The Analysis of Korean Clinical Studies on the Effect of Pharmacopuncture for Whiplash Injury after Traffic Accidents

Yun, Jung Min; Hur, Na Yeon; Kim, Kyeong Han

doi:10.3831/kpi.2020.23.4.262

Cited by 1 publication

(1 citation statement)

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“…Jungsong-ouhyul pharmacopuncture (JOP), which consists of eight medicinal herbs such as Gardeniae Fructus, Olibanum, Myrrha, Corydalis Tuber, Persicae Semen, Salviae Miltiorrhizae Radix, Paeoniae Radix, and Sappan Lignum, is known to have effects such as such as promoting blood circulation, relieving pain, and reducing inflammation [ 5 , 6 ]. Cervi Parvum Cornu (CPC), a predominant nontoxic agent in TCM and TKM has also been reported to have the effect of replenishing Blood and Essence, tonifying Kidney Yang, and strengthening bones and muscles [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Single-Dose Intramuscular Toxicity Study of SU-Eohyeol Pharmacopuncture in Rats

Hwang

Jung

2022

J Pharmacopuncture

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Objectives This toxicological study was performed to assess for potential toxicity and to determine the approximate lethal dose of SU-Eohyeol pharmacopuncture (SUEP) following a single intramuscular injection of SUEP into male and female Sprague-Dawley (SD) rats. Methods The groups in our experiment consisted of an experimental group treated with SUEP at a dose of 1.0 mL/animal and a control group injected with a normal saline solution, and five male and female rats were placed in each group. Each animal was administered a single intramuscular injection. We monitored all rats for clinical signs and body weight changes for 14 days after administration. At the end of the observation period, the rats were euthanized and autopsied, and localized tolerance examinations were conducted at the site of administration of the test substance. Results There were no deaths in either sex in the SUEP-treated group. There was no significant difference between the SUEP-treated group and the control group in the clinical signs and weight changes among the rats. In addition, no significant SUEP-related changes were observed on autopsy findings or local tolerance examinations at the injection site by histopathological examination. Conclusion Our results suggest that the approximate lethal dose of a single intramuscular administration of SUEP in female and male rats under the conditions of this study is greater than 1.0 mL/animal. To determine the safety of the use of SUEP in Korean medical clinical practice, additional toxicity studies will be needed.

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Section: Introductionmentioning

confidence: 99%