The analysis of lncRNA HOTAIR rs12826786 C&gt;T polymorphism and gastric cancer susceptibility in a Turkish population: lack of any association in a hospital-based case–control study

Ülger, Yakup; Dadaş, Erdoğan; Kaya, Berrin Yalınbaş; Sümbül, Ahmet Taner; Genç, Ahmet; Bayram, Süleyman

doi:10.1007/s11845-017-1596-x

Cited by 20 publications

(9 citation statements)

References 22 publications

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“…However, the results of these studies are inconsistent. For example, a previous study report that the T allele of rs12826786 increased the risk of developing adenocarcinoma of the gastric cardia in a Chinese population [28]; however, among the Turkish population, researchers found that the same variant (HOTAIR rs12826786 C>T polymorphism) was not associated with genetic susceptibility to gastric cancer [29]. In our study, we found that rs920778 was associated with the development of hepatocellular carcinoma.…”

Section: Discussioncontrasting

confidence: 46%

Association of Functional Genetic Variants of HOTAIR with Hepatocellular Carcinoma (HCC) Susceptibility in a Chinese Population

Tang

Liu

et al. 2017

Cell Physiol Biochem

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Background/Aims: The HOX transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), plays an important role in the pathogenesis and progression of multiple tumors. The aim of the present study was to evaluate whether common single nucleotide polymorphisms (SNPs) in HOTAIR are related to hepatocellular carcinoma (HCC) susceptibility in a Chinese population. Methods: We genotyped three SNPs of HOTAIR in a hepatocellular carcinoma (HCC) case-control study, including 482 cases and 520 control subjects. SNPs were genotyped using real-time polymerase chain reaction (RT-PCR). Associations between gene polymorphisms and HCC were evaluated using multiple logistic regression analysis. The allele-specific effects on HOTAIR expression in HCC were confirmed by real time quantitative PCR and luciferase activity assays. The influence of HOTAIR SNPs on the proliferation of HCC cells was evaluated using a CCK-8 assay. Results: Significant associations were observed between the HOTAIR rs920778 C>T polymorphism and HCC risk (TT versus CC: OR = 1.634, 95% CI =1.028-2.598, P = 0.046) and the allelic model (allele T versus allele C: OR =1.293, 95% CI = 1.060-1.577, P = 0.011). However, no statistically significant differences of rs4759314 and rs1899663 genotypes were observed between patients and controls (both P > 0.05). The increased risk for rs920778 TT genotype carriers was more evident in a sub-group of drinkers (OR = 3.103, 95% CI = 1.151-8.368, p=0.025) and in people positive for HBV infection (OR = 2.885, 95% CI = 1.086-7.663, p=0.034). RT-PCR and luciferase activity assay confirmed that the rs920778 TT genotype induced significantly higher HOTAIR levels than did the CC genotype (P < 0.05). CCK-8 assays and colony formation assays demonstrated that the rs920778 TT genotype had a higher proliferation rate of HCC cells than did the CC genotype (P < 0.05). Conclusion: These results suggest that SNP rs920778 of HOTAIR acts as a potential biomarker for predicting hepatocellular carcinoma, and further studies are warranted to confirm these findings.

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Section: Discussioncontrasting

confidence: 46%

Association of Functional Genetic Variants of HOTAIR with Hepatocellular Carcinoma (HCC) Susceptibility in a Chinese Population

Tang

Liu

et al. 2017

Cell Physiol Biochem

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“…15,16 Several studies investigated the impact of HOTAIR gene polymorphisms on the incidence risk of various cancers including BC, gastric cancer, prostate cancer, and ovarian cancer. [17][18][19][20][21][22][23][24][25] However, the data from these studies remain controversial and inconclusive. Furthermore, few studies have been conducted regarding the association of HOTAIR gene polymorphisms on BC risk.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms of HOTAIR gene are associated with the risk of breast cancer in a sample of southeast Iranian population

et al. 2017

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There is an increasing body of evidence which highlights the critical functions of long non-coding RNAs in the carcinogenicity mechanism of a variety of cancers. It has been reported that HOX transcript antisense intergenic RNA, a member of long non-coding RNA family, increases breast cancer risk. To date, no data regarding the association between HOX transcript antisense intergenic RNA polymorphisms and the risk of breast cancer development has been reported in Iran. Here, we examine the possible association between HOX transcript antisense intergenic RNA gene polymorphisms and breast cancer in a sample of southeast Iranian female population. The HOX transcript antisense intergenic RNA rs920778, rs12826786, rs4759314, and 1899663 gene polymorphisms were genotyped in 220 cases and 231 controls by polymerase chain reaction-restriction fragment length polymorphism. Our findings indicated that rs920778 polymorphism has significant positive association with breast cancer; rs12826786 and rs1899663 polymorphisms demonstrated significant negative association with breast cancer; and the rs4759314 variant was not associated with breast cancer risk. Haplotype analysis revealed that TGAC, CTAT, and TTAT haplotypes significantly decreased the risk of breast cancer compared with rs920778T/rs1899663G/rs4759314A/rs12826786T haplotype. In conclusion, we investigated only four variants of HOX transcript antisense intergenic RNA gene, and the findings suggest that HOX transcript antisense intergenic RNA rs920778, rs12826786, and rs1899663 polymorphisms may be associated with breast cancer risk in a sample of southeast Iranian population. Further replication studies with other polymorphisms of HOX transcript antisense intergenic RNA gene involving a greater sample size and different ethnicities are necessary to verify our findings.

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“…The functional role of long non-coding RNA (lncRNAs) in the biological activity of malignant tumor has been widely investigated [3] , [4] . By regulating the expression of target gene through different mechanisms, lncRNAs have been reported to be associated the growth and metastasis of a variety of cancer [5] , [6] , [7] . Aberrant upregulation of oncogenic lncRNA TUG1 was observed in B-cell malignancies, bladder cancer, hepatocellular carcinoma and OS [8] .…”

Section: Introductionmentioning

confidence: 99%

A promoter variant of lncRNA GAS5 is functionally associated with the development of osteosarcoma

Xia

Bai

et al. 2018

Journal of Bone Oncology

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The analysis of lncRNA HOTAIR rs12826786 C>T polymorphism and gastric cancer susceptibility in a Turkish population: lack of any association in a hospital-based case–control study

Cited by 20 publications

References 22 publications

Association of Functional Genetic Variants of HOTAIR with Hepatocellular Carcinoma (HCC) Susceptibility in a Chinese Population

Association of Functional Genetic Variants of HOTAIR with Hepatocellular Carcinoma (HCC) Susceptibility in a Chinese Population

Genetic polymorphisms of HOTAIR gene are associated with the risk of breast cancer in a sample of southeast Iranian population

A promoter variant of lncRNA GAS5 is functionally associated with the development of osteosarcoma

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