The Analysis of Serum Vitamin D (25[OH]D) Level in Psoriasis Patients Comparing with Control Subjects

Fernandes, Ade; Listiawan, M. Yulianto; Ervianti, Evy; Setyaningrum, Trisniartami

doi:10.20473/bikk.v32.2.2020.111-118

Cited by 3 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, we identified that low levels of circulating 25(OH)D3 and C3-epi-25(OH)D3 increase the risk of psoriasis, highlighting their potential causal effects for the first time. 14 Vitamin D receptors are widely distributed in immune cells, suggesting its role in modulating immune responses. In psoriasis, abnormal vitamin D metabolism may activate T cells and regulate cytokine secretion.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness, Outcome, and Safety of Vitamin D Supplementation in Patients With Psoriasis: A Comprehensive Systematic Review

Yulianto,

Aristika Gunawan

2024

JARMHS

View full text Add to dashboard Cite

Background: Insights into psoriasis as a systemic ailment have spurred the investigation of novel therapies due to dissatisfaction with current treatments and significant quality of life impairment. Vitamin D3 deficiency is implicated in psoriasis pathophysiology, with studies highlighting its impact on keratinocyte regulation and autoimmune disease resistance. This review critically evaluates evidence on high-dose oral vitamin D3 supplementation for psoriasis management, aiming to assess its effectiveness, treatment outcomes, and safety profile to inform clinician. Methods: This systematic review focused on full-text English literature published between 2017 and 2024 using the PRISMA 2020 guidelines. Editorials and review pieces published in the same journal as the submission without a DOI were not accepted. The literature was compiled using PubMed, ScienceDirect, and SagePub, among other online venues. Result: Our research team initially collected numerous publications from credible sources such as Science Direct, PubMed, and JAMA Dermatology. Employing a meticulous three-tier screening approach, we identified only five papers that were directly pertinent to our ongoing systematic assessment. Subsequently, we conducted a comprehensive examination of the entire text and further selected articles; case control study, double-blind, randomized, placebo-controlled study, randomized controlled trial, a bidirectional two-sample mendelian randomization analysis, and observational cross-sectional study. Conclusion: In conclusion, maintaining serum vitamin D levels above 30 ng/ml may benefit severe psoriasis, while oral vitamin D2 supplementation showed promise in mild cases. Larger trials are needed for severe psoriasis, and future research should explore higher doses. Additionally, a study found no support for monthly vitamin D3 supplementation in older mild psoriasis patients. We confirmed the causal link between vitamin D levels and psoriasis, identified associations with increased risk, and explored effects on atopic dermatitis. While no significant difference was found in serum vitamin D levels between psoriasis patients and controls, lower levels in psoriasis suggest various influences.

show abstract

Section: Discussionmentioning

confidence: 99%

Effectiveness, Outcome, and Safety of Vitamin D Supplementation in Patients With Psoriasis: A Comprehensive Systematic Review

Yulianto,

Aristika Gunawan

2024

JARMHS

View full text Add to dashboard Cite

show abstract

“…Pasien dengan psoriasis berisiko mengalami defisiensi vitamin. Studi (Fernandes et al, 2020) yang dilakukan di Surabaya membuktikan bahwa sebanyak 81,25% pasien psoriasis vulgaris mengalami defisiensi vitamin D dibandingkan dengan kontrol (68,75%). Studi meta-analysis oleh (Lei et al, 2019) menunjukkan bahwa pada pasien psoriasis memiliki kadar seng dan copper (Cu) yang rendah dibandingkan orang sehat.…”

Section: Pendahuluanunclassified

Terapi Medik Gizi pada Psoriasis Pustulosa Generalisata: Laporan Kasus

Dewi,

Sonia,

Andayani

2024

jsi

View full text Add to dashboard Cite

Psoriasis Pustulosa Generalisata (PPG) merupakan jenis psoriasis yang jarang terjadi. PPG merupakan penyakit autoinflamasi yang terjadi di kulit dan sistemik. Manifestasi kulit ditandai dengan inflamasi di epidermis, pustul multipel dan hiperkeratosis, sedangkan salah satu manifestasi sistemik berupa sepsis. Pemberian nutrisi berperan dalam pencegahan malnutrisi, mendukung proses penyembuhan dan mengatasi inflamasi. Laki-laki berusia 32 tahun masuk rumah sakit dengan keluhan utama bercak kemerahan dengan bintik-bintik bernanah yang semakin meluas sejak 3 hari SMRS. Keluhan lain berupa demam dan bengkak di tungkai bawah. Status gizi pasien adalah berat badan normal. Terdapat anemia, leukositosis, hipoalbuminemia dan peningkatan kadar C-Reactive Protein (CRP). Pemeriksaan histopatologis tidak dilakukan. Pasien didiagnosis dengan PPG (total body surface area 75%) dan sepsis et causa Skin and Soft Tissue Infection (SSTI). Pasien mendapatkan terapi antibiotik sistemik per oral, kortikosteroid topikal, dan kompres NaCl 0,9%. Selama perawatan, pasien mendapat asupan nutrisi secara adekuat melalui oral berupa makanan padat dan makanan cair tinggi protein. Pasien mendapatkan transfusi albumin 20% 100 mL sebanyak 1 kali. Mikronutrien diberikan berupa vitamin A, vitamin B kompleks, vitamin C, vitamin D, asam folat dan zinc per oral. Pasien dirawat di rumah sakit selama 16 hari. Pada akhir pemantauan, status gizi normal dapat dipertahankan, terdapat penurunan luas lesi kulit menjadi sebesar 30%, kadar albumin meningkat dari 2,3 menjadi 2,8 g/dL, dan penurunan kadar CRP. Pemberian makro- dan mikronutrien yang adekuat pada PPG dapat mempertahankan status gizi yang baik, menunjang proses penyembuhan lesi kulit, dan perbaikan kadar inflamasi.

show abstract

“…Moreover these studies were limited by small sample size and clinical and methodological heterogenecity among the study groups. 4 Further, among case-control studies published between 2019 and 2021, few of them showed significant association between 25(OH) D levels and psoriasis, [5][6][7][8][9] while other remaining studies did not show a significant association between level of 25(OH) D with psoriasis. [10][11][12][13][14] Hence in conclusion from the literature review of clinical studies available to date, the association between psoriasis and vitamin D is still controversial.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Vitamin D Level in Patients with Psoriasis and Its Correlation with Disease Severity: A Case–Control Study

Pokharel¹,

Agrawal²,

Pandey³

et al. 2022

PTT

View full text Add to dashboard Cite

Background Chronic plaque psoriasis is a chronic inflammatory skin disorder. Vitamin D has been shown to have effects on keratinocyte differentiation as well as immune regulation in the skin. Objective The main objective of this study was to assess the 25hydroxyvitamin D [25 (OH) D] level in patients with psoriasis in comparison with healthy control subjects. Materials and Methods This case–control study included 180 persons (120 cases and 60 age- and sex-matched control subjects) from outpatient department of BPKIHS, a tertiary care hospital in eastern Nepal. Severity of psoriatic skin lesions was assessed using psoriasis area severity index (PASI) scoring. Serum vitamin D level was assessed by chemiluminescent immunoassay. Results The mean serum 25(OH) D levels in psoriatic patients and controls were 19.57 ± 6.85 ng/mL and 23.63 ± 6.40 ng/mL, respectively. The difference was statistically significant even after adjusting for confounding factors in a multivariate analysis (aOR 2.929, 95% CI 1.376–6.230). Low serum 25(OH) D levels were negatively associated with the severity of disease (r= −0.628, P= 0.01). Conclusion Serum 25(OH) D levels are significantly lower in psoriatic patients than in healthy control subjects. Deficiency of serum 25(OH) D was associated with severity of disease with an inverse relationship with PASI score.

show abstract

The Analysis of Serum Vitamin D (25[OH]D) Level in Psoriasis Patients Comparing with Control Subjects

Cited by 3 publications

References 25 publications

Effectiveness, Outcome, and Safety of Vitamin D Supplementation in Patients With Psoriasis: A Comprehensive Systematic Review

Effectiveness, Outcome, and Safety of Vitamin D Supplementation in Patients With Psoriasis: A Comprehensive Systematic Review

Terapi Medik Gizi pada Psoriasis Pustulosa Generalisata: Laporan Kasus

Assessment of Vitamin D Level in Patients with Psoriasis and Its Correlation with Disease Severity: A Case–Control Study

Contact Info

Product

Resources

About