linked to liver and cardiac functions, alcohol intake and alcohol misuse, myocardial ischemia, inflammation, sepsis, anaphylaxis, and hormonal disturbances. A very important array of new material concerning these situations had appeared in the forensic literature over the last two decades. Some molecules, such as procalcitonin and C-reactive protein, are currently researched in cases of suspected sepsis and inflammation, whereas many other analytes are not integrated into routine casework. As in part I, a literature review concerning a large panel of molecules of forensic interest is presented, as well as the results of our own observations, where possible.

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The Analysis of Hormones and Enzymes Extracted from Endocrine Glands of the Neck Region in Deaths Due to Hanging

Cited by 20 publications

References 8 publications

Appropriate blood sampling sites for measuring Tg concentrations for forensic diagnosis

Appropriate blood sampling sites for measuring Tg concentrations for forensic diagnosis

Simon’s bleedings: a possible mechanism of appearance and forensic importance—a prospective autopsy study

Postmortem chemistry update part II

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