The Analysis of the Chemical Drugs among Structural Isomer

Abstract

Drugs that have a pharmacological eŠect similar to legal drugs such as narcotics and stimulants are available in the market and widely used. 5-methoxy-N,N-di-iso-propyl-tryptamine (5MeO-DIPT) and a-methyl-tryptamine (AMT) were categorized as narcotics and were speciˆed as legal drugs in April 2005, and also 2,5-dimethoxy-4-n-propylthiophenethylamine (4C-T-7) and N-methyl-a-ethy-3,4-methylenedioxy-phenethylamine (MBDB) were categorized as narcotics and were speciˆed as legal drugs in April 2006, in Japan. We are analyzing these chemical drugs by investigating the market research. It is recognized that during the analysis of chemical drugs, drugs that resemble a structural isomer of a target substance, such as 5MeO-DIPT and 5-methoxy-N,N-di-n-propyl-tryptamine (5MeO-DPT) or 4C-T-7 and 2,5-dimethoxy-4-iso-propylthiophenethylamine (4C-T-4), should be distinguished. The results of TLC, IR, GC-MS and HPLC analyses were compared. 5MeO-DIPT and 5MeO-DPT could be distinguished by TLC and HPLC analyses, but not by IR and GC-MS analysis. The drugs 4-hydroxy-N-methyl-N-iso-propyl-tryptamine (4HO-MIPT) and 4-hydroxy-N,N-di-ethyl-tryptamine (4HO-DET) or could not be distinguished. Moreover, the isomers of 4-hydroxy-N-methyl-Nn-propyl-tryptamine (4HO-MPT) was not found to be present. Thus, we have demonstrated that the chemical drug could be distinguished from each other, and we have also shown that NMR data is essential for the analysis.Key words-abuse drug; structural isomerism; 5-methoxy-N,N-di-iso-propyl-tryptamine; 5-methoxy-N,N-di-npropyl-tryptamine; chemical drug

UPLC/ESI‐MS/MS‐based determination of metabolism of several new illicit drugs, ADB‐FUBINACA, AB‐FUBINACA, AB‐PINACA, QUPIC, 5F‐QUPIC and α‐PVT, by human liver microsome

“…The use of illicit drugs is also a gateway to narcotic drug abuse. In Japan, the Pharmaceutical Affairs Law was revised, and the regulation was tightened by introducing a system of controlled substances, designated as Shitei-Yakubutsu, in April 2007 (31 compounds and one plant; Uchiyama et al, 2010;Doi et al, 2006). More than 100 compounds possessing various structures such as phenethylamines, tryptamines, cathinones, piperadines and cannabinoids are currently listed as Shitei-Yakubutsu (Uchiyama et al, 2012a(Uchiyama et al, , 2012b.…”

PeakAL: Protons I Have Known and Loved - Fifty Shades of Grey-Market Spectra. Supplementary Data

“…[66] 1 Formerly thioether. H NMR spectra have been reported for 2C-T-2 in CDCl3, [67] in CD3OD, [43] and in D2O [48,68] ; for 2C-T-4 in CDCl3, [69] and in D2O [48] ; for 2C-T-7 in CDCl3, [69] in CD3OD, [43] and in D2O. [48,70] We have not found 1 H NMR spectra reported for 2C-T.…”

Rapid enantiomeric separation and simultaneous determination of phenethylamines by ultra high performance liquid chromatography with fluorescence and mass spectrometric detection: application to the analysis of illicit drugs distributed in the Japanese market and biological samples

“…The use of illicit drugs is also the gateway to narcotic and psychostimulant drugs abuse. In Japan, the Pharmaceutical Affairs Law was revised, and the regulation was tightened by introducing a system of controlled substances, designated as Shitei‐Yakubutsu, in April 2007 (31 compounds and 1 plant) . Under this Act, compounds that have potential harmful health effects are designated Shitei‐Yakubutsu, and rapid response to such compounds is facilitated.…”

“…In Japan, the Pharmaceutical Affairs Law was revised, and the regulation was tightened by introducing a system of controlled substances, designated as Shitei-Yakubutsu, in April 2007 (31 compounds and 1 plant). [1,2] Under this Act, compounds that have potential harmful health effects are designated Shitei-Yakubutsu, and rapid response to such compounds is facilitated. This system temporarily decreased the distribution of designated substances in Japan.…”