The analysis of lacquer crack in the assessment of myopic choroidal neovascularization

Kim, Y M; Yoon, Jong-Su; Koh, Hyoung Jun

doi:10.1038/eye.2011.94

Cited by 38 publications

(18 citation statements)

References 21 publications

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“…3 High myopia can lead to myopic retinopathy, which presents with lacquer crack formation, choroidal neovascularization and chorioretinal atrophy. 4,5 These complications are highly associated with retinal vessel morphological alterations, such as narrower arterioles, which are visible on fundus photography. 4,5 Moreover, decreased choroidal blood flow has been associated with increasing axial length (AL), a possible indication of progressive myopia, 6 in both form deprivation and negative lens-induced myopic chick models.…”

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confidence: 99%

“…4,5 These complications are highly associated with retinal vessel morphological alterations, such as narrower arterioles, which are visible on fundus photography. 4,5 Moreover, decreased choroidal blood flow has been associated with increasing axial length (AL), a possible indication of progressive myopia, 6 in both form deprivation and negative lens-induced myopic chick models. 7,8 In highly myopic patients, reduced retinal vessel density 9 and blood flow 10 were evident in the retinal large vessels visible on fundus photo.…”

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confidence: 99%

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Retinal Microvascular Network and Microcirculation Assessments in High Myopia

Jiang

et al. 2017

American Journal of Ophthalmology

190

162

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Purpose To investigate the changes of the retinal microvascular network and microcirculation in high myopia. Design A cross-sectional, matched, comparative clinical study. Participants Twenty eyes of twenty subjects with non-pathological high myopia (28 ± 5 Years) with a refractive error of −6.31 ± 1.23 Diopters (mean ± standard deviation) and twenty eyes of twenty age- and gender-matched control subjects (30 ± 6 years) with a refractive error of −1.40 ± 1.00 Diopters were recruited. Methods Optical coherence tomography angiography (OCTA) was used to image the retinal microvascular network, which was later quantified by fractal analysis (box counting, Dbox, representing vessel density) in both superficial and deep vascular plexuses. The retinal function imager (RFI) was used to image the retinal microvessel blood flow velocity (BFV). The BFV and microvascular density in the myopia group were corrected for ocular magnification using Bennett’s formula. Results The density of both superficial and deep microvascular plexuses was significantly decreased in the myopia group in comparison to the controls (P < 0.05). The decrease of the microvessel density of the annular zone (0.6 – 2.5 mm), measured as Dbox, was 2.1% and 2.9% in superficial and deep vascular plexuses, respectively. The microvessel density reached a plateau from 0.5 mm to 1.25 mm from the fovea in both groups, but that in myopic group was about 3% lower than the control group. No significant differences were detected between the groups in retinal microvascular BFV in either arterioles or venules (P > 0.05). Microvascular densities in both superficial (r = −0.45, P = 0.047) and deep (r = −0.54, P = 0.01) vascular plexuses were negatively correlated with the axial lengths in the myopic eye. No correlations were observed between BFV and vessel density (P > 0.05). Conclusions Retinal microvascular decrease was observed in the high myopia subjects, whereas the retinal microvessel BFV remained unchanged. The retinal microvascular network alteration may be attributed to ocular elongation that occurs with the progression of myopia. The novel quantitative analyses of the retinal microvasculature may help to characterize the underlying pathophysiology of myopia and enable early detection and prevention of myopic retinopathy.

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confidence: 99%

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confidence: 99%

Retinal Microvascular Network and Microcirculation Assessments in High Myopia

Jiang

et al. 2017

American Journal of Ophthalmology

190

162

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“…In the late stage of the disease, the mCNV can regress into fibrovascular scars which stain the late phase of FA or atrophy can develop around the inactive CNV, which is seen as an increasing window defect on FA. Indocyanine green angiography (ICGA) is sometimes also helpful in imaging lesions blocked by hemorrhage and enable better visualization of lacquer cracks [33].…”

Section: Clinical Features Of Myopic Choroidal Neovascularization (Mcnv)mentioning

confidence: 99%

Management of Myopic Choroidal Neovascularization: Focus on Anti-VEGF Therapy

Teo

Lee

Cheung

2016

Drugs

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Myopic choroidal neovascularization (mCNV) is the second most common form of CNV after age-related macular degeneration (AMD). It is a sight-threatening complication of pathologic myopia (PM) and often affects patients in their working years causing significant impact on quality of life. Previous therapies such as photodynamic therapy with verteporfin have shown limited success. Due to the similarities in pathogenesis of mCNV and AMD CNV, anti-vascular endothelial growth factor therapy (anti-VEGF), which has so far been the mainstay of treatment for AMD CNV, has been shown to be effective in the treatment of mCNV and has become the first-line treatment of choice. This article aims to examine briefly the epidemiology and pathophysiology of mCNV, as well as review the evidence for efficacy, safety, and clinical use of anti-VEGF treatment for mCNV.

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“…Diseases such as AMD, polypoidal choroidal vasculopathy (PCV), CSC, and high myopia are thought to result from pathological changes in choroidal tissue (11)(12)(13)(14)(15). The incidence of AMD and PCV vary according to ethnicity.…”

Section: Discussionmentioning

confidence: 99%

Choroidal thickness in healthy Turkish subjects

Coşkun¹,

Okumuş²,

Gürler³

et al. 2014

Turk J Med Sci

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Flow injection cold vapor atomic absorption spectrometry (FI-CVAAS) was used for determination of cadmium in high salt matrices such as dialysis concentrates and textile leach solutions. The parameters such as acidity, concentration of reducing agent, reaction coil length, and carrier gas flow rate were investigated to obtain the best sensitivity. No significant background signal was observed even at high salt concentrations. Under the optimized conditions the limit of detection value (3s b m −1 , where sb is the standard deviation of the blank signals and m is the slope of the calibration graph) was found to be 0.05 ng mL −1 for an injection volume of 250 μ L and the precision in terms of relative standard deviation was 3.2% using 11 consecutive measurements of 0.5 ng mL −1 standard. The standard addition method was used for quantitation. The accuracy of the method was tested using ETAAS as a comparison method and a certified reference material (Waste Water EU-L-1). In both cases, the results were in good agreement at 95% confidence level. The concentrations of cadmium in textile product leach solutions were found to be below the limit value assigned by Oeko-Tex standards.

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The analysis of lacquer crack in the assessment of myopic choroidal neovascularization

Cited by 38 publications

References 21 publications

Retinal Microvascular Network and Microcirculation Assessments in High Myopia

Retinal Microvascular Network and Microcirculation Assessments in High Myopia

Management of Myopic Choroidal Neovascularization: Focus on Anti-VEGF Therapy

Choroidal thickness in healthy Turkish subjects

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