Smoke is the main threat of death in fires. For this reason, it becomes extremely important to understand the dispersion of this pollutant and to verify the influence of different control systems on its spread through buildings, in order to avoid or minimize its effects on living beings. Thus, this work aims to perform thermo-fluid dynamic study of smoke dispersion in a closed environment. All numerical analysis was performed using the Fire Dynamics Simulator (FDS) software. Different simulations were carried out to evaluate the influence of the exhaust system (natural or mechanical), the heat release rate (HRR), ventilation and the smoke curtain in the pollutant dispersion. Results of the smoke layer interface height, temperature profile, average exhaust volumetric flow rate, pressure and velocity distribution are presented and discussed. The results indicate that an increase in the natural exhaust area increases the smoke layer interface height, only for the well-ventilated compartment (open windows); an increase in the HRR accelerates the downward vertical displacement of the smoke layer and that the 3 m smoke curtain is efficient in exhausting smoke, only in the case of poorly ventilated compartments (i.e., with closed windows).